Reddy R, Mutreja D, Mukhopadhyay I, Moorchung N. Prothrombin gene mutations do not cause
recurrent pregnancy loss in the Indian
population. IJRM 2019; 17 (5) :375-376
URL:
http://ijrm.ir/article-1-1521-fa.html
Prothrombin gene mutations do not cause
recurrent pregnancy loss in the Indian
population. International Journal of Reproductive BioMedicine. 1398; 17 (5) :375-376
URL: http://ijrm.ir/article-1-1521-fa.html
چکیده: (1856 مشاهده)
As defined by the American Society of Reproductive Medicine, recurrent miscarriage or recurrent pregnancy loss is defined as two or more failed pregnancies. (1). There are various causes for RPL and yet, in about 40% of cases, no cause can be identified after extensive investigation. It is believed that inherited and acquired thrombophilia like Protein C/S deficiency and genetic mutations in the Factor V and the Prothrombin gene maybe a cause of RPL (2). There is a significant association between the Prothrombin G2021M mutation (PTG) with RPL which has been shown by numerous other studies (3).
The data with respect to PTG G20210A mutations and its association with RPL is scant in Indian population.