Volume 11, Issue 8 (11-2013)                   IJRM 2013, 11(8): 653-0 | Back to browse issues page

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Mutalip S S M, Singh G K S, Shah A M, Mohamad M, Mani V, Hussin S N. Histological changes in testes of rats treated with testosterone, nandrolone, and stanozolol. IJRM 2013; 11 (8) :653-0
URL: http://ijrm.ir/article-1-446-en.html
Histological changes in testes of rats treated with testosterone, nandrolone, and stanozolol
Siti Syairah Mohd Mutalip * 1, Gurmeet Kaur Surindar Singh2 , Aishah Mohd Shah2 , Mashani Mohamad2 , Vasudevan Mani2 , Siti Nooraishah Hussin2
1- Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia , syairah@salam.uitm.edu.my
2- Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia
Abstract:   (2134 Views)
Background: Anabolic androgenic steroids (AAS) is being used in medical treatments, but AAS also was identified to have the risks of adverse effects towards patients and consumers health.
Objective: Present study was conducted to observe the effects of testosterone, nandrolone, and stanozolol (forms of AAS) intake during onset of puberty on the rat testicular histology.
Materials and Methods: Juvenile male Sprague-Dawley (SD) rats (n=42) were divided into seven groups and were injected subcutaneously with medium dose of polyethylene glycol-200 (PEG-200) (control), testosterone, nandrolone, and stanozolol for six weeks (PND 41-87). The animals were weighed daily and sacrificed on PND 88. Testes were removed, weighed, and prepared for histological assessment and finally specimens were observed under microscope.
Results: The results showed an insignificant increase in mean daily body weight with highest and lowest body weight gained was of 177.6±1.69 gr and 140.0±12.26 gr respectively. There was significant decrease in the testes absolute weight (p≤0.01) in all experimental groups except in the nandrolone 2.5 mg/kg/week treated group. Testicular histology of rats treated with AAS also showed slight changes in the uniformity of arrangements of seminiferous tubules.
Conclusion: Data from present study suggests that AAS have been initiating the adverse effects on testicular normal functions in rats during onset of puberty.
Keywords: Testosterone, Nandrolone, Stanozolol, Testes, Substance abuse.
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Type of Study: Original Article |
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