Volume 15, Issue 2 (3-2017)                   IJRM 2017, 15(2): 87-92 | Back to browse issues page

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Ghasemi N, Dehghani Firouzabadi R, Ahmadi S. Association of -460C/T and +405 G/C polymorphisms of vascular endothelial growth factor gene and susceptibility of ovarian hyperstimulation syndrome. IJRM 2017; 15 (2) :87-92
URL: http://ijrm.ir/article-1-802-en.html
Association of -460C/T and +405 G/C polymorphisms of vascular endothelial growth factor gene and susceptibility of ovarian hyperstimulation syndrome
Nasrin Ghasemi * 1, Razieh Dehghani Firouzabadi2 , Shahnaz Ahmadi3
1- Recurrent Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , nghasemi479@gmail.com
2- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (2906 Views)
Background: Ovarian hyperstimulation syndrome (OHSS) is one of the most important complications of assisted reproduction treatment (ART). Many substances are involved in the regulation of the vascular permeability, which have been concerned to cause OHSS. Vascular endothelial growth factor (VEGF) has emerged as one of the main angiogenic factors, which could be responsible for increased vascular permeability.
Objective: This project evaluated potential association between OHSS and VEGF gene -460 C/T and +405 G/C polymorphism.
Materials and Methods: This case-control study was performed at Research and Clinical Center for Infertility, Yazd, Iran for one year. One hundred sixty women enrolled in this study, which were received conventional stimulation. Eighty five of 160 patients were normoresponder (control group) and seventy five were OHSS (case group). After DNA extraction from whole blood by salting-out method, VEGF gene polymorphisms were amplified by PCR-RFLP.
Results: There were no significant difference in the frequency of -460 C/T polymorphism between cases and controls (Chi-square test, p=0.85). The frequency of +405 G/C was significantly higher in the OHSS group (p=0.03, OR=2.44; 95% CI=1.23-4.82).
Conclusion: In women who developed OHSS, VEGF gene polymorphism +405 could be effective. Two of the polymorphisms -460 C/T and +405 G/C were reported to be associated with increased VEGF basal promoter activity. However, only +405 G/C gene polymorphisms was more frequent in cases than controls
Keywords: Ovarian hyperstimulation syndrome, Vascular endothelial growth factor, Gene polymorphism.
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Type of Study: Original Article |
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