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Azimi C, Khaleghian M, Farzanfar F. A retrospective chromosome studies among Iranian infertile women: Report of 21 years. IJRM 2013; 11 (4) :315-0
URL: http://ijrm.ir/article-1-404-fa.html
URL: http://ijrm.ir/article-1-404-fa.html
بررسی کروموزومی در زنان نابارور به مدت 21 سال. International Journal of Reproductive BioMedicine. 1392; 11 (4) :315-0
چکیده: (2345 مشاهده)
مقدمه: ناباروری مشکل پزشکی مهمی محسوب و تقریبا در 15% از زوجین دیده میشود. نقش مهم عوامل ژنتیکی در ناباروری بطور فزایندهای شناسایی گردیده است. در سالهای اخیر، اهمیت ارزش انجام آزمایش کاریوتایپ در زوجین نابارور توصیه گردیده است.
هدف: قصد از انجام این مطالعه، تعیین ناهنجاریهای کروموزومی در بین خانمهای نابارور ایرانی بوده است.
مواد و روشها: در این مطالعه 21 ساله گذشتهنگر، برای اولین بار 896 خانمی که بهدلیل ناباروری به گروه ژنتیک انستیتوکانسر ایران، بین سالهای 1986 تا 2006 مراجعه نموده بودند، مطالعه گردیدند. برای آزمایش کروموزومی، نمونههای خون محیطی هپارینه، کشت داده شده و با روش نواری شکل بررسی گردیدند.
نتایج: از بین 896 بیمار، 710 نفر (79/24%) کاریوتایپ طبیعی، 48 نفر (5/37%) نشانگان ترنر و 45 نفر (5/03%) با جنسیت معکوس یعنی با کاریوتایپ 46,XY بودند. 93 نفر (10/36%) باقی مانده طیف وسیعی از ناهنجاریهای کروموزومی را نشان دادند.
نتیجهگیری: نتایج ما نشان داد که روشهای سیتوژنتیک استاندارد اولین انتخاب برای بررسی ژنتیکی زنان نابارور میباشد و میتواند نشاندهنده انواع زیادی از ناهنجاریهای کروموزومی باشد.
هدف: قصد از انجام این مطالعه، تعیین ناهنجاریهای کروموزومی در بین خانمهای نابارور ایرانی بوده است.
مواد و روشها: در این مطالعه 21 ساله گذشتهنگر، برای اولین بار 896 خانمی که بهدلیل ناباروری به گروه ژنتیک انستیتوکانسر ایران، بین سالهای 1986 تا 2006 مراجعه نموده بودند، مطالعه گردیدند. برای آزمایش کروموزومی، نمونههای خون محیطی هپارینه، کشت داده شده و با روش نواری شکل بررسی گردیدند.
نتایج: از بین 896 بیمار، 710 نفر (79/24%) کاریوتایپ طبیعی، 48 نفر (5/37%) نشانگان ترنر و 45 نفر (5/03%) با جنسیت معکوس یعنی با کاریوتایپ 46,XY بودند. 93 نفر (10/36%) باقی مانده طیف وسیعی از ناهنجاریهای کروموزومی را نشان دادند.
نتیجهگیری: نتایج ما نشان داد که روشهای سیتوژنتیک استاندارد اولین انتخاب برای بررسی ژنتیکی زنان نابارور میباشد و میتواند نشاندهنده انواع زیادی از ناهنجاریهای کروموزومی باشد.
نوع مطالعه: Original Article |
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