Volume 9, Issue 4 (7-2011)                   IJRM 2011, 9(4): 315-318 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rashidi B, Nasiri R, Rahmanpour H, Shahrokh Tehraninejad E, Deldar M. Luteal phase estradiol versus luteal phase GnRH antagonist administration: their effects on antral follicular size coordination and basal hormonal levels. IJRM 2011; 9 (4) :315-318
URL: http://ijrm.ir/article-1-241-en.html
Luteal phase estradiol versus luteal phase GnRH antagonist administration: their effects on antral follicular size coordination and basal hormonal levels
Batool Rashidi1 , Roya Nasiri2 , Haleh Rahmanpour * 3, Ensieh Shahrokh Tehraninejad1 , Maryam Deldar1
1- Valie-Asr Reproductive Health Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, Aria Hospital, Faculty of Medicine, Islamic Azad University of Medical Sciences, Mashhad Branch, Mashhad, Iran
3- Department of Obstetrics and Gynecology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran , haleh509@gmail.com
Abstract:   (2552 Views)
Background: The differential efficacy between long GnRH agonist with antagonist can partly be due to the preexisting differences in the early antral follicles before ovarian stimulation.
Objective: To compare the effect of pretreatment by estradiol with GnRH antagonist on antral follicular size coordination and basal hormone levels in GNRH antagonist protocol.
Materials and Methods: On cycle day 3 (control/day 3), women underwent measurements of early antral follicles by ultrasound and serum FSH and ovarian hormones then were randomized to receive oral estradiol 4mg/day (n=15) or 3mg cetrorelix acetate (n=15) in luteal phase before subsequent antagonist protocol. Participants were re-evaluated as on control/day 3.
Results: There was a significant reduction of mean follicular sizes in each group after medical intervention (7.63±2.11 Vs. 4.30±0.92 in group A and 8.73±1.96 Vs. 4.13±1.11 in group B) (p=0.0001). The magnitude of follicular size reduction was significantly higher in group B (-4.60±2.04 Vs. -3.33±2.28) (0.027). There was a non significant attenuation of follicular size discrepancies in two groups. FSH and inhibin B levels in the day 3 of the next cycle in both groups were significantly decreased but did not have significant difference between two groups.
Conclusion: Both luteal E2 and premenstrual GnRH antagonist administration reduces the follicular sizes significantly and GnRH antagonist acts more potently than E2 in this way but attenuation of follicular size discrepancies in both treatment is not significant
Keywords: Follicular synchronization, Estradiol, GnRH antagonist
Full-Text [PDF 145 kb]   (813 Downloads) |   |   Full-Text (HTML)  (272 Views)  
Type of Study: Original Article |
References
1. McNatty KP, Hillier SG, Vanden Boogaard AM, Trimbos-Kemper TC, Reichert LE Jr, van Hall EV. Follicular development during the luteal phase of the human menstrual cycle. J Clin Endocrinol Metab 1983; 56: 22-31. [DOI:10.1210/jcem-56-5-1022]
2. Fauser BC, Van Heusden AM. Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocrinol Rev 1997; 18: 71-106. [DOI:10.1210/er.18.1.71]
3. Devreker F, Pogonici E, De llaertclaer V, Revelard P, Van den Bergh M, Englert Y. Selection of good embryos for transfer depends on embryo cohort size: implications for the 'mild ovarian stimulation' debate. Hum Reprod 1999; 14: 3002-3008. [DOI:10.1093/humrep/14.12.3002]
4. Tarlatzis BC, Fauser BC, Kolibianakis EM, Diedrich K, Rombauts L, Devroey P. GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update 2006; 12: 333-340. [DOI:10.1093/humupd/dml001]
5. Borm G, Mannaerts B. Treatment with the gonadotrophin‌ releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a con‌trolled, randomized, multicentre trial. The European Orgalutran Study Group. Hum Reprod 2000; 15: 1490-1498. [DOI:10.1093/humrep/15.7.1490]
6. AI-Inany H, Aboulghar M. Gonadotrophin-releasing hor-mone antagonists for assisted conception. Cochrane Database Systemic Rev 2001; 4: CD001750.
7. Fanchin R, Schonauer LM, Cunha-Filho JS, Lozano DHM, Frydman R. Coordination of Antral Follicle Growth: Basis for Innovative Concepts of Controlled Ovarian Hyperstimulation. Semin Reprod Med J 2005; 23: 354-362. [DOI:10.1055/s-2005-923393]
8. Fanchin R, Salomon L, Castelo-Branco A, Olivennes F, Frydman N, Frydman R. Luteal estradiol pre-treatment coordinates follicular growth during controlled ovarian hyper-stimulation with GnRH antagonists. Hum Reprod 2003; 18: 2698-2703. [DOI:10.1093/humrep/deg516]
9. Fanchin R, Branco AC, Kadoch IJ, Hosny G, Bagirova M, Frydman R. Premenstrual administration of gonadotropin-releasing hormone antagonist coordinates early antral follicle sizes and sets up the basis for an innovative concept of controlled ovarian hyperstimulation. Fertil Steril 2004; 81: 1554-1558. [DOI:10.1016/j.fertnstert.2003.11.037]
10. Sharara FI, McClamrock HD. The effect of aging on ovarian volume measurements in infertile women. Obstet Gynecol 1999; 94: 57-60.
11. Cédrin-Durnerin I, Bständig B, Parneix I, Bied-Damon V, Avril C, Decanter C, et al. Effects of oral contraceptive, synthetic progestrogen or natural estrogen pre-treatments on the hormonal profile and the antral follicle cohort befor GNRH antagonist protocol. Hum Reprod 2007; 22: 109-116. [DOI:10.1093/humrep/del340]
12. Obruca A, Fischl FH, Huber Jc, Programming oocyte retrival using oral contraceptive pretreatment before ovarian stimulation with a GNRH antagonist (Cerotide) protocol. Hum Reprod 2001; 16 (Suppl.): 89.
13. Smulders B, Van Oirschot SM, Farquhar C, Rombauts L, Kremer JA. Oral contraceptive pill, progestogen or estrogen pre-treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 2010; 20:CD006109. [DOI:10.1002/14651858.CD006109.pub2]
14. Fanchin R, Salomon L, Castelo- Branco A, Olivennes F, Frydman N, Frydman R. Luteal estradiol pre-treatment coordinate follicular growth during controlled ovarian hyperstimulation with GNRH antagonist. Hum Reprod 2003; 18: 2698-2703. [DOI:10.1093/humrep/deg516]
15. Elassar A, Mann JS, Engmann L, Nulsen J, Benadiva C. Luteal phase estradiol versus luteal phase estradiol and antagonist protocol for controlled ovarian stimulation before in-vitro fertilization in poor responders. Fertil Steril 2011; 95: 324-326. [DOI:10.1016/j.fertnstert.2010.07.1058]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb