International Journal of
Reproductive Biomedicine
Wed, Apr 2, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 330-330 |
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Dehestani M, Montazeri F, Nikounahad N. P-163 Polymorphism of ESRI (XbaIG/A) as a genetic agent in women with poor response to controlled ovarian hyperstimulation. IJRM 2021; 19 (5) :330-330
URL: http://ijrm.ir/article-1-3008-en.html
URL: http://ijrm.ir/article-1-3008-en.html
1- Biology Department, Faculty of Sciences, Science and Art University, Yazd, Iran. , mansooreh_db1370@yahoo.com
2- Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Biology Department, Faculty of Sciences, Science and Art University, Yazd, Iran.
2- Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Biology Department, Faculty of Sciences, Science and Art University, Yazd, Iran.
Abstract: (239 Views)
Background: Physiological function of ovarian regulates by reproductive hormones including estrogen. Estrogen is a steroidal hormone and its actions in ovary mostly occur through its binding to intracellular receptor α and β. ESR1 (α) gene include many polymorphic sites (SNPs) located along various regions of it that control expression and function of this receptor.
Objective: This paper aimed to investigate the association of XbaI A/G (rs9340799) with poor ovarian response in Iranian women undergoing IVF treatment referred to Yazd Reproductive Sciencse Institute.
Materials and Methods: To do so, a group of 40 women with normal response ovarian and a group of 209 women with poor response ovarian in IVF cycles were included. Genomic DNA extraction was performed with Blood DNA Extraction Kit (Favorgen Co.). Using PCR-FRLP technique and XbaI restriction enzyme SNP in -29 G/A site of ESR1 gene were genotyped.
Results: Our finding show polymorphisms in ESR1 (rs9340799) was significantly different between women with normal and poor response ovary considering AG+GG and GG+AA (p = 0.005) genotype but was not statisticaly signification regarding to AA+AG (p ≤ 0.05).
Conclusion: The study of SNPs of the ESR1 gene is an interesting field of research that could provide us with new facts considering the way each woman responds to standard stimulation protocol in IVF cycle.
Objective: This paper aimed to investigate the association of XbaI A/G (rs9340799) with poor ovarian response in Iranian women undergoing IVF treatment referred to Yazd Reproductive Sciencse Institute.
Materials and Methods: To do so, a group of 40 women with normal response ovarian and a group of 209 women with poor response ovarian in IVF cycles were included. Genomic DNA extraction was performed with Blood DNA Extraction Kit (Favorgen Co.). Using PCR-FRLP technique and XbaI restriction enzyme SNP in -29 G/A site of ESR1 gene were genotyped.
Results: Our finding show polymorphisms in ESR1 (rs9340799) was significantly different between women with normal and poor response ovary considering AG+GG and GG+AA (p = 0.005) genotype but was not statisticaly signification regarding to AA+AG (p ≤ 0.05).
Conclusion: The study of SNPs of the ESR1 gene is an interesting field of research that could provide us with new facts considering the way each woman responds to standard stimulation protocol in IVF cycle.
Keywords: Alpha-estrogen receptor, Polymorphism -29 G>A (rs9340799), Poor ovarian resesponse, RFLP-PCR.
Type of Study: Congress Abstract |
Subject:
Fertility & Infertility
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