International Journal of
Reproductive Biomedicine
Sat, Apr 20, 2024
[Archive]
Volume 18, Issue 12 (December 2020)
IJRM 2020, 18(12): 1005-1018 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hassanipour S, Bagheri Faradonbeh S, Momeni K, Heidarifard Z, Khosousi M, Khosousi L, et al . A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes. IJRM 2020; 18 (12) :1005-1018
URL: http://ijrm.ir/article-1-1891-en.html
URL: http://ijrm.ir/article-1-1891-en.html
Soheil Hassanipour1 
, Saeed Bagheri Faradonbeh2 , Khalil Momeni3 , Zahra Heidarifard4 , Mohammad-Javad Khosousi1 , Leila Khosousi5 , Hosein Ameri6 , Morteza Arab-Zozani * 7
, Saeed Bagheri Faradonbeh2 , Khalil Momeni3 , Zahra Heidarifard4 , Mohammad-Javad Khosousi1 , Leila Khosousi5 , Hosein Ameri6 , Morteza Arab-Zozani * 7
1- Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
2- Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.
4- Tehran University of Medical Sciences, Tehran, Iran.
5- Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
6- Health Policy and Management Research Center, Department of Health Services Management, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
7- Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. , arab.hta@gmail.com
2- Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.
4- Tehran University of Medical Sciences, Tehran, Iran.
5- Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
6- Health Policy and Management Research Center, Department of Health Services Management, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
7- Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. , arab.hta@gmail.com
Abstract: (1707 Views)
Background: Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 appeared in December 2019 in Wuhan, China.
Objective: To investigate the clinical manifestations including signs and symptoms, laboratory results, and perinatal outcomes in pregnant women with COVID-19.
Materials and Methods: Scholarly databases such as PubMed via LitCovid hub, Embase, Scopus, Web of sciences, and Google scholar were searched on April 7, 2020. Meta-analysis was performed via comprehensive meta-analysis software using the Mantel-Haenszel method. The event rate with 95% CI was calculated for each variable.
Results: Ten studies were selected. The pooled prevalence for fever, post-partum fever, cough, myalgia, fatigue, dyspnea, sore throat, and diarrhea were 66.8%, 37.1%, 35%, 24.6 %, 14.9%, 14.6%, 11.5%, and 7.6%, respectively. Laboratory test results were 49.8% for lymphopenia, 47.7% for leukocytosis, 83.7% for elevated neutrophil ratio, 57% for elevated C-reactive protein, and 71.4% for decreased lymphocyte ratio. The rate of cesarean section for delivery in all cases was 84%. Of the newborns of the corona-positive mothers, only one had a positive test result. Also, there was only one death due to a decreased lymphocyte ratio.
Conclusion: Fever was the most common sign and symptom in pregnant women with COVID-19. Among the laboratory tests, the highest amount was related to elevated neutrophil ratio. It seems that due to the differences between pregnant women and the general population, special measures should be considered to treat these patients.
Objective: To investigate the clinical manifestations including signs and symptoms, laboratory results, and perinatal outcomes in pregnant women with COVID-19.
Materials and Methods: Scholarly databases such as PubMed via LitCovid hub, Embase, Scopus, Web of sciences, and Google scholar were searched on April 7, 2020. Meta-analysis was performed via comprehensive meta-analysis software using the Mantel-Haenszel method. The event rate with 95% CI was calculated for each variable.
Results: Ten studies were selected. The pooled prevalence for fever, post-partum fever, cough, myalgia, fatigue, dyspnea, sore throat, and diarrhea were 66.8%, 37.1%, 35%, 24.6 %, 14.9%, 14.6%, 11.5%, and 7.6%, respectively. Laboratory test results were 49.8% for lymphopenia, 47.7% for leukocytosis, 83.7% for elevated neutrophil ratio, 57% for elevated C-reactive protein, and 71.4% for decreased lymphocyte ratio. The rate of cesarean section for delivery in all cases was 84%. Of the newborns of the corona-positive mothers, only one had a positive test result. Also, there was only one death due to a decreased lymphocyte ratio.
Conclusion: Fever was the most common sign and symptom in pregnant women with COVID-19. Among the laboratory tests, the highest amount was related to elevated neutrophil ratio. It seems that due to the differences between pregnant women and the general population, special measures should be considered to treat these patients.
Type of Study: Review Article |
Subject:
Reproductive Epidemiology
References
1. 1. Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ 2020; 368: 1-7.
2. 2. Arab-Zozani M, Hassanipour S. Features and limitations of LitCovid hub for quick access to literature about COVID-19. Balkan Med J 2020; 37: 231-232.
3. 3. Petrosillo N, Viceconte G, Ergonul O, Ippolito G, Petersen E. COVID-19, SARS and MERS: are they closely related? Clinical Microbiology and Infection 2020; 26: 729-734.
4. 4. Meo SA, Alhowikan AM, Al-Khlaiwi T, Meo IM, Halepoto DM, Iqbal M, et al. Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV. Eur Rev Med Pharmacol Sci 2020; 24: 2012-2019.
5. 5. Fang Zh, Zhang Y, Hang Ch, Ai J, Li Sh, Zhang W. Comparisons of viral shedding time of SARS-CoV-2 of different samples in ICU and non-ICU patients. J Infect 2020; 81: 147-178.
6. 6. Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients. Can J Anaesth 2020; 67: 568-576.
7. 7. Chan JFW, Yuan Sh, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet 2020; 395: 514-523.
8. 8. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis 2020; 34: 101623.
9. 9. Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections. Viruses 2020; 12: 194-209.
10. 10. Favre G, Pomar L, Musso D, Baud D. 2019-nCoV epidemic: What about pregnancies? Lancet 2020; 395: e40.
11. 11. Wong ShF, Chow KM, Leung TN, Ng WF, Ng TK, Shek ChC, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol 2004; 191: 292-297.
12. 12. Mertz D, Geraci J, Winkup J, Gessner BD, Ortiz JR, Loeb M. Pregnancy as a risk factor for severe outcomes from influenza virus infection: A systematic review and meta-analysis of observational studies. Vaccine 2017; 35: 521-528.
13. 13. Chen YH, Keller J, Wang IT, Lin ChCh, Lin HCh. Pneumonia and pregnancy outcomes: a nationwide population-based study. Am J Obstet Gynecol 2012; 207: 288. e1-e7.
14. 14. Chen R, Chen J, Meng QT. Chest computed tomography images of early coronavirus disease (COVID-19). Can J Anaesth 2020; 67: 754-755.
15. 15. Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 2011; 1221: 80-87.
16. 16. Gottfredsson M. The spanish flu in iceland 1918. Lessons in medicine and history. Laeknabladid 2008; 94: 737-745.
17. 17. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow DL, Biggerstaff MS, et al. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet 2009; 374: 451-458.
18. 18. Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010; 8: 336-341.
19. 19. Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, et al. Methodological quality of case series studies: An introduction to the JBI critical appraisal tool. JBI Evidence Synthesis 2020; 18: 2127-2133.
20. 20. Joanna Briggs Institute. Critical appraisal checklist for case reports. Available at: https://joannabriggs.org/critical-appraisal-tools.
21. 21. Arab-zozani M, Mostafazadeh N, Arab-zozani Z, Ghoddoosi-Nejad D, Hassanipour S, Soares JJF. The prevalence of elder abuse and neglect in Iran: A systematic review and meta-analysis. J Elder Abuse Negl 2018; 30: 408-423.
22. 22. Chen H, Guo J, Wang Ch, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet 2020; 395: 809-815.
23. 23. Gidlöf S, Savchenko J, Brune T, Josefsson H. COVID-19 in pregnancy with comorbidities: More liberal testing strategy is needed. Acta Obstet Gynecol Scand 2020; 99: 948-949.
24. 24. Li N, Han L, Peng M, Lv Y, Ouyang Y, Liu K, et al. [Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: A case-control study]. Clin Infect Dis 2020. (in Press)
25. 25. Khan S, Peng L, Siddique R, Nabi Gh, Nawsherwan U, Xue M, et al. Impact of COVID-19 infection on pregnancy outcomes and the risk of maternal-to-neonatal intrapartum transmission of COVID-19 during natural birth. Infect Control Hosp Epidemiol 2020; 41: 748-750.
26. 26. Liu H, Wang LL, Zhao SJ, Kwak-Kim J, Mor G, Liao AH. Why are pregnant women susceptible to COVID-19? An immunological viewpoint. J Reprod Immunol 2020; 139: 103122.
27. 27. Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A preliminary analysis. Am J Roentgenol 2020; 215: 127-132.
28. 28. Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect 2020; 80: e7-e13.
29. 29. Zhang B, Liu Sh, Tan T, Huang W, Dong Y, Chen L, et al. Treatment with convalescent plasma for critically Ill patients with severe acute respiratory syndrome coronavirus 2 infection. Chest 2020; 158: e9-e13.
30. 30. Yu N, Li W, Kang Q, Xiong Zh, Wang Sh, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. Lancet Infect Dis 2020; 20: 559-564.
31. 31. Zhu H, Wang L, Fang Ch, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr 2020; 9: 51-60.
32. 32. Guan WJ, Ni ZhY, Hu Y, Liang WH, Ou CHQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708-1720.
33. 33. Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy 2020; 75: 1730-1741.
34. 34. Wang D, Hu B, Hu Ch, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323: 1061-1069.
35. 35. De Brouwere V, Dubourg D, Richard F, Van Lerberghe W. Need for caesarean sections in west Africa. Lancet 2002; 359: 974-975.
36. 36. Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J 2019; 16: 69-90.
37. 37. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579: 270-273.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
