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Volume 15, Issue 3 (5-2017)
IJRM 2017, 15(3): 155-160 |
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Soheilykhah S, Mojibian M, Jannati Moghadam M. Serum ferritin concentration in early pregnancy and risk of subsequent development of gestational diabetes: A prospective study. IJRM 2017; 15 (3) :155-160
URL: http://ijrm.ir/article-1-805-en.html
URL: http://ijrm.ir/article-1-805-en.html
1- Endocrine Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , s_soheilykhah@yahoo.com
2- Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Obstetrics and Gynecology, Mojibian Hospital, Yazd, Iran
2- Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Obstetrics and Gynecology, Mojibian Hospital, Yazd, Iran
Abstract: (6435 Views)
Background: Elevated serum ferritin concentration is associated with insulinresistance and diabetes. Recently it has also been described in gestational diabetesmellitus (GDM).
Objective: A prospective study was done to determine whether there was arelationship between serum ferritin concentration in early pregnancy and the risk ofGDM.
Materials and Methods: A study was performed on 1,384 pregnant women withgestational age of 12-16 weeks. A blood sample was obtained for measurement offerritin in the first trimester. Diagnosis of GDM was done by 75 gr oral glucosetolerance test between 24-28 wk.
Results: Women who developed GDM had a higher concentration of serum ferritinthan women who did not develop GDM (p=0.01). A ferritin concentration of 45ng/ml was calculated to be the 75th percentile for healthy pregnant women.Considering this level 32% in the GDM group and 25.2%of normal subjectsexhibited high ferritin levels (p=0.01). The risk of GDM with these high levels offerritin was 1.4-fold higher than that for subjects with lower concentrations. The Odds Ratio was 1.4 (95% CI= 1-1.87) (p=0.01). After adjusted for age Odds Ratiowas 1.38 (95% CI=1.02-1.86) (p=0.03) and after adjustment for pre-pregnancy BodyMass index, the adjusted odds ratio was 1.31 (CI= 0.96-1.79) (p=0.08). Aftermultivariable adjustment (age and body mass index), the adjusted odds ratio was 1.3(0.95-1.8) (p=0.09).
Conclusion: High serum ferritin can be regarded as a significant risk factor for thedevelopment of gestational diabetes
Objective: A prospective study was done to determine whether there was arelationship between serum ferritin concentration in early pregnancy and the risk ofGDM.
Materials and Methods: A study was performed on 1,384 pregnant women withgestational age of 12-16 weeks. A blood sample was obtained for measurement offerritin in the first trimester. Diagnosis of GDM was done by 75 gr oral glucosetolerance test between 24-28 wk.
Results: Women who developed GDM had a higher concentration of serum ferritinthan women who did not develop GDM (p=0.01). A ferritin concentration of 45ng/ml was calculated to be the 75th percentile for healthy pregnant women.Considering this level 32% in the GDM group and 25.2%of normal subjectsexhibited high ferritin levels (p=0.01). The risk of GDM with these high levels offerritin was 1.4-fold higher than that for subjects with lower concentrations. The Odds Ratio was 1.4 (95% CI= 1-1.87) (p=0.01). After adjusted for age Odds Ratiowas 1.38 (95% CI=1.02-1.86) (p=0.03) and after adjustment for pre-pregnancy BodyMass index, the adjusted odds ratio was 1.31 (CI= 0.96-1.79) (p=0.08). Aftermultivariable adjustment (age and body mass index), the adjusted odds ratio was 1.3(0.95-1.8) (p=0.09).
Conclusion: High serum ferritin can be regarded as a significant risk factor for thedevelopment of gestational diabetes
Keywords: Ferritin, Gestational Diabetes.
Type of Study: Original Article |
References
1. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1996; 1275: 161-203. [DOI:10.1016/0005-2728(96)00022-9]
2. Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood 2002; 99: 3505-3516. [DOI:10.1182/blood.V99.10.3505]
3. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 1974; 290:1213-1216. [DOI:10.1056/NEJM197405302902201]
4. Kaneshige E. Serum ferritin as an assessment of iron stores and other hematologic parameters during pregnancy. Obstet Gynecol 1981; 57: 238-242.
5. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dialysis Transplant 2004; 19: 141-144. [DOI:10.1093/ndt/gfg493]
6. Williams MJA, Poulton R, Williams S. Relationship of serum ferritin with cardio-vascular risk factors and inflammation in young men and women. Atherosclerosis 2002; 165: 179-184. [DOI:10.1016/S0021-9150(02)00233-2]
7. Mainous AG III, Wells BJ, Everett CJ, GillJM, King DE. Association of ferritin and lipids with C-reactive protein. Am J Cardiol 2004; 93: 559-562. [DOI:10.1016/j.amjcard.2003.11.018]
8. Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, et al. Body iron storesare associated with serum insulin and blood glucose concentrations: populationstudy in 1,013 eastern Finnish men. Diabete Care 1997; 20: 426-428. [DOI:10.2337/diacare.20.3.426]
9. .Fernandez-Real JM, Ricart-Engel W, Casamitjana-Abella R, Cabrero D, Arroyo E, Fernandez-Castaner M, et al. Serum ferritin as a component of the insulin resistance syndrome. DiabetesCare 1998; 21: 62-68. [DOI:10.2337/diacare.21.1.62]
10. Ferrannini E. Insulin resistance, iron, and the liver. Lancet 2000;355: 2181-2182. [DOI:10.1016/S0140-6736(00)02397-7]
11. Ford ES, Cogswell ME. Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care 1999; 22: 1978-1983. [DOI:10.2337/diacare.22.12.1978]
12. Jiang R, Manson JE, Meigs JB, Ma J, RifaiN, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 2004; 291: 711-717. [DOI:10.1001/jama.291.6.711]
13. Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 2002; 51: 2348-2354. [DOI:10.2337/diabetes.51.8.2348]
14. Sharifi F, Mousavinasab SN, Jazebizadeh H. Elevated serum ferritin concentrations in pre-diabetic subjects. Diab Vasc Dis Res 2008; 5: 15-18. [DOI:10.3132/dvdr.2008.003]
15. Sharifi F, Sazandeh SH. Serum ferritin in type 2 diabetes mellitus and its relationship with HbA1c. Acta Medical Iranica 2004; 42: 142-145.
16. Lao TT, Chan PL, Tam KF. Gestational diabetes mellitus in the last trimester a feature of maternal iron excess? Diabet Med 2001; 18: 218-223. [DOI:10.1046/j.1464-5491.2001.00453.x]
17. Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: The Camden study. Diabetes Care 2006; 29: 1077-1082. [DOI:10.2337/dc06-0164]
18. Lao TT, Tam KF. Maternal serum ferritin and gestational impaired glucose tolerance. Diabetes Care 1997; 20: 1368-1313. [DOI:10.2337/diacare.20.9.1368]
19. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013; 36 (Suppl.): S67. [DOI:10.2337/dc13-S067]
20. Shimin FU, MM, Feifei LI, Zhiping Liu. The relationship between body iron status, iron intake and gestational diabetes (A systematic Review and Meta-Analysis). Medicine 2016: 95: e2383 [DOI:10.1097/MD.0000000000002383]
21. Sharifi F, Ziaee A, Feizi A, Mousavinasab N, Anjomshoaa A, Mokhtari P. Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus. Diabetes Metab Syndr Obes 2010: 3; 413-419. [DOI:10.2147/DMSO.S15049]
22. Zein S, Rashidi S, Awada S, Osman M, Al-Hajje A, Shami N, et al. High iron level in early pregnancy increased glucose intolerance. J Trace Elem Biol 2015; 30: 220-225. [DOI:10.1016/j.jtemb.2014.09.004]
23. Amiri F, Basirat Z, Omidvar S, Majid Sharbatdaran M, Hajian Tilaki K, Mahdi Pouramir M. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes. J Nat Sci Biol Med 2013; 4: 302-305. [DOI:10.4103/0976-9668.116977]
24. Scholl OT. Iron status during pregnancy: Setting the stage for mother and infant. Am J Clin Nutr 2005; 81: 1218-1222.
25. Lao TT, Chan LY, Tam KF, Ho LF. Maternal hemoglobin and risk of gestational diabetes mellitus in Chinese women. Obstet Gynecol 2002; 99: 807-812.
26. Barbieri M, Ragno E, Benvenutti E, Zito GA, Corsi A, Ferrucci L. New aspects of the insulin resistance syndrome: Impact on haematological parameters. Diabetologia 2001; 44: 1232-1237. [DOI:10.1007/s001250100634]
27. Lund EK, Fairweather-Tait SJ, Wharf SG, Johnson IT. Chronic exposure to high levels of dietary iron fortification increases lipid peroxidation in the mucosa of the rat large intestine. J Nutr 2001; 131: 2928-2931. [DOI:10.1093/jn/131.11.2928]
28. Pierre JL, Fontecave M. Iron and activated oxygen species in biology: The basic chemistry. Biometals 1999; 12: 195-199. [DOI:10.1023/A:1009252919854]
29. De Frozo RA. The triumvirate: β-cells, muscle, liver: A collusion responsible for NIDDM. Diabetes 1988; 37: 667-687. [DOI:10.2337/diab.37.6.667]
30. Swaminathan S, Fonseca VA, Alam MG, Shah SV. The role of iron in diabetes and its complications. Diabetes care 2007; 30: 1926-1933 [DOI:10.2337/dc06-2625]
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