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Thu, Apr 17, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 295-295 |
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Namavar Jahromi B, Zeyghami Sh, Parsanezhad ME, Ghaemmaghami P, Zarei A, Azizi Kutenaee M, et al . P-128 Determining an optimal cut-off value for follicle-stimulating hormone to predict microsurgical testicular sperm extraction outcome in patients with non-obstructive azoospermia. IJRM 2021; 19 (5) :295-295
URL: http://ijrm.ir/article-1-3038-en.html
URL: http://ijrm.ir/article-1-3038-en.html
Namavar Jahromi B * 
1, Zeyghami Sh2 , Parsanezhad ME3 , Ghaemmaghami P4 , Zarei A3 , Azizi Kutenaee M5 , Sohail P4 , Keshavarz P6
1, Zeyghami Sh2 , Parsanezhad ME3 , Ghaemmaghami P4 , Zarei A3 , Azizi Kutenaee M5 , Sohail P4 , Keshavarz P6
1- Infertility Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran. , namavarb@sums.ac.ir
2- Ghadir Madar Hospital, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Infertility Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Biostatistics, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Ghadir Madar Hospital, Hormozgan Fertility and Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
6- Department of Radiology, Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Ghadir Madar Hospital, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Infertility Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Biostatistics, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Ghadir Madar Hospital, Hormozgan Fertility and Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
6- Department of Radiology, Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract: (226 Views)
Background: Determining the success of sperm retrieval for infertile men before using assisted reproductive technologies can decrease the costs. Using endocrine markers, as an inexpensive and non-invasive method is considered to be a clinically suitable marker in assessment of infertile men.
Objective: To determine the optimal cut-off value for follicle stimulating hormone (FSH) to predict the outcome of microsurgical testicular sperm extraction (micro-TESE) in patients with nonobstructive azoospermia (NOA).
Materials and Methods: We included a total number of 180 patients with NOA. The serum level of FSH was determined and all the subjects underwent micro-TESE. We determined the optimal cut-off value for FSH and assessed whether the test could be effectively used as a successful predictor of sperm retrieval by calculating the receiver operating characteristic area under the curve.
Results: Overall, we included a total number of 171 patients with mean age of 34.3 ± 8.6 yr. The micro-TESE was considered to be successful in 79 (43.8%) while it failed in 92 (56.2%) patients. We found that the mean level of serum FSH was significantly higher in group those with failed micro-TEST compared to successful group (P < 0.001). The cut-off value for FSH was calculated to be 14.6 mIU/mL to predictive the outcome of micro-TESE with a sensitivity of 83.5% [73.5%-90.9%] and a specificity of 80.3% [69.5%-88.5%]. At this value, the other parameters were calculated to be PPV, 81.5%; NPV, 82.4; LR+, 4.23; and LR-, 0.21.
Conclusion: The results of the current study indicate that FSH plasma levels above 14.6 mIU/mL can be considered to be the failure predictor of the micro-TESE in NOA patients.
Objective: To determine the optimal cut-off value for follicle stimulating hormone (FSH) to predict the outcome of microsurgical testicular sperm extraction (micro-TESE) in patients with nonobstructive azoospermia (NOA).
Materials and Methods: We included a total number of 180 patients with NOA. The serum level of FSH was determined and all the subjects underwent micro-TESE. We determined the optimal cut-off value for FSH and assessed whether the test could be effectively used as a successful predictor of sperm retrieval by calculating the receiver operating characteristic area under the curve.
Results: Overall, we included a total number of 171 patients with mean age of 34.3 ± 8.6 yr. The micro-TESE was considered to be successful in 79 (43.8%) while it failed in 92 (56.2%) patients. We found that the mean level of serum FSH was significantly higher in group those with failed micro-TEST compared to successful group (P < 0.001). The cut-off value for FSH was calculated to be 14.6 mIU/mL to predictive the outcome of micro-TESE with a sensitivity of 83.5% [73.5%-90.9%] and a specificity of 80.3% [69.5%-88.5%]. At this value, the other parameters were calculated to be PPV, 81.5%; NPV, 82.4; LR+, 4.23; and LR-, 0.21.
Conclusion: The results of the current study indicate that FSH plasma levels above 14.6 mIU/mL can be considered to be the failure predictor of the micro-TESE in NOA patients.
Keywords: Follicle-stimulating hormone, Non-obstructive azoospermia, Microsurgical testicular sperm extraction.
Type of Study: Congress Abstract |
Subject:
Perinatology
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