Volume 5, Issue 4 (7-2007)                   IJRM 2007, 5(4): 81-88 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Tokushige N, al-Jefout M, Salih H, Fraser I S. Endometrial nerve fibres in endometriosis. IJRM 2007; 5 (4) :81-88
URL: http://ijrm.ir/article-1-84-en.html
Endometrial nerve fibres in endometriosis
Natsuko Tokushige1 , Moamar Al-Jefout1 , Hilmy Salih1 , Ian S Fraser * 2
1- Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Australia
2- Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Australia , helena@med.usyd.edu.au
Abstract:   (1988 Views)
Endometriosis is a common gynaecological disease that can cause severe pelvic pain such as dysmenorrhoea and dyspareunia, however the mechanisms by which pain is generated are not well understood. Nerve fibres in endometriotic plaques have been reported by several authors. We have recently demonstrated the presence of unmyelinated sensory nerve fibres (using the pan-neuronal marker PGP9.5) in the functional layer of endometrium in women with endometriosis and a significantly increased nerve fibre density in endometrium and myometrium in women with endometriosis compared with women without endometriosis. Sensory C nerve fibres were only detected in the functional layer of endometrium of women with endometriosis and never in women without endometriosis. This finding is so consistent that it may become an effective means of making the diagnosis of endometriosis. Nerve fibres expressing a range of neuronal markers and an over-expression of nerve growth factor (NGF) and nerve growth factor receptor (NGFRp75) were also demonstrated in peritoneal endometrial plaques in women with endometriosis. Effects of currently available medications for endometriosis on nerve fibres in eutopic endometrium in hormonally treated women have been also studied. This review will describe nerve fibres in eutopic endometrium and ectopic endometriotic plaques in women with endometriosis.
Keywords: Nerve fibres, Endometriosis, Endometrium, Diagnosis
Full-Text [PDF 344 kb]   (483 Downloads) |   |   Full-Text (HTML)  (308 Views)  
Type of Study: Original Article |
References
1. Tokushige N, Markham R, Russell P, Fraser IS. High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis. Hum Reprod 2006; 21: 782-787. [DOI:10.1093/humrep/dei368]
2. Tokushige N, Markham R, Russell P, Fraser IS. Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis. Fertil Steril 2007; (In press). [DOI:10.1016/j.fertnstert.2006.12.078]
3. Tokushige N, Markham R, Russell P, Fraser IS. Nerve fibers in peritoneal endometriosis. Hum Reprod 2006; 21:3001-3007. [DOI:10.1093/humrep/del260]
4. Mantyh PW. Neurobiology of substance P and the NK1 receptor. J Clin Psychiatry 2002; 63 Suppl 11:6-10.
5. Schaible HG, Ebersberger A, Von Banchet GS. Mechanisms of pain in arthritis. Ann NY Acad Sci 2002; 966:343-354. [DOI:10.1111/j.1749-6632.2002.tb04234.x]
6. Amsterdam LL, Gentry W, Jobanputra S, Wolf M, Rubin SD, Bulun S. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril 2005; 84: 300-304. [DOI:10.1016/j.fertnstert.2005.02.018]
7. Bjorling DE, Beckman M, layton MK, Wang ZY. Odulation of nerve growth factor in peripheral organs by oestrogen and progesterone. Neuroscience 2002; 110:155-167. [DOI:10.1016/S0306-4522(01)00568-1]
8. Krizsan-Agbas D, Pedchenko T, Hasan W, Smith PG. Oestrogen regulates sympathetic neurite outgrowth by modulating brain derived neurotrophic factor synthesis and release by the rodent uterus. Eur J Neurosci 2003;18: 2760-2768. [DOI:10.1111/j.1460-9568.2003.03029.x]
9. Palter SF, Duleba A, Zreik T, DiStasio C, Mandel T, Guarnaccia M, Polcz T, Amesse L, Olive DL. Office Microlaparoscopy Under Local Anesthesia. J Am Assoc Gynecol Laparosc 1996; 3: S38. [DOI:10.1016/S1074-3804(96)80264-7]
10. Almeida ODJr, Val-Gallas JM. Conscious pain mapping. J Am Assoc Gynecol Laparosc 1997;5: 587-590. [DOI:10.1016/S1074-3804(05)80093-3]
11. Demco L. Mapping the source and character of pain due to endometriosis by patient-assisted laparoscopy. J Am Assoc Gynecol Laparosc 1998; 5: 241-245. [DOI:10.1016/S1074-3804(98)80026-1]
12. Berkley KJ, Dmitrieva N, Curtis KS, Papka RE. Innervation of ectopic endometrium in a rat model of endometriosis. Proc Natl Acad Sci U S A 2004; 101: 11094-11098. [DOI:10.1073/pnas.0403663101]
13. Tamburro S, Canis M, Albuisson E, Dechelotte P, Darcha C, Mage G. Expression of transforming growth factor beta1 in nerve fibers is related to dysmenorrhea and laparoscopic appearance of endometriotic implants. Fertil Steril 2003;80: 1131-1136. [DOI:10.1016/S0015-0282(03)01182-8]
14. Tulandi T, Felemban A, Chen MF. Nerve fibers andhistopathology of endometriosis-harboring peritoneum. J Am Assoc Gynecol Laparosc 2001; 8: 95-98. [DOI:10.1016/S1074-3804(05)60556-7]
15. Ten Have S, Fraser IS, Markham R, Lam A, Matsumoto I. Proteomic analysis of protein expression in the eutopiuc endometrium of women with endometriosis. Proteomics 2007; ( In press). [DOI:10.1002/prca.200600743]
16. Lessey BA, Castelbaum AJ, Sawin SW, Buck CA, Schinnar R, Bilker W, Strom BL. Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab1994;79:643-649. [DOI:10.1210/jcem.79.2.7519194]
17. Ota H, Igarashi S, Hatazawa J, Tanaka T. Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil Steril 1997;68:23-28. [DOI:10.1016/S0015-0282(97)81470-7]
18. Healy DL, Rogers PA, Hii L, Wingfield M. Angiogenesis: a new theory for endometriosis. Hum Reprod Update 1998;4:736-740. [DOI:10.1093/humupd/4.5.736]
19. Jansen RPS, Russell P. Non-pigmented endometriosis: clinical, laparoscopic and pathologic definition. Am J Obstet Gynecol 1986;155:1154-1159. [DOI:10.1016/0002-9378(86)90136-5]
20. Al-jefout M, Andreadis N, Tokushige N, Markham R, Fraser IS. A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers. Am J Obstet Gynecol 2007;(In press). [DOI:10.1016/j.ajog.2007.04.032]
21. Bourdel N, Matsusaki S, Roman H, Lenglet Y, Botchorischvili R, Mage G, Canis M . Endometriosis in teenagers. Gynecol Obstet Fertil 2006;34:727-734. [DOI:10.1016/j.gyobfe.2006.07.008]
22. Marsh EE, Laufer MR. Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly. Fertil Steril 2005; 83: 758-760. [DOI:10.1016/j.fertnstert.2004.08.025]
23. Bulletti C, De Ziegler D, Polli V, Del Ferro E, Palini S, Flamigni C. Characteristics of uterine contractility during menses in women with mild to moderate endometriosis. Fertil Steril 2002;77:1156-1161. [DOI:10.1016/S0015-0282(02)03087-X]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb