International Journal of
Reproductive Biomedicine
Sat, May 4, 2024
[Archive]
Volume 13, Issue 1 (1-2015)
IJRM 2015, 13(1): 23-26 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Vafaei H, Dalili M, Amin Hashemi S. Serum concentration of calcium, magnesium and zinc in normotensive versus preeclampsia pregnant women: A descriptive study in women of Kerman province of Iran. IJRM 2015; 13 (1) :23-26
URL: http://ijrm.ir/article-1-587-en.html
URL: http://ijrm.ir/article-1-587-en.html
1- Maternal-fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Clinical Research Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran , mdalili@kmu.ac.ir
3- Clinical Research Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
2- Clinical Research Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran , mdalili@kmu.ac.ir
3- Clinical Research Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
Abstract: (2417 Views)
Background: Preeclampsia is a disorder of pregnancy without any specific reasons that characterized by high blood pressure and large amounts of protein in the urine. This disorder is caused by multiple factors and finding any factor related to this disorder can help on time prevention of this disease.
Objective: In this study, serum levels of calcium (Ca), magnesium (Mg) and zinc (Zn) were evaluated in preeclampsia women and compared to normotensive ones.
Materials and Methods: This was a case-control study on 40 normotensive pregnancies as controls, 20 mild and 20 severe preeclamptic pregnancies as case groups. The women were studied in their 28-40 weeks of pregnancy. Simple random sampling was done based on inclusion and exclusion criteria and data were collected by blood sampling.
Results: The serum Ca levels of 4.96±0.62, 4.89±0.34, 5.05±0.35 mg/dL, Mg levels of 0.83±0.08, 0.85±0.11, 0.84±0.11 mg/dL and Zn levels of 107.55±22.74, 108.00±22.40, 107.50±22.30 mg/dL was detected in normotensive, mild and severe preeclampsia, respectively. Statistical analysis revealed that there were no significant differences between three groups in serum levels of Ca (p=0.6), Mg (p=0.827) and Zn (p=0.997).
Conclusion: The findings of this study showed that the assessment of serum Ca, Mg and Zn levels does not have any clinical values for predicting and/or managing of preeclampsia. However, based on the positive relationship between serum Ca and Mg concentration and the severity of preeclampsia in this study, we recommend assessment of serum levels of these two mineral elements as indices of the severity of preeclampsia.
Objective: In this study, serum levels of calcium (Ca), magnesium (Mg) and zinc (Zn) were evaluated in preeclampsia women and compared to normotensive ones.
Materials and Methods: This was a case-control study on 40 normotensive pregnancies as controls, 20 mild and 20 severe preeclamptic pregnancies as case groups. The women were studied in their 28-40 weeks of pregnancy. Simple random sampling was done based on inclusion and exclusion criteria and data were collected by blood sampling.
Results: The serum Ca levels of 4.96±0.62, 4.89±0.34, 5.05±0.35 mg/dL, Mg levels of 0.83±0.08, 0.85±0.11, 0.84±0.11 mg/dL and Zn levels of 107.55±22.74, 108.00±22.40, 107.50±22.30 mg/dL was detected in normotensive, mild and severe preeclampsia, respectively. Statistical analysis revealed that there were no significant differences between three groups in serum levels of Ca (p=0.6), Mg (p=0.827) and Zn (p=0.997).
Conclusion: The findings of this study showed that the assessment of serum Ca, Mg and Zn levels does not have any clinical values for predicting and/or managing of preeclampsia. However, based on the positive relationship between serum Ca and Mg concentration and the severity of preeclampsia in this study, we recommend assessment of serum levels of these two mineral elements as indices of the severity of preeclampsia.
Type of Study: Original Article |
References
1. Bahadoran P, Zendehdel M, Movahedian A, Zahraee RH. The relationship between serum zinc level and preeclampsia. Iran J Nurs Midwif Res 2010; 15: 120-124.
2. Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden AC. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2005; 119: 60-66. [DOI:10.1016/j.ejogrb.2004.06.033]
3. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, et al. Trial of calcium to prevent preeclampsia. New Eng J Med 1997; 337: 69-77. [DOI:10.1056/NEJM199707103370201]
4. MHTME. Mothers health office annual report. Tehran, The Ministry of Health, Treatment and Medical Education; 2006.
5. Serdar Z, Gur E, Develioglu O, Colakogullari M, Dirican M. Placental and decidual lipid peroxidation and antioxidant defenses in preeclampsia lipid peroxidation in preeclampsia. Pathophysiology 2002; 9: 21-25. [DOI:10.1016/S0928-4680(02)00052-4]
6. Ilhan N, Ilhan N, Simsek M. The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia. Clin Biochem 2002; 35: 393-397. [DOI:10.1016/S0009-9120(02)00336-3]
7. Diaz E, Halhali A, Luna C, Diaz L, Avila E, Larrea F. Newborn birth weight correlates with placental zinc, umbilical insulin-like growth factor I, and leptin levels in preeclampsia. Arch Med Res 2002; 33: 40-47. [DOI:10.1016/S0188-4409(01)00364-2]
8. Das B, Samanta S, Chaudhuri S. Assessment of serum magnesium and uric acid levels in women with normal pregnancy and pre-eclampsia in Rohilkhand region in Uttar Pradesh, India. Int J Health Sci Res 2014; 4: 35-42.
9. Idogun ES, Imarengiaye CO, Momoh SM. Extracellular calcium and magnesium in preeclampsia and eclampsia. Afr J Reprod Health 2007; 11: 89-94. [DOI:10.2307/25549719]
10. Aziz R, Mahboob T. Serum Calcium, Magnesium and parathyroid hormone in normal pregnant and pre-eclamptic women in Karachi. Pak J Hyperten 2014; 3: 143-145.
11. Liu J, Yang H, Shi H, Shen C, Zhou W, Dai Q, et al. Blood copper, zinc, calcium, and magnesium levels during different duration of pregnancy in Chinese. Biol Trace Elem Res 2010; 135: 31-37. [DOI:10.1007/s12011-009-8482-y]
12. Jain S, Sharma P, Kulshreshtha S, Mohan G, Singh S. The role of calcium, magnesium, and zinc in pre-eclampsia. Biol Trace Elem Res 2010; 133: 162-170. [DOI:10.1007/s12011-009-8423-9]
13. Borella P, Szilagyi A, Than G, Csaba I, Giardino A, Facchinetti F. Maternal plasma concentrations of magnesium, calcium, zinc and copper in normal and patological pregnancies. Sci Total Environ 1990; 99: 67-76. [DOI:10.1016/0048-9697(90)90212-D]
14. Akhtar S, Begum S, Ferdousi S. Calcium and zinc deficiency in preeclamptic women. J Bangladesh Soc Physiol 2011; 6: 94-99.
15. Malas NO, Shurideh ZM. Does serum calcium in pre-eclampsia and normal pregnancy differ? Saudi Med J 2001; 22: 868-871.
16. Harma M, Harma M, Kocyigit A. Correlation between maternal plasma homocysteine and zinc levels in preeclamptic women. Biol Trace Elem Res 2005; 104: 97-105. [DOI:10.1385/BTER:104:2:097]
17. Kanagal DV, Rajesh A, Rao K, Devi UH, Shetty H, Kumari S, et al. Levels of serum calcium and magnesium in pre-eclamptic and normal pregnancy: A study from Coastal India. J Clin Diagn Res 2014; 8: 1-4. [DOI:10.7860/JCDR/2014/8872.4537]
18. Adam B, Malatyalioglu E, Alvur M, Talu C. Magnesium, zinc and iron levels in pre-eclampsia. J Matern Fetal Neonatal Med 2001; 10: 246-250. [DOI:10.1080/jmf.10.4.246.250-14]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
