Volume 11, Issue 3 (5-2013)                   IJRM 2013, 11(3): 185-0 | Back to browse issues page

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Ramezani Tehrani F, Daneshpour M, Hashemi S, Zarkesh M, Azizi F. Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS. IJRM 2013; 11 (3) :185-0
URL: http://ijrm.ir/article-1-398-en.html
Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS
Fahimeh Ramezani Tehrani * 1, Maryam Daneshpour2 , Somayeh Hashemi3 , Maryam Zarkesh2 , Feridoun Azizi4
1- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , ramezani@endocrine.ac.ir
2- Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (2900 Views)
Background: Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology.
Objective: We examined the possible association of adiponectin and insulin receptor gene polymorphisms with PCOS.
Materials and Methods: A total of 186 women with PCOS using NIH criteria and 156 healthy women were recruited. Their samples were genotyped for the polymorphism in exon 17 and 8 of the insulin receptor gene or exon and intron 2 of the adiponectin gene.
Results: The distributions of genotypes and alleles of both polymorphisms were not different in women with PCOS and controls. There was no significant differences on the anthropometric and hormonal profiles of various adiponectin and insulin receptor genes polymorphisms among both groups.
Conclusion: Adiponectin and insulin receptor gene polymorphisms are not associated with PCOS in a sample of Iranian population.
Keywords: Receptor, Insulin/ genetics, Adiponectin/ genetics, Polycystic ovary syndrome, Polymorphism, Genetic/ genetics.
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Type of Study: Original Article |
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