Volume 13, Issue 4 (5-2015)                   IJRM 2015, 13(4): 203-208 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mirzaei F, Amiri Moghadam T, Arasteh P. Comparison of serum 25-hydroxy vitamin D levels between mothers with small for gestational age and appropriate for gestational age newborns in Kerman. IJRM 2015; 13 (4) :203-208
URL: http://ijrm.ir/article-1-641-en.html
1- Department of Obstetrics and Gynecology, Physiology Research Center, Afzalipoor Hospital, Kerman University of Medical Sciences, Kerman, Iran , f_mirzaei@kmu.ac.ir
2- Department of Obstetrics and Gynecology, Afzalipoor Hospital, Kerman University of Medical Sciences, Kerman, Iran
3- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (2420 Views)
Background: Vitamin D deficiency during pregnancy is associated with some adverse pregnancy outcomes but its relationship with fetal growth is unknown.
Objective: We compared the 25-hydroxy vitamin D levels between mothers and their small for gestational age (SGA) newborns with mothers and their appropriate for gestational age (AGA) newborns.
Materials and Methods: The study population included pregnant women that referred to Afzalipour Hospital in Kerman from 2012 to 2013. The case and control group consisted of 40 pregnant mothers with SGA and AGA newborns, respectively. The maternal and infants 25-hydroxy vitamin D levels were measured in the two groups.
Results: 25-hydroxy vitamin D deficiency (<20 ng/ml) was statistically higher in women with SGA newborns in comparison to women with AGA newborns (p=0.003).Vitamin D deficiency was higher among the SGA newborns in comparison to AGA newborns (25% vs. 17.5%), although this finding was not statistically meaningful (p=0.379). The relationship of vitamin D deficiency levels between mothers and infants in both the SGA group and the AGA group was significant.
Conclusion: Our study reveals a high prevalence of vitamin D deficiency in women with SGA infants in comparison to women with AGA children. In addition, maternal vitamin D deficiency is associated with its deficiency in newborns.
Full-Text [PDF 421 kb]   (704 Downloads) |   |   Full-Text (HTML)  (368 Views)  
Type of Study: Original Article |

References
1. Gernand AD, Simhan HN, Klebanoff MA, Bodnar LM. Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study. J Clin Endocrinol Metab 2013; 98: 398-404. [DOI:10.1210/jc.2012-3275]
2. Pérez-López FR. Vitamin D: the secosteroid hormone and human reproduction. Gynecol Endocrinol 2007; 23: 13-24. [DOI:10.1080/09513590601045629]
3. Haugen M, Brantsaeter AL, Trogstad L, Alexander J, Roth C, Magnus P, et al. Vitamin D supplement and reduced risk of preeclampsia in nulliparous women. Epidemiology 2009; 20: 720-726. [DOI:10.1097/EDE.0b013e3181a70f08]
4. Camargo Jr CA, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics 2011; 127: 180-187. [DOI:10.1542/peds.2010-0442]
5. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol 2010; 203: 366. [DOI:10.1016/j.ajog.2010.06.036]
6. Fernández-Alonso AM, Dionis-Sánchez EC, Chedraui P, González-Salmerón MD, Pérez-López FR. Spanish Vitamin D and Women's Health Research Group. First-trimester maternal serum 25-hydroxyvitamin D3 status and pregnancy outcome. Int J Gynaecol Obstet 2012; 116: 6-9. [DOI:10.1016/j.ijgo.2011.07.029]
7. Powe C, Seely E. First Trimester Vitamin D, Vitamin D Binding Protein, and Subsequent Preeclampsia. Hypertension 2010; 56: 758-763. [DOI:10.1161/HYPERTENSIONAHA.110.158238]
8. Baker A, Haeri S. A Nested Case-Control Study of Midgestation Vitamin D Deficiency and Risk of Severe Preeclampsia. J Clin Endocrinol Metab 2010; 95: 5105-5109. [DOI:10.1210/jc.2010-0996]
9. Bodnar LM, Catov JM, Zmuda JM, Cooper ME, Parrott MS, Roberts JM, et al. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 2010; 140: 999-1006. [DOI:10.3945/jn.109.119636]
10. Burris HH, Rifas-Shiman SL, Camargo CA Jr, Litonjua AA, Huh SY, Rich-Edwards JW, et al. Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants. Ann Epidemiol 2012; 22: 581-586. [DOI:10.1016/j.annepidem.2012.04.015]
11. Van den Berg G, van Eijsden M, Vrijkotte TG, Gemke RJ. Suboptimal maternal vitamin D status and low education level as determinants of small-for-gestational-age birth weight. Eur J Nutr 2013; 52: 273-279. [DOI:10.1007/s00394-012-0327-3]
12. Ertl R, Yu CK, Samaha R, Akolekar R, Nicolaides KH. Maternal serum vitamin D at 11-13 weeks in pregnancies delivering small for gestational age neonates. Fetal Diagn Ther 2012; 31: 103-108. [DOI:10.1159/000333810]
13. Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network. Am J Obstet Gynecol 2000; 182: 198-206. [DOI:10.1016/S0002-9378(00)70513-8]
14. Peleg D, Kennedy C, Hunter S. Intrauterine Growth Restriction: Identification and Management. Am Fam Physician 1998; 58: 453-460.
15. Gardosi J. New definition of small for gestational age based on fetal growth potential. Horm Res 2006; 3: 15-18. [DOI:10.1159/000091501]
16. Morley R, Carlin JB, Pasco JA, Wark JD, Ponsonby AL. Maternal early pregnancy vitamin D concentration and offspring birth size: effect modification by infant VDR genotype. Eur J Clin Nutr 2009; 63: 802-804. [DOI:10.1038/ejcn.2008.55]
17. Song SJ, Zhou L, Sh S, Liu J, Zhou J, Feng K, et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013; 8(12)e85081. [DOI:10.1371/journal.pone.0085081]
18. Morley R, Carlin JB, Pasco JA, Wark JD, Ponsonby AL. Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype. Eur J Clin Nutr 2009; 63: 802-804. [DOI:10.1038/ejcn.2008.55]
19. Sahu M, Bhatia V, Aggarwal A, Rawat V, Saxena P, Pandey A, et al. Vitamin D deficiency in rural girls and pregnant women despite abundant sunshinein northern India. Clin Endocrinol 2009; 70: 680-684. [DOI:10.1111/j.1365-2265.2008.03360.x]
20. Nicolaidou P, Hatzistamatiou Z, Papadopoulou A, Kaleyias J, Floropoulou E, Lagona E, et al. Low vitamin D status in mother newborn pairs in Greece. Calcif Tissue Int 2006; 78: 337-342. [DOI:10.1007/s00223-006-0007-5]
21. Salek M, Hashemipour M, Aminorroaya A, Gheiratmand A, Kelishadi R, Ardestani PM, et al. Vitamin D deficiency among pregnant women and their newborns in Isfahan, Iran. Exp Clin Endocrinol Diabetes 2008; 116: 352-356. [DOI:10.1055/s-2008-1042403]
22. Dror DK, Alen LH. Vitamin D inadequacy in pregnancy: biology, outcoms, and interventions. Nutr Rev 2010; 68; 465-477. [DOI:10.1111/j.1753-4887.2010.00306.x]
23. Cardus A, Panizo S, Encinas M, Dolcet X, Gallego C, Aldea M, et al. 1,25-dihydroxyvitamin D3 regulates VEGF production through a vitamij D response element in the VEGF promoter. Atherosclerosis 2009; 204: 85-89. [DOI:10.1016/j.atherosclerosis.2008.08.020]
24. Robinson CJ, Wagner CL, Hollis BW, Baatz JE, Johnson DD. Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol 2011; 204: 556. e1-4.
25. Maghbooli Z, Hossein-Nezhad A, Shafaei AR, Karimi F, Madani FS, Larijani B. Vitamin D status in mothers and their newborns in Iran. BMC Pregnancy Childbirth 2007; 7: 1. [DOI:10.1186/1471-2393-7-1]
26. Aly YF, El Koumi MA, Abd El Rahman RN. Impact of maternal vitamin D status during pregnancy on the prevalence of neonatal vitamin D deficiency. Pediatr Rep 2013; 5: Ee6. [DOI:10.4081/pr.2013.e6]
27. Hitrova S, Slancheva B, Vakrilova L, Nikolov A, Popivanova A, Yarakova N, et al. Vitamin D levels in maternal-VLBW infants pairs. Akush Ginekol (Sofiia) 2012; 51: 31-38.
28. RK Marya, S Rathee, V Lata, S Mudgil. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981; 12: 155-161. [DOI:10.1159/000299597]
29. Wicherts IS, Boeke AJ, van der Meer IM, van Schoor NM, Knol DL, Lips P. Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: a randomized clinical trial. Osteoporos Int 2011; 22: 873-882. [DOI:10.1007/s00198-010-1343-x]
30. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930. [DOI:10.1210/jc.2011-0385]

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb