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Volume 10, Issue 2 (7-2012)
IJRM 2012, 10(2): 161-163 |
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Fayaz A, Simani S, Fallahian V, Eslamifar A, Hazrati M, Farahtaj F, et al . Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis. IJRM 2012; 10 (2) :161-163
URL: http://ijrm.ir/article-1-258-en.html
URL: http://ijrm.ir/article-1-258-en.html
Ahmad Fayaz1 
, Susan Simani2 , Vida Fallahian * 3, Ali Eslamifar2 , Mahboob Hazrati2 , Firoozeh Farahtaj4 , Nader Howaizi4 , Peivand Biglari4
, Susan Simani2 , Vida Fallahian * 3, Ali Eslamifar2 , Mahboob Hazrati2 , Firoozeh Farahtaj4 , Nader Howaizi4 , Peivand Biglari4
1- WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
2- Treatment and Prevention of Rabies Center, Department of Vaccination, Pasteur Institute of Iran, Tehran, Iran
3- Treatment and Prevention of Rabies Center, Department of Vaccination, Pasteur Institute of Iran, Tehran, Iran , vida.1333@yahoo.com
4- WHO Collaborating Center for Reference and Research on Rabies, Pasteur
2- Treatment and Prevention of Rabies Center, Department of Vaccination, Pasteur Institute of Iran, Tehran, Iran
3- Treatment and Prevention of Rabies Center, Department of Vaccination, Pasteur Institute of Iran, Tehran, Iran , vida.1333@yahoo.com
4- WHO Collaborating Center for Reference and Research on Rabies, Pasteur
Abstract: (2699 Views)
Background: Rabies is a fatal infectious disease and rabies post-exposure prophylaxis is the method of choice for prevention of human rabies.
Case series: We report rabies antibody levels in cord blood and also in serum of pregnant women who were bitten by suspected animals to rabies and were immunized by purified Vero cell rabies vaccine (PVRV) and Human Rabies immunoglobulin (HRIG) serum. During the years of 2007-2010, six pregnant women by the age range of 22-35 years were admitted in treatment and prevention of rabies center in Pasture institute of Iran, in Tehran. Among them two cases were at first trimester, one at second trimester and three at third trimester of conception. The interval between biting with delivery was 5-265 days (mean 121 days).
Conclusion: Results of immunoglobulin illustrate that levels of rabies antibody in maternal sera with the fetus are not equal and uniform but it is proved that baby will find efficient immunity as well with minimum protective level of 0.5 IU/ml in all cases except a newborn whom had been born just 5 days after the mother’s immunization and in a shorter time than the appropriate immunization of the mother who had received her second vaccination courses.
Case series: We report rabies antibody levels in cord blood and also in serum of pregnant women who were bitten by suspected animals to rabies and were immunized by purified Vero cell rabies vaccine (PVRV) and Human Rabies immunoglobulin (HRIG) serum. During the years of 2007-2010, six pregnant women by the age range of 22-35 years were admitted in treatment and prevention of rabies center in Pasture institute of Iran, in Tehran. Among them two cases were at first trimester, one at second trimester and three at third trimester of conception. The interval between biting with delivery was 5-265 days (mean 121 days).
Conclusion: Results of immunoglobulin illustrate that levels of rabies antibody in maternal sera with the fetus are not equal and uniform but it is proved that baby will find efficient immunity as well with minimum protective level of 0.5 IU/ml in all cases except a newborn whom had been born just 5 days after the mother’s immunization and in a shorter time than the appropriate immunization of the mother who had received her second vaccination courses.
Type of Study: Original Article |
References
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