International Journal of
Reproductive Biomedicine
Sun, Dec 22, 2024
[Archive]
Volume 17, Issue 8 (August 2019)
IJRM 2019, 17(8): 551-556 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
karamolahi S, Salman Yazdi R, Zangeneh M, Jamshidi Makiani M, farhoodi B, Sedighi Gilani M A. Impact of hepatitis B virus and hepatitis C virus infection on sperm parameters of infertile men . IJRM 2019; 17 (8) :551-556
URL: http://ijrm.ir/article-1-1616-en.html
URL: http://ijrm.ir/article-1-1616-en.html
Sana karamolahi1 
, Reza Salman Yazdi2 , Mehrangiz Zangeneh * 3, Mahin Jamshidi Makiani4 , Behnam farhoodi5 , Mohammad Ali Sedighi Gilani6
, Reza Salman Yazdi2 , Mehrangiz Zangeneh * 3, Mahin Jamshidi Makiani4 , Behnam farhoodi5 , Mohammad Ali Sedighi Gilani6
1- Tehran Medical Sciences, Branch Islamic Azad University, Tehran, Iran.
2- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
3- Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran ,zangeneh4@yahoo.com
4- Antimicrobial Resistance Research Center, Institute of Immunology & Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
5- Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
6- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
2- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
3- Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran ,
4- Antimicrobial Resistance Research Center, Institute of Immunology & Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
5- Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
6- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Abstract: (3614 Views)
Abstract
Background: Viral hepatitis is one of the health problems which have the effects on the health issues. It seems that hepatitis B virus (HBV) and hepatitis C virus (HCV) infection have negative impacts on the semen quality and male infertility rate.
Objective: In this study, we aimed to evaluate the effects of HBV and HCV on sperm quality among Iranian infertile men referred to Royan Institute Reproductive Biomedicine Research Center between 2003 and 2014.
Material and Methods: This retrospective case-control study included 112 HBV positive infertile men and 47 HCV positive infertile men as case group and 112 HBV negative and HCV negative matched infertile men as a control group. All semen analysis and viral parameters assessment was performed in the central laboratory with the same method and instruments.
Results: Sperm count among infertile men with HBV and HCV infection was significantly lower than control group [the mean of the total sperm count 100.95 ± 118.59, 118.22 ± 141.18, 166.27 ± 151.25 (p < 0.001)]. Sperm motility was significantly decreased in HBV and HCV positive men in comparison to the control group [30.97 ± 25.88, 31.09 ± 28.72, 40.87 ± 23.37, respectively (p < 0.007)]. The percentage of normal sperm morphology was significantly higher in control group in comparison to HBV and HCV infected group [the mean of the normal semen morphology 3.23 ± 3.27, 3.70 ± 3.83, 4.51 ± 3.15 p< 0.015]. Although there is a significant decline in liquefaction time in the case group but the viscosity, semen volume, and PH of semen samples were similar in the both case and control groups.
Conclusion: Our results suggest that HBV and HCV infection are associated with poor sperm quality.
Background: Viral hepatitis is one of the health problems which have the effects on the health issues. It seems that hepatitis B virus (HBV) and hepatitis C virus (HCV) infection have negative impacts on the semen quality and male infertility rate.
Objective: In this study, we aimed to evaluate the effects of HBV and HCV on sperm quality among Iranian infertile men referred to Royan Institute Reproductive Biomedicine Research Center between 2003 and 2014.
Material and Methods: This retrospective case-control study included 112 HBV positive infertile men and 47 HCV positive infertile men as case group and 112 HBV negative and HCV negative matched infertile men as a control group. All semen analysis and viral parameters assessment was performed in the central laboratory with the same method and instruments.
Results: Sperm count among infertile men with HBV and HCV infection was significantly lower than control group [the mean of the total sperm count 100.95 ± 118.59, 118.22 ± 141.18, 166.27 ± 151.25 (p < 0.001)]. Sperm motility was significantly decreased in HBV and HCV positive men in comparison to the control group [30.97 ± 25.88, 31.09 ± 28.72, 40.87 ± 23.37, respectively (p < 0.007)]. The percentage of normal sperm morphology was significantly higher in control group in comparison to HBV and HCV infected group [the mean of the normal semen morphology 3.23 ± 3.27, 3.70 ± 3.83, 4.51 ± 3.15 p< 0.015]. Although there is a significant decline in liquefaction time in the case group but the viscosity, semen volume, and PH of semen samples were similar in the both case and control groups.
Conclusion: Our results suggest that HBV and HCV infection are associated with poor sperm quality.
Type of Study: Original Article |
References
1. Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Liu HX, et al. Effects of hepatitis B virus infection on human sperm chromosomes. World J Gastroenterol 2003; 9: 736-740. [DOI:10.3748/wjg.v9.i4.736]
2. World Health Organization. Introduction of hepatits B Vaccine into chidhood immunization services. Geneva: World Health Organization; 2001.
3. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007; 45: 507-539. [DOI:10.1002/hep.21513]
4. Vahidi S, Ardalan A, Mohammad K. The epidemiology of primary infertility in the Islamic Republic of Iran in 2004-5. J Reprod Infertil 2006; 7: 243-251.
5. Duran HE, Morshedi M, Kruger T, Oehninger S. Intrauterine insemination: a systematic review on determinants of success. Hum Reprod Update 2002; 8: 373-384. [DOI:10.1093/humupd/8.4.373]
6. Lorusso F, Palmisano M, Chironna M, Vacca M, Masciandaro P, Bassi E, et al. Impact of chronic viral diseases on semen parameters. Andrologia 2010; 42: 121-126. [DOI:10.1111/j.1439-0272.2009.00970.x]
7. Moretti E, Federico MG, Giannerini V, Collodel G. Sperm ultrastructure and meiotic segregation in a group of patients with chronic hepatitis B and C. Andrologia 2008; 40: 286-291. [DOI:10.1111/j.1439-0272.2008.00855.x]
8. Vicari E, Arcoria D, Di Mauro C, Noto R, Noto Z, La Vignera S. Sperm output in patients with primary infertility and hepatitis B or C virus; negative influence of HBV infection during concomitant varicocele. Minerva Med 2006; 97: 65-77.
9. Hussein TM, Elneily D, Eid AA, Abou-ElKhier H. Assessment of anti-sperm antibodies in a sample of Egyptian patients with hepatitis C virus infection. Andrologia 2017; 49: e12664. [DOI:10.1111/and.12664]
10. Walsh TJ, Turek PJ. Immunologic infertility. In: Lipshultz LI, Howards SS, Niederberger CS, editors. Infertility in the male. 4th Ed. New York, Cambridge University Press; 2009: 227-294.
11. Alexander NJ. Antibodies to human spermatozoa impede sperm penetration of cervical mucus or hamster eggs. Fertil Steril 1984; 41: 433-439. [DOI:10.1016/S0015-0282(16)47724-1]
12. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th Ed. Switzerland: World Health Organization; 2001.
13. Garolla A, Pizzol D, Bertoldo A, Menegazzo M, Barzon L, Foresta C. Sperm viral infection and male infertility: focus on HBV, HCV, HIV, HPV, HSV, HCMV, and AAV. J Reprod Immunol 2013; 100: 20-29. [DOI:10.1016/j.jri.2013.03.004]
14. Huret JL, Jeulin C, Hadchouel M, Scotto J, Molinie C. Semen abnormalities in patients with viral hepatitis B. Arch Androl 1986; 17: 99-100. [DOI:10.3109/01485018608986961]
15. Durazzo M, Premoli A, Di Bisceglie C, Bertagna A, Faga E, Biroli G, et al. Alterations of seminal and hormonal parameters: An extrahepatic manifestation of HCV infection? World J Gastroenterol 2006; 12: 3073-3076. [DOI:10.3748/wjg.v12.i19.3073]
16. Garrido N, Meseguer M, Remohi J, Simon C, Pellicer A. Semen characteristics in human immunodeficiency virus (HIV)- and hepatitis C (HCV)-seropositive males: predictors of the success of viral removal after sperm washing. Hum Reprod 2005; 20: 1028-1034. [DOI:10.1093/humrep/deh699]
17. Hofny ER, Ali ME, Taha EA, Nafeh HM, Sayed DS, Abdel-Azeem HG, et al. Semen and hormonal parameters in men with chronic hepatitis C infection. Fertil Steril 2011; 95: 2557-2559. [DOI:10.1016/j.fertnstert.2011.05.014]
18. Zhou XP, Hu XL, Zhu YM, Qu F, Sun SJ, Qian YL. Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B. Asian J Androl 2011; 13: 465-469. [DOI:10.1038/aja.2010.164]
19. Su FH, Chang SN, Sung FC, Su CT, Shieh YH, Lin CC, et al. Hepatitis B virus infection and the risk of male infertility: a population-based analysis. Fertil Steril 2014; 102: 1677-1684. [DOI:10.1016/j.fertnstert.2014.09.017]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
