International Journal of
Reproductive Biomedicine
Sat, Apr 20, 2024
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Volume 6, Issue 4 (7-2008)
IJRM 2008, 6(4): 133-0 |
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Niknafs B, Afshari F, Dezfulian A. Morphological and morphometrical changes of endometrim after application of estrogen and progesterone during luteal phase in the superovulated mice. IJRM 2008; 6 (4) :133-0
URL: http://ijrm.ir/article-1-121-en.html
URL: http://ijrm.ir/article-1-121-en.html
1- Department of Anatomy, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran , niknafsbeh@yahoo.com
2- Department of Histology, Medical Faculty, Islamic Azad University, Tabriz Branch, Iran
3- Department of Histology, Medical Faculty, Ahvaz University of Medical Sciences, Ahvaz, Iran
2- Department of Histology, Medical Faculty, Islamic Azad University, Tabriz Branch, Iran
3- Department of Histology, Medical Faculty, Ahvaz University of Medical Sciences, Ahvaz, Iran
Abstract: (2365 Views)
Background: The application of luteal phase supplementation hormones to increase the implantation rate is on debate among researchers.
Objective: In this study, the morphological and morphometrical assessment of superovulated mice endometrium were investigated at window implantation period superovulated mice.
Materials and Methods: Female mice were superovualated then were mated with vasectomized mice; the mice were divided in experimental and control groups. Experimental group included five groups which in them pseudopregnant mice were given a four consecutive daily injection of 1-progesterone (P), 2-estrogen (E), 3-estrogen + progesterone, 4-antiprogesterone+estrogen and 5-sham group. The uterine of all groups were collected after 4.5 day of pseudopregnancy and were prepared for histological and morphometrical studies.
Results: Morphological studies of endometrial tissue showed that the luminal epithelium in group P appeared cuboidal shape. Endometrial folding was very high in group E+P. The luminal epithelium in groups E, E+P and RU 486 + E were seen in different morphology in comparison to control group. Morphometrical evaluation also showed height of luminal epithelium in group E (32.7±0.67) and E+P (33.6±1.3) were higher than those were seen in control (22.5±1.5) and group P (15.3±1.2).
Conclusion: Progesterone caused the lowest endometrial development compare to other groups. It is concluded that the adding of E to P may improve endometrial condition to implant at luteal phase.
Objective: In this study, the morphological and morphometrical assessment of superovulated mice endometrium were investigated at window implantation period superovulated mice.
Materials and Methods: Female mice were superovualated then were mated with vasectomized mice; the mice were divided in experimental and control groups. Experimental group included five groups which in them pseudopregnant mice were given a four consecutive daily injection of 1-progesterone (P), 2-estrogen (E), 3-estrogen + progesterone, 4-antiprogesterone+estrogen and 5-sham group. The uterine of all groups were collected after 4.5 day of pseudopregnancy and were prepared for histological and morphometrical studies.
Results: Morphological studies of endometrial tissue showed that the luminal epithelium in group P appeared cuboidal shape. Endometrial folding was very high in group E+P. The luminal epithelium in groups E, E+P and RU 486 + E were seen in different morphology in comparison to control group. Morphometrical evaluation also showed height of luminal epithelium in group E (32.7±0.67) and E+P (33.6±1.3) were higher than those were seen in control (22.5±1.5) and group P (15.3±1.2).
Conclusion: Progesterone caused the lowest endometrial development compare to other groups. It is concluded that the adding of E to P may improve endometrial condition to implant at luteal phase.
Type of Study: Original Article |
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