Volume 13, Issue 6 (8-2015)                   IJRM 2015, 13(6): 373-378 | Back to browse issues page

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Moti M, Amini L, Mirhoseini Ardakani S S, Kamalzadeh S, Masoomikarimi M, jafarisani M. Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome. IJRM 2015; 13 (6) :373-378
URL: http://ijrm.ir/article-1-654-en.html
Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome
Mahtab Moti1 , Leila Amini2 , Soheila Sadat Mirhoseini Ardakani3 , Sara Kamalzadeh3 , Masoomeh Masoomikarimi4 , Moslem Jafarisani * 5
1- Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
2- Faculty of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
3- Department of Biology, College of Basic Sciences, Karaj Branch, Islamic Azad University, Alborz, Iran
4- Department of Immunology, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
5- Department of Biochemistry, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran , moslem.jafarisani@gmail.com
Abstract:   (2580 Views)
Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.
Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran.
Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.
Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.
Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
Keywords: Polycystic ovary syndrome, Infertility, CRP, Antioxidant, AOPP
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Type of Study: Original Article |
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