en مقایسه نتایج تزریق اسپرم داخل سیتوپلاسمی در مردان مبتلا به آسیب نخاعی با استفاده از اسپرم به‌ دست‌آمده از روش تحریک الکتریکی انزال و استخراج اسپرم بیضه‌ای: یک مطالعه گذشته‌نگر Reproductive Andrology Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">افراد مبتلا به آسیب نخاعی </span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">(</span></span><span dir="LTR" style="font-size:10.0pt">SCI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">به دلایل مختلفی مانند کیفیت پایین اسپرم و اختلال در انزال، با نگرانی&shy;های باروری مواجه هستند. در نتیجه، تکنیک&shy;های مختلف بازیابی اسپرم از جمله استخراج اسپرم از بیضه</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">(</span></span><span dir="LTR" style="font-size:10.0pt">TESE</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) </span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و انزال الکتریکی</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> (</span></span><span dir="LTR" style="font-size:10.0pt">EE</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">برای این موارد استفاده می‌شود. </span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">با این حال، </span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">پیامدهای بالینی و نوزادی بین این دو روش به طور متناقضی گزارش شده است</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">که نیازمند بررسی بیشتر است.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف از این مطالعه، مقایسه نتایج </span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقایسه بارداری شیمیایی، بارداری بالینی و میزان تولد زنده</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در مردان مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt">SCI</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> تحت تزریق اسپرم داخل سیتوپلاسمی (</span></span><span dir="LTR" style="font-size:10.0pt">ICSI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) با استفاده از اسپرم‌های به‌دست‌آمده از دو روش </span></span><span dir="LTR" style="font-size:10.0pt">EE</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt">TESE</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بود.</span></span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه گذشته‌نگر بر روی ۳۷ مرد مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt">SCI</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> که بین سال‌های ۲۰۱۷ تا ۲۰۲۳ که </span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تحت 2 تکنیک مختلف بازیابی اسپرم قرار گرفته بودند</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> انجام شد. در ۱۸ سیکل از اسپرم حاصل از روش </span></span><span dir="LTR" style="font-size:10.0pt">EE</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> و در ۳۶ سیکل از اسپرم حاصل از روش </span></span><span dir="LTR" style="font-size:10.0pt">TESE</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> استفاده شد. </span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">سپس، میزان شیمیایی، بالینی و تولد زنده گزارش شد</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در مجموع، (8/38%) 21 بارداری شیمیایی به دست آمد. علاوه بر این، 19 مورد (18/35%) بارداری بالینی حاصل شد. میزان تولد زنده 3/20% بود. هیچ تفاوت آماری معنی‌داری بین گروه‌های </span></span><span dir="LTR" style="font-size:10.0pt">EE</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt">TESE</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">از نظر بارداری شیمیایی (4/44% در مقابل 1/36% و 55/0</span></span><span lang="AR-SA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، بارداری بالینی (</span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">3/33% در مقابل 1/36% و&nbsp; &nbsp;89/0 </span></span><span lang="AR-SA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) و یا میزان تولد زنده (</span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">2/22% در مقابل 4/19% و 81/0 </span></span><span lang="AR-SA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) مشاهده نشد. </span></span></span></span></span></span></span><br> <b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy; گیری: </span></span></b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هر دو روش تحریک </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">EE</span></span><span dir="RTL" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> و </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TESE</span></span> <span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">می‌توانند استراتژی‌های قابل اجرا برای روش‌های تزریق داخل سیتوپلاسمی اسپرم در مردان مبتلا به آسیب نخاعی باشند و هیچ تفاوتی در نتایج بارداری وجود ندارد</span></span><span style="font-size:11.0pt"><span arial="" style="font-family:">.</span></span></div> <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:normal"><b>Background:</b> Individuals with spinal cord injury (SCI) face fertility concerns due to various causes, such as low sperm quality and ejaculatory dysfunction. Consequently, different sperm retrieval techniques are used for these cases, including testicular sperm extraction (TESE) and electroejaculation (EE). Clinical and neonatal outcomes have been reported inconsistently between these 2 methods. </span><br> <span style="line-height:normal"><b>Objective:</b> This study aimed to compare the chemical pregnancy, clinical pregnancy, and live birth rate in men with SCI undergoing intracytoplasmic sperm injection using sperm obtained via EE vs. TESE.</span><br> <span style="line-height:normal"><b>Materials and Methods:</b> This retrospective cohort study was conducted between 2017 and 2023. 37 men with SCI underwent 2 different sperm retrieval techniques. Sperm was retrieved using EE in 18 cycles, while TESE was performed in 36 cycles. Then, chemical, clinical, and live birth rates were reported. </span><br> <span style="line-height:normal"><b>Results:</b> Overall, 21 (38.8%) chemical pregnancies were obtained. Moreover, 19 (35.18%) clinical pregnancies were achieved. The live birth rate was 20.3%. No statistically significant differences were observed between the EE and TESE groups in terms of chemical pregnancy (44.4% vs. 36.1%, p = 0.55), clinical pregnancy (33.3% vs. 36.1%, p = 0.89), or live birth rates (22.2% vs. 19.4%, p = 0.81). </span><br> <span style="line-height:normal"><b>Conclusion:</b> Both retrieval techniques, EE and TESE, can be applicable strategies for intracytoplasmic sperm injection procedures in men with SCI with no discrepancy in pregnancy outcomes.</span></span></span></div> آسیب نخاعی, تحریک الکتریکی انزال, استخراج اسپرم بیضه‌ای, تزریق اسپرم داخل سیتوپلاسمی, نتایج بارداری. Spinal cord injury, Sperm retrieval, Intracytoplasmic sperm injections, Pregnancy outcomes. 413 420 http://ijrm.ir/browse.php?a_code=A-10-537-1&slc_lang=en&sid=1 Saeid Haghdani saeed_haghdani@yahoo.com 0000-0002-8025-5753 Yes Andrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ., Serajoddin Vahidi vahidi.seraj@gmail.com 0009-0008-2329-7464 No Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Ali Sadeghi Alisadeghi.b@gmail.com 0000-0002-8076-7628 No Department of Surgical Technology, Faculty of Paramedical, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Narges Gholami Banadkuki Na.gholami98@gmail.com 0009-0004-9571-845X No Andrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.