دوره 13، شماره 4 - ( 2-1394 )                   جلد 13 شماره 4 صفحات 226-221 | برگشت به فهرست نسخه ها

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Yıldız M, Vural M, Emin Erdal M, İzci Ay Ö, Görücü Yılmaz Ş, Fatih Karababa İ et al . Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders. IJRM 2015; 13 (4) :221-226
URL: http://ijrm.ir/article-1-636-fa.html
عدم وجود ارتباط بین پلی مورفیسمهای DRD3, CNR1 و ناهنجاریهای دیس مورفیک قبل از قاعدگی. International Journal of Reproductive BioMedicine. 1394; 13 (4) :221-226

URL: http://ijrm.ir/article-1-636-fa.html


چکیده:   (2307 مشاهده)
مقدمه: ناهنجاری های دیس مورفیک قبل از قاعدگی (PMDD) از جمله ناهنجاری خلقی هستند که با علائم فیزیکال و موثر در طی فاز لوتئال در خانم های متعدد رخ می دهد.
هدف: هدف این مقاله بررسی ارتباط بین پلی مورفیسم DRD3 و پلی مورفیسم CNR1 با PMDD می باشد.
مواد و روش ها: 51 بیمار با PMDD بر اساس معیارهای DSM IV و 51 نمونه کنترل سالم در این مطالعه cross sectional وارد شدند. علائم بوسیله خود آزمایی روزانه، فرم های قبل قاعدگی ماهیانه و مصاحبه روانشناسی اندازه گیری شد.ژئوتیپ DRD3 و CNR1 بوسیله روش Taqmanfluorogenic مشخص شد.
نتایج: شیوع پلی مورفیسم های DRD3 و CNR1 بین بیماران و گروه کنترل تفاوتی نداشت.
نتیجه گیری: یافته های ما تایید کننده نقش موثری برای پلی مورفیسم های DRD3 و CNR1 در استعداد ابتلا به PMDD نبود.
نوع مطالعه: Original Article |

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