Volume 16, Issue 11 (November 2018)                   IJRM 2018, 16(11): 679-682 | Back to browse issues page

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Firmansyah A, Tadjuddin Chalid M, Budiati Farid R, Abdullah N. The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance. IJRM 2018; 16 (11) :679-682
URL: http://ijrm.ir/article-1-1295-en.html
The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance
Arini Firmansyah1 , Maisuri Tadjuddin Chalid * 2, Retno Budiati Farid1 , Nusratuddin Abdullah1
1- Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia.
2- Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia. , maisurichalid@gmail.com
Abstract:   (2293 Views)
Background: The underlying etiology of polycystic ovarian syndrome (PCOS) is unknown and assumed to have a strong correlation with insulin resistance. Homeostasis Model Assessment of insulin resistance (HOMA-IR) is a good tool to assess insulin resistance. Low levels of serum Insulin-like Growth Factor-Binding Protein-1 (IGFBP-1) in PCOS women led to the hypothesis that hyperinsulinemia in PCOS inhibits the production of IGFBP-1, which in turn stimulates excessive androgen production.
Objective: The study is aimed to analyze the correlation between the levels of IGFBP-1 and HOMA-IR on insulin resistance in PCOS.
Materials and Methods: A cross-sectional study among 105 PCOS women, including 60 women with insulin resistance were recruited. The mean of IGFBP-1 and HOMA-IR were 6.507±4.7821 μg/l and 3.633±1.666 respectively.
Results: Low levels of IGFBP-1 were detected in all insulin resistance women. There was a correlation between HOMA-IR and overweight (p=0.045), while IGFBP-1 showed no correlation with overweight (p=0.106). In addition, no correlation between IGFBP-1 with HOMA-IR as a marker of insulin resistance was detected.
Conclusion: Despite the decrease in IGFBP-1, it seems that there is no correlation between IGFBP-1 with HOMA-IR as a marker of insulin resistance.
Keywords: Insulin-like growth factor binding protein 1, Insulin resistance, Polycystic ovarian syndrome.
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Type of Study: Original Article |
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