Volume 15, Issue 12 (12-2017)
IJRM 2017, 15(12): 757-762 |
Back to browse issues page
Marzieh Aghahosseini1 
, Ashraf Aleyasin1 , Fatemeh Sadat Sarfjoo1 , Atossa Mahdavi * 2, Mansooreh Yaraghi3 , Hojattollah Saeedabadi4
, Ashraf Aleyasin1 , Fatemeh Sadat Sarfjoo1 , Atossa Mahdavi * 2, Mansooreh Yaraghi3 , Hojattollah Saeedabadi4
1- Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran , sarfjoo.mona@gmail.com
3- Department of Obstetrics, Gynecology and Pelvic Floor Disorders, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Embryology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran , sarfjoo.mona@gmail.com
3- Department of Obstetrics, Gynecology and Pelvic Floor Disorders, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Embryology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abstract: (2747 Views)
Background: The effect of elevated progesterone level on human chorionic gonadotropin (HCG) day in in vitro fertilization cycles is controversial. Some suppose that rise in progesterone level seems to have a negative impact on implantation and pregnancy by desynchronizing the endometrium, while others disagree.
Objective: To evaluate the superiority of the frozen cycle over fresh cycle on live birth in patients with elevated progesterone level on HCG day.
Materials and Methods: In this double-blind, randomized clinical trial, 72 women undergoing assisted reproductive technology with elevated progesterone level (≥1.8 ng/dl) on HCG day were included. The participants were grouped by fresh versus frozen embryo transfer, randomly. Finally, the clinical pregnancy and live birth rate were compared.
Results: The implantation rate was 21.51%. The clinical pregnancy rate was 47.22% in fresh embryo transfer group (17/36) and 41.66% in frozen group (15/36) (p=0. 40). The live birth rate was not significantly difference between two groups (p=0.56).
Conclusion: None of the fresh and frozen cycles are superior to the other and we recommend individualizing the decision for each patient. The frozen cycle may impose more emotional stress on patients
Objective: To evaluate the superiority of the frozen cycle over fresh cycle on live birth in patients with elevated progesterone level on HCG day.
Materials and Methods: In this double-blind, randomized clinical trial, 72 women undergoing assisted reproductive technology with elevated progesterone level (≥1.8 ng/dl) on HCG day were included. The participants were grouped by fresh versus frozen embryo transfer, randomly. Finally, the clinical pregnancy and live birth rate were compared.
Results: The implantation rate was 21.51%. The clinical pregnancy rate was 47.22% in fresh embryo transfer group (17/36) and 41.66% in frozen group (15/36) (p=0. 40). The live birth rate was not significantly difference between two groups (p=0.56).
Conclusion: None of the fresh and frozen cycles are superior to the other and we recommend individualizing the decision for each patient. The frozen cycle may impose more emotional stress on patients
Type of Study: Original Article |
References
1. De Ziegler D, Bijaoui G, Chapron C. Pre-hCG elevation of plasma progesterone: good, bad or otherwise. Hum Reprod Update 2008; 14: 393. [DOI:10.1093/humupd/dmn020]
2. Hill MJ, Royster GD, Healy MW, Richter KS, Levy G, DeCherney AH, et al. Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation? Fertil Steril 2015; 103: 1477-1484. [DOI:10.1016/j.fertnstert.2015.02.038]
3. Xu B, Li Z, Zhang H, Jin L, Li Y, Ai J, Zhu G. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Steril 2012; 97: 1321-1327. [DOI:10.1016/j.fertnstert.2012.03.014]
4. Al-Azemi M, Kyrou D, Kolibianakis EM, Humaidan P, Van Vaerenbergh I, Devroey P, et al. Elevated progesterone during ovarian stimulation for IVF. Reprod Biomed Online 2012; 24: 381-388. [DOI:10.1016/j.rbmo.2012.01.010]
5. Martinez F, Rodriguez I, Devesa M, Buxaderas R, Gómez MJ, Coroleu B. Should progesterone on the human chorionic gonadotropin day still be measured? Fertil Steril 2016; 105: 86-92. [DOI:10.1016/j.fertnstert.2015.09.008]
6. Tsai YR, Huang FJ, Lin PY, Kung FT, Lin YJ, Lin YC, et al. Progesterone elevation on the day of human chorionic gonadotropin administration is not the only factor determining outcomes of in vitro fertilization. Fertil Steril 2015; 103: 106-111. [DOI:10.1016/j.fertnstert.2014.10.019]
7. Santos-Ribeiro S, Polyzos NP, Haentjens P, Smitz J, Camus M, Tournaye H, et al. Live birth rates after IVF are reduced by both low and high progesterone levels on the day of human chorionic gonadotropin administration. Hum Reprod 2014; 29: 1698-1705. [DOI:10.1093/humrep/deu151]
8. Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update 2013; 19: 433-457. [DOI:10.1093/humupd/dmt014]
9. Healy MW, Patounakis G, Connell M, Devine K, DeCherney AH, Levy MJ, et al. Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles? Fertil Steril 2016; 105: 93-99. [DOI:10.1016/j.fertnstert.2015.09.015]
10. Singh N, Malik N, Malhotra N, Vanamail P, Gupta M. Impact of Progesterone (On hCG Day)/Oocyte Ratio on Pregnancy Outcome in Long Agonist Non Donor Fresh IVF/ICSI Cycles. Taiwan J Obstet Gynecol 2016; 55: 503-506. [DOI:10.1016/j.tjog.2015.09.005]
11. Park JH, Jee BC, Kim SH. Factors influencing serum progesterone level on triggering day in stimulated in vitro fertilization cycles. Clin Exp Reprod Med 2015; 42: 67-71. [DOI:10.5653/cerm.2015.42.2.67]
12. Shalom-Paz E, Aslih N, Samara N, Michaeli M, Ellenbogen A. Late follicular progesterone to estradiolratio is not influenced by protocols oR gonadotropins used. Reprod Biol Endocrinol 2015; 13: 119. [DOI:10.1186/s12958-015-0116-y]
13. Ghaseminejad A, Rezaee Z, Forootan M, Hosseinipoor T, Forghani F, Nikuei P. Effect of predictive value of progesterone level on the day of HCG injection for IVF success in women with infertility due to tubal factor or polycystic ovarian syndrome referred to the women hospital, Tehran, 2009. Iran J of Reprod Med 2012; 10: 349-354.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |