International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1403
7
1
gregorian
2024
10
1
22
10
online
1
fulltext
en
ارتباط بین اختلالات قاعدگی، آنتیمولرین هورمون و کووید-19: یک مطالعه کوهورت آیندهنگر
Association between menstrual disorders and anti-Müllerian hormone with COVID-19: A prospective cohort study
Reproductive Endocrinology
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">کروناویروس 2019 (کووید-19) تقریباً تمام جوامع را در سراسر جهان تحت تأثیر قرار داده است.</span></span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">سیستم­های مختلف بدن را تحت تأثیر قرار می­دهد که عواقب جبران­ناپذیری به همراه دارد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این مطالعه با هدف بررسی تأثیر ویروس کووید-19 بر اختلالات قاعدگی، آنتی­مولرین هورمون (</span></span><span dir="LTR" style="font-size:10.0pt">AMH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">)، تیروئید پراکسیداز (</span></span><span dir="LTR" style="font-size:10.0pt">TPO</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">)، هورمون محرک تیروئید (</span></span><span dir="LTR" style="font-size:10.0pt">TSH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) و سطح پرولاکتین در زنان مبتلا به بیماری کووید-19 انجام شد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مواد و روش ­ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این مطالعه کوهورت آیندهنگر بر روی 201 زن (101 زن سالم و 100 زن مبتلا به کووید-19) در بیمارستان عشایری خرمآباد از بهمن 1399 تا مهر 1400 انجام شد. از تمامی شرکت­کنندگان پس از بهبودی از کووید-19 انجام شد. سیکل قاعدگی در ماه اول و چهارم و نمونه خون در ماه اول و چهارم اخذ شد. سطوح </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">،</span></span> <span dir="LTR" style="font-size:10.0pt">TSH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">،</span></span> <span dir="LTR" style="font-size:10.0pt">TPO</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> و پرولاکتین مورد بررسی قرار گرفت. </span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">در ماه اول و چهارم از نظر اختلالات قاعدگی، سطح </span></span><span dir="LTR" style="font-size:10.0pt">TPO</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">و پرولاکتین در گروه بیمار تفاوت معنیداری مشاهده نشد (05/0 </span></span><span lang="FA" style="font-size:10.0pt">></span><span dir="LTR" style="font-size:10.0pt">p</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">). میانگین سطح </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">در گروه سالم در هر دو نوبت بیشتر از گروه بیمار بود (001/0 </span></span><span lang="FA" style="font-size:10.0pt">></span><span dir="LTR" style="font-size:10.0pt">p</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">). بین </span></span><span dir="LTR" style="font-size:10.0pt">TSH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> و کووید-19 در ماه اول رابطه وجود داشت (001/0 </span></span><span lang="FA" style="font-size:10.0pt">></span><span dir="LTR" style="font-size:10.0pt">p</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) اما در ماه چهارم رابطه معنی­داری از این نظر مشاهده نشد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتیجه­ گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">اختلال عملکرد غدد درون­ریز به شکل </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> پایین و </span></span><span dir="LTR" style="font-size:10.0pt">TSH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> بالا در بین بیماران کووید-19 شایع است. با توجه به اهمیت اختلالات قاعدگی و هورمونی، به ویژه </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> و </span></span><span dir="LTR" style="font-size:10.0pt">TSH</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> و ارتباط آنها با کووید-19، سیاست­گذاران سلامت باید راه حل­های مناسبی برای کاهش عوارض بیابند.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Background: </span></b><span style="font-size:12.0pt">Coronavirus 2019 (COVID-19) has affected almost all communities throughout the world. It affects different systems in the body, which causes irreparable consequences.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Objective:</span></b><span style="font-size:12.0pt"> This study aimed to investigate the effect of the COVID-19 virus on menstrual disorders, anti-Mullerian hormone (AMH), thyroid peroxidase (TPO), thyroid stimulating hormone (TSH), and prolactin levels in women with COVID-19 disease. </span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Materials and</span></b><span style="font-size:12.0pt"> <b>Methods:</b> This prospective cohort study was conducted on 201 women (101 healthy, and 100 women with COVID-19) in </span><span style="font-size:12.0pt">Nomadic hospital, Khorramabad, Iran from February-October 2021. After recovery from COVID-19, participants were interviewed about their menstrual cycle in their 1<sup>st</sup> and 4<sup>th</sup> months. Blood samples were collected during 1<sup>st</sup> and 4<sup>th</sup> months, and AMH, TSH, TPO, and prolactin levels were assessed. </span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Results:</span></b><span style="font-size:12.0pt"> No significant differences were observed in the 1<sup>st</sup> and 4<sup>th</sup> months regarding menstrual disorders, TPO, and prolactin levels in the patient group (p > 0.05). The mean level of AMH in the healthy group was higher than the patient group in both times (p < 0.001). A relationship between TSH and COVID-19 was observed in the 1<sup>st</sup> month (p < 0.001); however, no significant relationship was observed in the 4<sup>th</sup> month, in this regard.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Conclusion:</span></b><span style="font-size:12.0pt"> Endocrine dysfunction in the form of low AMH and high TSH were common among COVID-19 patients. Due to the importance of menstrual and hormonal disorders, especially AMH and TSH, and their association with COVID-19, health policymakers should find appropriate solutions to reduce complications.</span></span></span></span></span></div>
کووید-19, آنتیمولرین هورمون, هورمون محرک تیروئید, تیروئید پراکسیداز, پرولاکتین, اختلالات قاعدگی.
COVID-19, AMH, TSH, TPO, Prolactin, Menstrual disorders.
811
820
http://ijrm.ir/browse.php?a_code=A-10-55-9&slc_lang=en&sid=1
Ziba
Haghipour
zibahaghipour@modares.ac.ir