Volume 13, Issue 4 (5-2015)                   IJRM 2015, 13(4): 215-220 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Taghizadeh E, Kalantar S M, Mahdian R, Sheikhha M H, Farashahi-Yazd E, Ghasemi-Esmailabad S et al . SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique. IJRM 2015; 13 (4) :215-220
URL: http://ijrm.ir/article-1-643-en.html
SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique
Eskandar Taghizadeh1 , Seyed Mehdi Kalantar2 , Reza Mahdian3 , Mohammad Hasan Sheikhha1 , Ehsan Farashahi-Yazd1 , Saeed Ghasemi-Esmailabad1 , Zahra Shahbazi * 4
1- Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran
4- Pasteur Institute of Iran, Tehran, Iran , z_shahbazi@pasteur.ac.ir
Abstract:   (2466 Views)
Background: Sulfatase 1 ( SULF1 ) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.
Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique.
Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.
Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).
Conclusion: These findings suggest that SULF1 genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.
Keywords: SULF1 gene, Polymerase chain reaction, Restriction fragment length Polymorphysm, Single nucleotide polymorphism, Restriction endonucleases, rs6990375.
Full-Text [PDF 662 kb]   (519 Downloads) |   |   Full-Text (HTML)  (388 Views)  
Type of Study: Original Article |
References
1. Allan T, Morris JK, Parslow W. Factors that affect outcome of in-vitro fertilisation treatment. Lancet 1996; 348: 1402-1406. [DOI:10.1016/S0140-6736(96)05291-9]
2. Elder K, Dale B. In-vitro fertilization. Cambridge University Press; 2010. [DOI:10.1017/CBO9780511984761]
3. Porcu E, Fabbri R, Seracchioli R, Ciotti PM, Magrini O, Flamigni C. Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. Fertil Steril 1997; 68: 724-726. [DOI:10.1016/S0015-0282(97)00268-9]
4. Norwitz ER, Schust DJ, Fisher SJ. Implantation and the Survival of Early Pregnancy. N Engl J Med 2001; 345: 1400-1408. [DOI:10.1056/NEJMra000763]
5. Edwards RG. Physiological and molecular aspects of human implantation. Hum Reprod 1995; 10 (Suppl.): 1-13. [DOI:10.1093/humrep/10.suppl_2.1]
6. Hardy K, Spanos S. Growth factor expression and function in the human and mouse preimplantation embryo. J Endocrinol 2002; 172: 221-236. [DOI:10.1677/joe.0.1720221]
7. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. J Endocrinol 2011; 210: 5-14. [DOI:10.1530/JOE-10-0461]
8. Sarrazin S, Lamanna WC, Esko JD. Heparan sulfate proteoglycans. Cold Spring Harbor Perspect Biol 2011; 3: a004952. [DOI:10.1101/cshperspect.a004952]
9. Bernfield M, Götte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, et al. Functions of cell surface heparan sulfate proteoglycans. Ann Rev Biochem 1999; 68: 729-777. [DOI:10.1146/annurev.biochem.68.1.729]
10. David G. Integral membrane heparan sulfate proteoglycans. FASEB J 1993; 7: 1023-1030. [DOI:10.1096/fasebj.7.11.8370471]
11. Hur K, Han TS, Jung EJ, Yu J, Lee HJ, Kim WH, et al. Up‐regulated expression of sulfatases (SULF1 and SULF2) as prognostic and metastasis predictive markers in human gastric cancer. J Pathol 2012; 228: 88-98. [DOI:10.1002/path.4055]
12. Han CH, Huang YJ, Lu KH, Liu Z, Mills GB, Wei Q, et al. Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer. J Exp Clin Cancer Res 2011; 30: 5. [DOI:10.1186/1756-9966-30-5]
13. Holst CR, Bou-Reslan H, Gore BB, Wong K, Grant D, Chalasani S, et al. Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS One 2007; 2: e575. [DOI:10.1371/journal.pone.0000575]
14. Lai JP, Sandhu DS, Shire AM, Roberts LR. The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis. J Gastrointest Cancer 2008; 39: 149-158. [DOI:10.1007/s12029-009-9058-y]
15. Sheikhha MH, Taghizadeh E, Mahmoodi MB, Kalantar SM. Impact of SULF1 Gene on Angiogenesis. Iran J Diabetes Obesity 2012; 4: 191-201.
16. Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive. Fertil Steril 2003; 80: 1371-1375. [DOI:10.1016/j.fertnstert.2003.05.003]
17. Klerk C, Macklon NS, Heijnen EM, Eijkemans MJ, Fauser BC, Passchier J, Hunfeld JA. The psychological impact of IVF failure after two or more cycles of IVF with a mild versus standard treatment strategy. Hum Reprod 2007; 22: 2554-2558. [DOI:10.1093/humrep/dem171]
18. Han CH, Huang YJ, Lu KH, Liu Z, Mills GB, Wei Q, et al. Polymorphism in the SULF1 gene are associated with early age of onset and survival of ovarian cancer. J Exp Clin Cancer Res 2011; 30: 5. [DOI:10.1186/1756-9966-30-5]
19. Zahraei M, Sheikhha MH, Kalantar SM, Ghasemi N, Jahaninejad T, Rajabi S, et al. The association of arylendosulfatase 1 (SULF1) gene polymorphism with recurrent miscarriage. J Assist Reprod Genet 2013; 31: 157. [DOI:10.1007/s10815-013-0150-7]
20. Paul A, Dawson PA. Sulfate in fetal development. Semin Cell Dev Biol 2011; 22: 653-659. [DOI:10.1016/j.semcdb.2011.03.004]
21. Lum DH, Tan J, Rosen SD, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol 2007; 27: 678-688. [DOI:10.1128/MCB.01279-06]
22. Schratt G. MicroRNAs at the synapse. Nat Rev Neurosci 2009; 10: 842-849. [DOI:10.1038/nrn2763]
23. Lai JP, Sandhu DS, Shire AM, Roberts LR. The Tumor Suppressor Function of Human Sulfatase 1 (SULF1) in Carcinogenesis. J Gastrointest Cancer 2008; 39: 149-158. [DOI:10.1007/s12029-009-9058-y]
24. Gill RS, Day A, Barstow A, Zaman G, Chenu C, Dhoot GK. Mammalian Sulf1 RNA alternative splicing and its significance to tumour growth regulation. Tumour Biol 2012; 15:1669-1680. [DOI:10.1007/s13277-012-0423-2]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb