جمعه 31 فروردین 1403
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دوره 13، شماره 5 - ( 4-1394 )
جلد 13 شماره 5 صفحات 262-251 |
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Nikuei P, Malekzadeh K, Rajaei M, Nejatizadeh A, Ghasemi N. The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia. IJRM 2015; 13 (5) :251-262
URL: http://ijrm.ir/article-1-652-fa.html
URL: http://ijrm.ir/article-1-652-fa.html
نیکویی پونه، ملک زاده کیانوش، رجایی مینو، نجاتی زاده عظیم، قاسمی نسرین. عدم تعادل دربیان فاکتورهای آنژیوژنیک و آنتی آنژیوژنیک به عنوان بیومارکر جهت پیش آگهی پره اکلامپسی . International Journal of Reproductive BioMedicine. 1394; 13 (5) :251-262
پونه نیکویی1 
، کیانوش ملک زاده* 2، مینو رجایی3 ، عظیم نجاتی زاده1 ، نسرین قاسمی4
، کیانوش ملک زاده* 2، مینو رجایی3 ، عظیم نجاتی زاده1 ، نسرین قاسمی4
1- مرکز تحقیقات پزشکی ملکولی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران
2- مرکز تحقیقات پزشکی ملکولی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران ، keyanoosh@gmail.com
3- مرکز تحقیقات باروری و ناباروری، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران
4- مرکز تحقیقات باروری و ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران
2- مرکز تحقیقات پزشکی ملکولی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران ، keyanoosh@gmail.com
3- مرکز تحقیقات باروری و ناباروری، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران
4- مرکز تحقیقات باروری و ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران
چکیده: (2829 مشاهده)
پره اکلامپسی یک اختلال مهم دوران بارداری با عوارض جدی مادری و جنینی است که اتیولوژی دقیق آن هنوز کاملا مشخص نمی باشد. تشخیص زودرس و درمان به موقع از اهمیت ویژه ای برخوردار بوده و می تواند عوارض بیماری را کاهش دهد.
فاکتور رشد واسکولار اندوتلیالA )VEGF-A( به عنوان یکی از مهم ترین فاکتورهای رشد نقش مهمی در رگ زایی و تکثیر سلولهای اندوتلیال دارد. VEGF و رسپتورهای تیروزین کینازی آن به نامهای Flt-1 و KDR عوامل مهمی در تکامل عروق جفت و جنین هستند. مکانیزم های دخیل در بیان فاکتورهای آنژیوژنیک می توانند منجر به یافتن نکات جدید در پیشگویی و درمان بیماری باشد.
تحقیقات اخیر حاکی از قابلیت استفاده از برخی فاکتورهای آنتی آنژیوژنیک به عنوان بیومارکرهایی جهت پیش آگهی پره اکلامپسی است. sFlt-1 یک واریانت پیرایش شده Flt-1 است که توسط جفت تولید شده و می تواند به فاکتورهای آنژیوژنیک متصل شده و اثر آنها را خنثی کند. همچنین نسبت sFlt-1 به PlGF به عنوان فاکتور پیش آگهی دهنده ارزشمند میباشد. در این مقاله مروری، نقش خانواده VEGF در آنژیوژنز به عنوان بیومارکر در پیش آگهی پره- اکلامپسی مورد مطالعه قرار گرفته است.
فاکتور رشد واسکولار اندوتلیالA )VEGF-A( به عنوان یکی از مهم ترین فاکتورهای رشد نقش مهمی در رگ زایی و تکثیر سلولهای اندوتلیال دارد. VEGF و رسپتورهای تیروزین کینازی آن به نامهای Flt-1 و KDR عوامل مهمی در تکامل عروق جفت و جنین هستند. مکانیزم های دخیل در بیان فاکتورهای آنژیوژنیک می توانند منجر به یافتن نکات جدید در پیشگویی و درمان بیماری باشد.
تحقیقات اخیر حاکی از قابلیت استفاده از برخی فاکتورهای آنتی آنژیوژنیک به عنوان بیومارکرهایی جهت پیش آگهی پره اکلامپسی است. sFlt-1 یک واریانت پیرایش شده Flt-1 است که توسط جفت تولید شده و می تواند به فاکتورهای آنژیوژنیک متصل شده و اثر آنها را خنثی کند. همچنین نسبت sFlt-1 به PlGF به عنوان فاکتور پیش آگهی دهنده ارزشمند میباشد. در این مقاله مروری، نقش خانواده VEGF در آنژیوژنز به عنوان بیومارکر در پیش آگهی پره- اکلامپسی مورد مطالعه قرار گرفته است.
نوع مطالعه: Original Article |
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