Volume 14, Issue 3 (3-2016)                   IJRM 2016, 14(3): 193-198 | Back to browse issues page

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Mahran A, Ibrahim M, Bahaa H. The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial. IJRM 2016; 14 (3) :193-198
URL: http://ijrm.ir/article-1-733-en.html
The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial
Ahmad Mahran * 1, Mahmoud Ibrahim2 , Haitham Bahaa2
1- Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt , ezzeldin_ahmad@yahoo.com
2- Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt
Abstract:   (4280 Views)
Background: Implantation remains a limiting step in IVF/ICSI. Endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after IVF/ICSI.
Objective: The aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on IVF/ICSI outcome.
Materials and Methods: Four hundred patients undergoing their first IVF/ICSI cycle in two IVF units in Minia, Egypt were randomly selected to undergo either endometrial injury in luteal phase of preceding cycle (intervention group) or no treatment (control group). Primary outcome wasthe implantation and live birth ratesWhile the  secondary outcome was clinical pregnancy, miscarriage, multiple pregnancy rates, pain and bleeding during and after procedure.
Results: Implantation and live birth rates were significantly higher in intervention compared with control group (22.4% vs. 18.7%, p=0.02 and 67% vs. 28%, p=0.03), respectively. There was also a significant reduction in miscarriage rate in intervention group (4.8% vs. 19.7%, respectively, p<0.001).
Conclusion: Endometrial injury in preceding cycle improves the implantation rate and live birth rate and reduces the miscarriage rate per clinical pregnancy in patients undergoing their first IVF/ICSI cycle.
Keywords: Endometrial injury, Implantation rate, Live birth rate, In vitro fertilization (IVF), Intra cytoplasmic sperm injection (ICSI).
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Type of Study: Original Article |
References
1. Li R, Hao G. Local injury to the endometrium: its effect on implantation. Cur Opin Obstet Gynecol 2009; 21: 236-239. [DOI:10.1097/GCO.0b013e32832a0654]
2. Haider S, Knöfler M. Human tumor necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30: 111-123. [DOI:10.1016/j.placenta.2008.10.012]
3. Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94: 2030-2036. [DOI:10.1016/j.fertnstert.2010.02.022]
4. Veeck L. The morphological assessment of human oocytes and early conception. In Keel BA, Webster BW, editors. Handbook of the laboratory diagnosis and treatment of infertility. Boca Raton FL; CRC Press. 1990: 353-369.
5. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology. Hum Reprod 2009; 24: 2683-2687. [DOI:10.1093/humrep/dep343]
6. Kumbak B, Shahin L, Ozkan S, Atilgan R. Impact of luteal phase hysteroscopy and concurrent endometrial biopsy on subsequent IVF cycle outcome. Arch Gynecol Obstet 2014; 290: 269-274. [DOI:10.1007/s00404-014-3211-y]
7. Karmizade MA, Oskouian H, Ahmadi S, Oskouian L. Local injury to the endometrium on the day of oocyte retrieval has a negative impact on implantation in assisted reproductive cycles: a randomized controlled trial. Arch Gynaecol Obstet 2010; 281: 499-503. [DOI:10.1007/s00404-009-1166-1]
8. Barash A, Dekel N, Fieldust S, Segal I, Schectman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril 2003; 79: 1317-1322. [DOI:10.1016/S0015-0282(03)00345-5]
9. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49: 677-680. [DOI:10.1111/j.1479-828X.2009.01076.x]
10. Narvekar SA, Gupta N, Shetty N, Kottur A, Srinivas M, Rao KA. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study. J Hum Reprod Sci 2010; 3: 15-19. [DOI:10.4103/0974-1208.63116]
11. Shohayeb A, El-Khyat W. Does a single endometrial biopsy regimen (S-EBR) improve outcome in patients with repeated implantation failure? A randomized controlled trial. Eur J Obstet Gynecol Reprod Biol 2012; 164: 176-179. [DOI:10.1016/j.ejogrb.2012.06.029]
12. El-Toukhy TA, Sunkara SK, Khalaf Y. Endometrial injury and outcome of the subsequent IVF cycle. A systematic review and meta-analysis. Fertil Steril 2001; 96 (Suppl.): S277. [DOI:10.1016/j.fertnstert.2011.07.1057]
13. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure; a systematic review and meta-analysis. Reprod BioMed Online 2012; 25: 561-571. [DOI:10.1016/j.rbmo.2012.08.005]
14. Nastri CO, Gibreel A, Raine-Fenning N, Maheshwari A, Ferriani RA, Bhattacharya S, Martins WP. Endometrial injurt in women undergoing assited reproductive technology (Review). The Cochrane Collaboration. The Cochrane Library 2012, Issue 7.
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