International Journal of
Reproductive Biomedicine
Sun, Apr 6, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 320-320 |
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Taheri F, Khalili MA, Aflatoonian A, Kalantar SM, Kariminejad R, Moshrefi M. P-153 Cytogenetic study of poor quality embryos not transferred in in vitro fertilization compared with control group. IJRM 2021; 19 (5) :320-320
URL: http://ijrm.ir/article-1-2994-en.html
URL: http://ijrm.ir/article-1-2994-en.html
1- Department of Reproductive Biology, Yazd Institute for Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , taherifatemeh86@yahoo.com
2- Department of Reproductive Biology, Yazd Institute for Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Abortion Research Center, Yazd Institute for Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- Kariminejad-Najmabadi Pathology and Genetics Center, Tehran, Iran.
5- Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institue, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Department of Reproductive Biology, Yazd Institute for Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Abortion Research Center, Yazd Institute for Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- Kariminejad-Najmabadi Pathology and Genetics Center, Tehran, Iran.
5- Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institue, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (216 Views)
Background: An association between morphology, and genetic integrity in human embryos is stablished, but this relationship is not absolute.
Objective: This study investigated the correlation between embryo morphological characteristics and chromosomal status in biopsied human embryos, using the array comparative genomic hybridization technique.
Materials and Methods: Preimplantation genetic testing for aneuploidy was performed on Day 3 embryos (n = 120) divided into two groups: 60 ‘deselected’ embryos (unsuitable for transfer or vitrification) versus 60 ‘selected’ embryos (suitable for transfer or vitrification). The morphological grading criteria, including blastomere number, symmetry, percentage of fragmentation rate, and zona pellucida appearance were correlated with array comparative genomic hybridization results.
Results: The incidence of chromosomal abnormalities was significantly higher in embryos with uneven blastomeres, fragmentations, and thick zona pellucida appearance.
Conclusion: In general, embryo selection based of morphological assessment cannot confirm the chromosomal integrity. However, some morphological parameters reflect the cytogenetic status of the deselected embryos.
Objective: This study investigated the correlation between embryo morphological characteristics and chromosomal status in biopsied human embryos, using the array comparative genomic hybridization technique.
Materials and Methods: Preimplantation genetic testing for aneuploidy was performed on Day 3 embryos (n = 120) divided into two groups: 60 ‘deselected’ embryos (unsuitable for transfer or vitrification) versus 60 ‘selected’ embryos (suitable for transfer or vitrification). The morphological grading criteria, including blastomere number, symmetry, percentage of fragmentation rate, and zona pellucida appearance were correlated with array comparative genomic hybridization results.
Results: The incidence of chromosomal abnormalities was significantly higher in embryos with uneven blastomeres, fragmentations, and thick zona pellucida appearance.
Conclusion: In general, embryo selection based of morphological assessment cannot confirm the chromosomal integrity. However, some morphological parameters reflect the cytogenetic status of the deselected embryos.
Type of Study: Congress Abstract |
Subject:
Fertility & Infertility
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