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Yakubu M T, Akanji M A, Oladiji A T, Olatinwo A O, Adesokan A A, Yakubu M O, et al . Effect of Cnidoscolous aconitifolius (Miller) I.M. Johnston leaf extract on reproductive hormones of female rats. IJRM 2008; 6 (4) :149-0
URL: http://ijrm.ir/article-1-115-en.html
Effect of Cnidoscolous aconitifolius (Miller) I.M. Johnston leaf extract on reproductive hormones of female rats
Musa Toyin Yakubu * 1, Musbau Adewumi Akanji2 , Adenike Temidayo Oladiji2 , AbdulWaheed Olajide Olatinwo3 , Abdulfatai Ayoade Adesokan2 , Monsurat Oyenike Yakubu4 , Bamidele Victor Owoyele5 , Taofik Olatunde Sunmonu2 , Moyosore Salihu Ajao6
1- Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria , tomuyak@gmail.com
2- Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria
3- Department of Obstetrics and Gynecology, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
4- Department of Nursing Services, University of Ilorin Teaching Hospital, Maternity Wing, Ilorin, Nigeria
5- Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
6- Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
Abstract:   (3077 Views)
Background: The increase in the rate of infertility in women has prompted the need to search for plants with antifertility potentials.
Objective: The effect of administration of aqueous extract of Cnidoscolous aconitifolius leaves for seven days on reproductive hormones of female Wistar rats was investigated.
Materials and Methods: Sixty female albino rats were grouped into four (A, B, C and D) of 15 each. Group A (the control) received orally 6.5 ml kg-1 body weight of distilled water on daily basis for 7 days. Groups B, C and D were treated like the control except that they received 250, 500 and 1000 mg kg-1 body weight of the extract.
Results: Phytochemical screening of the extract revealed the presence of alkaloids, saponins, phenolics, tannins, flavonoids, anthraquinones, phlobatannins and triterpenes. Administration of the extract produced significant increase (p<0.05) in the serum prolactin concentration whereas those of estradiol, progesterone, follicle stimulating and luteinizing hormones were significantly reduced.
Conclusion: The alterations in the female rat reproductive hormones by the extract are indications of adverse effect on the maturation and ovulation of follicles. Consequently, the extract may impair fertility and conception in female rats. Thus, the Cnidoscolous aconitifolius leaf extract may be explored as a female contraceptive.
Keywords: Cnidoscolous aconitifolius, Prolactin, Follicle stimulating hormone, Luteinizing hormone, Estradiol, Progesterone, Fertility, Conception, Contraceptive
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Type of Study: Original Article |
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