دوره 14، شماره 11 - ( 8-1395 )                   جلد 14 شماره 11 صفحات 686-677 | برگشت به فهرست نسخه ها


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Alemu A, Terefe B, Abebe M, Biadgo B. Thyroid hormone dysfunction during pregnancy: A review. IJRM 2016; 14 (11) :677-686
URL: http://ijrm.ir/article-1-709-fa.html
اختلال عملکرد هورمون تیروئید در دوران بارداری: یک مقاله مروری. International Journal of Reproductive BioMedicine. 1395; 14 (11) :677-686

URL: http://ijrm.ir/article-1-709-fa.html


چکیده:   (3797 مشاهده)
اختلالات تیروئید مانند کم­کاری، پرکاری و ندول­های تیروئید ممکن است در دوران بارداری منجر به سقط جنین، جدایی جفت، پره اکلامپسی، زایمان زودرس و عملکرد ذهنی کاهش یافته در فرزندان شود. مطالعات اپیدمیولوژیک نقش مهم هورمون تیروئید مادر در تکوین عصبی جنین و سلامت مادر را نشان داده­اند. اثرات مخرب اختلال عملکرد تیروئید نیز می­تواند فراتر از دوران بارداری و زایمان بوده و بر روی تکوین عصبی ذهنی در اوایل زندگی کودک نیز تاثیر بگذارد. بارداری یک چالش مهم برای غده تیروئید مادر به حساب می­آید به نحوی که هورمون مورد نیاز در طول بارداری به دنبال افزایش در اتصال تیروئید-گلوبولین ، اثر تحریکی هورمون hCG بر گیرنده TSH و افزایش نیاز محیطی به هورمون تیروئید، افزایش می­یابد. اختلال عملکرد تیروئید مادر با افزایش خطر ابتلا به سقط زودرس، زایمان زودرس و بیماری نوزادان همراه است. تشخیص زود هنگام برای اختلال عملکرد تیروئید در زنان باردار و درمان اختلال عملکرد تیروئید در دوران بارداری برای جلوگیری از عوارض مادری و جنینی ثانویه به اختلال عملکرد تیروئید مهم و مقرون به صرفه است. بنابراین هدف از این بررسی ارزیابی تغییرات عملکرد تیروئید در دوران بارداری، اختلالات مختلف در ارتباط با مادر و پیامدهای جنین و شیوه­های تشخیص آزمایشگاهی در این زمینه، و بهترین راه برای مدیریت این شرایط بود.
نوع مطالعه: Original Article |

فهرست منابع
1. De Escobar GM, Obregón MJ, del Rey FE. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract Res Clin Endocrinol Metab 2004; 18: 225-248. [DOI:10.1016/j.beem.2004.03.012]
2. Kilby MD. Thyroid hormones and fetal brain development. Clin Endocrinol 2003; 59: 280-281. [DOI:10.1046/j.1365-2265.2003.01804.x]
3. Brent GA. The debate over thyroid-function screening in pregnancy. New Eng J Med 2012; 366: 562-563. [DOI:10.1056/NEJMe1112591]
4. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 18; 404: 1997. [DOI:10.1210/edrv.18.3.0300]
5. Haddow JE,Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New Eng J Med 1999; 341: 549-555. [DOI:10.1056/NEJM199908193410801]
6. Skjoldebrand L, Brundin J, Carlstrom A, Pettersson T. Thyroid associated components in serum during normal pregnancy. Acta Endocrinol 1982; 100: 504-511. [DOI:10.1530/acta.0.1000504]
7. Casey B, Leveno K. Thyroid disease in pregnancy. Obstet Gynecol 2006; 108: 1283-1292. [DOI:10.1097/01.AOG.0000244103.91597.c5]
8. Okosieme OE, Marx H, Lazarus JH. Medical management of thyroid dysfunction in pregnancy and the postpartum. Expert Opin Pharmacother 2008; 9: 2281-2293. [DOI:10.1517/14656566.9.13.2281]
9. Berghout A, Wiersinga W. Thyroid size and thyroid function during pregnancy. An analysis. Eur J Endocrinol 1998; 138: 536-542. [DOI:10.1530/eje.0.1380536]
10. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J,, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New Eng J Med 1999; 341: 549-555. [DOI:10.1056/NEJM199908193410801]
11. Cooper D.S. Hyperthyroidism. Lancet 2003; 362: 459-468. [DOI:10.1016/S0140-6736(03)14073-1]
12. Marx H, Amin P, Lazarus JH. Hyperthyroidism and pregnancy. BMJ 2008; 336: 663-667. [DOI:10.1136/bmj.39462.709005.AE]
13. Wang W, Teng W, Shan Z, Wang S, Li J, Zhu L, et al. The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy. Eur J Endocrinol 2011; 164: 263-268. [DOI:10.1530/EJE-10-0660]
14. DeRuiter J. Thyroid hormone tutorial: thyroid pathology. Endocrine Module (PYPP 5260), Thyroid Section, spring. Available at: http://www.book.xlibx. info/bo-other/3556700-1-endocrine-module-pypp-526 0-thyroid-section-spring-2002-thyroid-h.php.
15. Bishnoi A, Sachmechi I. Thyroid disease in pregnancy. Am Fam Physic 1996; 53: 215-220.
16. Trivalle C, Doucet J, Chassagne P, Landrin I, Kadri N, Menard JF, et al. Differences in the signs and symptoms of hyperthyroidism in older and younger patients. J Am Geriatr Soc 1996; 44: 50-53. [DOI:10.1111/j.1532-5415.1996.tb05637.x]
17. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001; 344: 501-509. [DOI:10.1056/NEJM200102153440707]
18. Karnath BM, Beary WM, Ahmad M, McKinney KH. Thyrotoxicosis presenting as pulmonary hypertension. J Respir Dis 2004; 25: 387-389.
19. Marvisi M, Brianti M, Marani G, Del Borello R, Bortesi ML, Guariglia A. Hypothyroidism and pulmonary hypertension. Respire Med 2002; 96: 215-220 [DOI:10.1053/rmed.2001.1260]
20. Glinoer D. Thyroid Hyper function during pregnancy. Thyroid 1998; 8: 859-864. [DOI:10.1089/thy.1998.8.859]
21. Fitzgerald PA. Endocrinology. In: Tierny LM, McPhee SJ, Papadakis MA. Current medical diagnosis and treatment. 44PthP Ed. New York: McGraw-Hill; 2005: 1102-1110.
22. Patil-Sisodia K, Mestman JH. "Graves hyperthyroidism and pregnancy: a clinical update," Endocrine Pract 2010; 16: 118-129, [DOI:10.4158/EP09233.RA]
23. Greenwood RM, Daly JG, Himsworth RL. Hyperthyroidism and the impalpable thyroid gland. Clin Endocrinol (Oxf) 1985; 22: 583-587. [DOI:10.1111/j.1365-2265.1985.tb02993.x]
24. Lazarus JH. Thyroid disorders associated with pregnancy: etiology, diagnosis, and management. Treat Endocrinol 2005; 4: 31-41. [DOI:10.2165/00024677-200504010-00004]
25. Ogunyemi DA. Autoimmune thyroid disease and pregnancy. eMedicine website. Available at: www. emedicine. medscape.com/article/261913-overview. Updated April 23, 2010.
26. Komal PS, Mestman JH. Graves's hyperthyroidism and pregnancy: a clinical update. Endocrine Pract 2010; 16: 118-129. [DOI:10.4158/EP09233.RA]
27. Carranza-Lira S, Hernandez F, Sanchez M, Murrieta S, Hernandez A, Sandoval C. Prolactin secretion in molar and normal pregnancy. Int J Gynecol Obstet 1998; 60: 137-141. [DOI:10.1016/S0020-7292(97)00251-8]
28. Hershman JM. Trophoblastic tumors. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid: a fundamental and clinical text. Philadelphia, PA: JP Lippincott; 1991: 705-709.
29. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997; 18: 404-433. [DOI:10.1210/edrv.18.3.0300]
30. Goodwin TM, Hershman JM. Hyperthyroidism due to inappropriate production of human chorionic gonadotropin. Clin Obstet Gynecol 1997; 40: 32-44. [DOI:10.1097/00003081-199703000-00006]
31. Kimura M, Amino M, Tamaki H, Ito E, Mitsuda N, Miyai K, et al. Gestational thyrotoxicosis and hyperemesis gravidarum: Possible role of hCG with higher stimulating activity. Clin Endocrinol 1993; 38: 345-350. [DOI:10.1111/j.1365-2265.1993.tb00512.x]
32. Tan JY, Loh KC, Yeo GS, Chee YC. Transient hyperthyroidism of hyperemesis gravidarum. BJOG 2002; 109: 683-688. [DOI:10.1111/j.1471-0528.2002.01223.x]
33. Goodwin TM, Montoro M, Mestman JH. Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. Am J Obstet Gynecol 1992; 167: 648-652. [DOI:10.1016/S0002-9378(11)91565-8]
34. Goodwin TM, Montoro M, Mestman JH, Pekary AE, Hershman JM. The role of chorionic gonadotropin in transient hyperthyroidism of hyperemesis gravidarum. J Clin Endocrinol Metab 1992; 75: 1333-1337.
35. Casey BM, Dashe JS, Wells CE, Mclntier DD, Leveno KJ, Cuningham FG, et al. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol 2006; 107: 337-341. [DOI:10.1097/01.AOG.0000197991.64246.9a]
36. Glinoer D, De Nayer P, Robyn C, Lejeune B, Kinthaert J, Meuris S. Serum levels of intact HCG and its free a and ß subunits, in relation to maternal thyroid stimulation during normal pregnancy. Eur J Endocrinol Invest 1993; 16: 881-888. [DOI:10.1007/BF03348950]
37. Yoshimura M, Hershman JM. Thyrotropic action of HCG. Thyroid 1995; 5: 4254-4234. [DOI:10.1089/thy.1995.5.425]
38. Corvilain B, Dumont JF, Vassart G. Toxic adenoma and toxic multinodular goiter. In: Werner SC, Ingbar SH, Braverman LE, Utiger RD. eds. Werner, Ingbar's the thyroid: a fundamental and clinical text. 8th Ed. Philadelphia: Lippincott Williams & Wilkins; 2000: 564-572.
39. Slatosky J, Shipton B, Wahba H. Thyroiditis: differential diagnosis and management. Am Fam Physician 2000; 61: 1047-1052.
40. Ross D. Medical diseases in women. In: Carlson KJ, Eisenstat SA. eds. Primary care of women. 2nd Ed. St. Louis, Mosby; 2002.
41. Burrow GN. Thyroid function and hyperfunction during gestation. Endocr Rev 1993; 14:194-202. [DOI:10.1210/edrv-14-2-194]
42. Hollingsworth DR. Hyperthyroidism in pregnancy. In: Ingban SH, Braverman LE, eds. 5th Ed. Werner's The Thyroid. A Fundamental and Clinical Text. Philadelphia, JB Lippincott; 1986: 1043-1063.
43. Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid 1999; 9: 727-733. [DOI:10.1089/thy.1999.9.727]
44. Polak M, Le Gac I, Vuillard E, Guibourdenche J, Leger J, Toubert ME, et al. Fetal and neonatal thyroid function in relation to maternal Graves' disease. Best Pract Res Clin Endocrinol Metab 2004; 18: 289-302. [DOI:10.1016/j.beem.2004.03.009]
45. Kung AW, Low L. Thyrotropin blocking antibodies in congenital hypothyroidism. J Paediatr Child Health 1992; 28: 50-53. [DOI:10.1111/j.1440-1754.1992.tb02617.x]
46. Lin SH. Thyrotoxic periodic paralysis. Mayo Clin Proc 2005; 80: 99-105. [DOI:10.1016/S0025-6196(11)62965-0]
47. American Academy of Clinical Endocrinologists. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract 2002; 8: 457-469. [DOI:10.4158/1934-2403-8.6.457]
48. Harper MB, Mayeaux EJ. Thyroid disease. In: Taylor R.B. Family medicine: principles and practice. 6th Ed. New York, Springer; 2003: 1042-1052. [DOI:10.1007/978-0-387-21744-4_121]
49. Taylor R.B. The 10-minute diagnosis manual: symptoms and signs in the time-limited encounter. Philadelphia, Lippincott Williams & Wilkins; 2000.
50. Mestman JH. Hyperthyroidism in pregnancy. Clin Obstet Gynecol 1997; 40: 45-64. [DOI:10.1097/00003081-199703000-00007]
51. Hershman JM. Hyperthyroidism induced by trophoblastic thyrotropin. Mayo Clin Proc 1972; 47: 913-918.
52. Roberts CG, Ladenson PW. Hypothyroidism. Lancet 2004; 363: 793-803. [DOI:10.1016/S0140-6736(04)15696-1]
53. Klein RZ, Haddow JE, Faix JD, Brown RS, Hermos RJ, Pulkkinen A, et al. Prevalence of thyroid deficiency in pregnant women. Clin Endocrinol 1991; 35: 41-46. [DOI:10.1111/j.1365-2265.1991.tb03494.x]
54. Mandel SJ. Hypothyroidism and chronic autoimmune thyroiditis in the pregnant state: maternal aspects. Best Pract Res Clin Endocrinol Metab 2004; 18: 213-224. [DOI:10.1016/j.beem.2004.03.006]
55. Indra R, Patil SS, Joshi R, Pai M, Kalantri SP. Accuracy of physical examination in the diagnosis of hypothyroidism: a cross sectional, double-blind study. J Postgrad Med 2004; 50: 7-11.
56. Alkafajei A, Amarin Z, Alazaizeh W, Khader Y, Marji M. Prevalence and risk factors for hypothyroidism in Jordanian women: comparison between different reference ranges. East Med Health J 2012; 18: 2. [DOI:10.26719/2012.18.2.132]
57. Lafranchi SH, Haddow JE, Hollowell JG. Is thyroid inadequacy during gestation a risk factor for adverse pregnancy and developmental outcomes? Thyroid 2005; 15: 60-71. [DOI:10.1089/thy.2005.15.60]
58. Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A, Levalle O. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 2002; 12: 63-68. [DOI:10.1089/105072502753451986]
59. Roneé EW, Hamisu MS, Maureen WG, Dagne G, O'Rourke K, Alfred KM. Impact of Maternal Thyroperoxidase Status on Fetal Body and Brain Size. Thyroid 2003; 3: 340-56.
60. Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy. Hum Reprod Update 2003:9: 149-161. [DOI:10.1093/humupd/dmg012]
61. Glinoer D, Riahi M, Grun JP, Kinthaert J. Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab 1994; 79: 197-204.
62. Cleary-Goldman J, Malone FD, Lambert-Messerlian G, Sullivan L, Canick J, Porter TF, et al. Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynecol 2008; 112: 85-92. [DOI:10.1097/AOG.0b013e3181788dd7]
63. Salvi M, How J. Pregnancy and autoimmune thyroid disease. Endocrinol Metab Clin North Am 1987; 16: 431-444.
64. Muller AF, Drexhage HA, Berghout A. Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. Endocrine Rev 2001; 22: 605-630. [DOI:10.1210/edrv.22.5.0441]
65. Obregon MJ, Escobar del Rey F, Morreale de Escobar G. The effects of iodine deficiency on thyroid hormone deiodination. Thyroid 2005; 15: 917-929. [DOI:10.1089/thy.2005.15.917]
66. Mezosi E, Molnar I, Jakab A, Balogh E, Karanyi Z, Pakozdy Z, et al. Prevalence of iodine deficiency and goitre during pregnancy in east Hungary. Eur J Endocrinol 2000; 143: 479-483. [DOI:10.1530/eje.0.1430479]
67. Raymond J, Lafranchi SH. Fetal and neonatal thyroid function: review and summary of significant new findings. Curr Opin Endocrinol Diabetes Obes 2010; 17: 1-7. [DOI:10.1097/MED.0b013e328333b0b2]
68. Casey BM, Dashe JS, Edward Wells C, McIntire DD, Byrd W, Leveno KJ, et al. Subclinical hypothyroidism and pregnancy outcomes. Am Col Obstet Gynecol 2005; 105: 239-245. [DOI:10.1097/01.AOG.0000152345.99421.22]
69. Haddow JE, Palomaki GE, All an WC, Williams JR, Knight GJ, Gagnon J, et al. Maternal thyroid deficincy during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999; 341: 549-555. [DOI:10.1056/NEJM199908193410801]
70. Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol 2003; 59: 228-288. [DOI:10.1046/j.1365-2265.2003.01822.x]
71. Kooistra L, Crawford S, van Baar AL, Brouwers EP, Pop VJ. Neonatal effects of maternal hypothyroxinemia during early pregnancy. J Am Acad Pediatrics 2006: 117; 161-167. [DOI:10.1542/peds.2005-0227]
72. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2007; 92: S1-47. [DOI:10.1210/jc.2007-0141]
73. Velkeniers B, Van Meerhaeghe A, Poppe K, Unuane D, Tournaye H, Haentjens P. Levothyroxine treatment and pregnancy outcome in women with subclinical hypothyroidism undergoing assisted reproduction technologies: systematic review and meta-analysis of RCTs. Hum Reprod Update 2013; 19: 251-258. [DOI:10.1093/humupd/dms052]
74. Zimmerman MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr 2009; 89: 668S-672S. [DOI:10.3945/ajcn.2008.26811C]
75. Murcia M, Rebagliato M, Iniguez C, Lopez-Espinosa M, Estarlich M, Plaza B, et al. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 Year of Age. Am J Epidemiol 2011; 173: 804-812. [DOI:10.1093/aje/kwq424]

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