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Reproductive Biomedicine
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Volume 18, Issue 2 (February 2020)
IJRM 2020, 18(2): 85-92 |
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Alavi N, Ebrahimi M, Akbari-Asbagh F. The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study. IJRM 2020; 18 (2) :85-92
URL: http://ijrm.ir/article-1-1220-en.html
URL: http://ijrm.ir/article-1-1220-en.html
1- Obstetrics and Gynecology Ward, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2- Obstetrics and Gynecology Ward, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran. , maeb214@yahoo.com
2- Obstetrics and Gynecology Ward, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran. , maeb214@yahoo.com
Abstract: (3956 Views)
Background: Vitamin D deficiency and infertility are two important health problems in Iran. Some studies suggest that vitamin D may influence Anti-Müllerian hormone (AMH) and antral follicle count (AFC) as an ovarian reserve.
Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC.
Materials and Methods: three hundred and five infertile women referred to the IVF Unit of Yas hospital, between July and December 2017, were enrolled in this cross-sectional study. The demographic characteristics of the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFC were recorded.
Results: Finally, 287 infertile women were included in the analysis with a mean age of 29.95 ± 4.73 yr (18-45 yr) and a mean Body mass indexof 25.11 ± 4.41 kg/m2. The median AMH and vitamin D levels were 3.20 and 22.82 ng/ml, respectively. Considering the cut-off level of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association between AMH and vitamin D levels (p = 0.161), even after adjusting for baseline variables (p = 0.182). A total of 120 patients had an AFC < 6 and 164 ≥ 6, which was not statistically different between the groups with normal level or deficient vitamin D (p = 0.133).
Conclusion: The present cross-sectional study showed no significant association between serum levels of vitamin D and AMH or AFC in infertile women, even after adjusting for baseline variables.
Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC.
Materials and Methods: three hundred and five infertile women referred to the IVF Unit of Yas hospital, between July and December 2017, were enrolled in this cross-sectional study. The demographic characteristics of the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFC were recorded.
Results: Finally, 287 infertile women were included in the analysis with a mean age of 29.95 ± 4.73 yr (18-45 yr) and a mean Body mass indexof 25.11 ± 4.41 kg/m2. The median AMH and vitamin D levels were 3.20 and 22.82 ng/ml, respectively. Considering the cut-off level of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association between AMH and vitamin D levels (p = 0.161), even after adjusting for baseline variables (p = 0.182). A total of 120 patients had an AFC < 6 and 164 ≥ 6, which was not statistically different between the groups with normal level or deficient vitamin D (p = 0.133).
Conclusion: The present cross-sectional study showed no significant association between serum levels of vitamin D and AMH or AFC in infertile women, even after adjusting for baseline variables.
Type of Study: Original Article |
Subject:
Reproductive Biology
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