Volume 16, Issue 8 (August 2018)                   IJRM 2018, 16(8): 497-500 | Back to browse issues page

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Gonzalez-Añover P, Torres-Rovira L, García-Contreras C, Vazquez-Gomez M, Pesantez J L, Sanz-Fernandez M V, et al . Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study. IJRM 2018; 16 (8) :497-500
URL: http://ijrm.ir/article-1-1176-en.html
Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study
Pedro Gonzalez-Añover1 , Laura Torres-Rovira2 , Consolacion García-Contreras2 , Marta Vazquez-Gomez1 , Jose Luis Pesantez3 , Maria Victoria Sanz-Fernandez2 , Susana Astiz2 , Antonio Gonzalez-Bulnes * 4
1- Faculty of Veterinary Sciences, UCM, Madrid, Spain
2- Comparative Physiology Group, SGIT-INIA, Madrid, Spain
3- School of Veterinary Medicine and Zootechnics, Faculty of Agricultural Sciences, University of Cuenca, Cuenca, Ecuador
4- Comparative Physiology Group, SGIT-INIA, Madrid, Spain , bulnes@inia.es
Abstract:   (2565 Views)
Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction.
Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses.
Materials and Methods: The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35). The antioxidant status of the plasma samples was determined by photoinduced chemiluminescence whilst systemic oxidative stress was assessed determining plasma hydrogen peroxide concentration by enzimoimmunoassay.
Results: Plasma total antioxidant capacity was significantly lower in leptin-resistant fetuses (p=0.003), whilst systemic oxidative stress was increased (p=0.02).
Conclusion: Our results indicate key differences in the antioxidant status in pregnancies affected by leptin resistance
Keywords: Animal models, Fetus, Leptin, Oxidative stress, Pregnancy
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Type of Study: Original Article |
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