دوره 17، شماره 9 - ( 6-1398 )                   جلد 17 شماره 9 صفحات 620-603 | برگشت به فهرست نسخه ها

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Mohammadzadeh F, Dolatian M, Jorjani M, Afrakhteh M, Alavi Majd H, Abdi F et al . Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis . IJRM 2019; 17 (9) :603-620
URL: http://ijrm.ir/article-1-1636-fa.html
شکست درمان با آزیترومایسین در کلامیدیا تراکوماتیس اوروژنیتال: مرور سیستماتیک و متاآنالیز. International Journal of Reproductive BioMedicine. 1398; 17 (9) :603-620

URL: http://ijrm.ir/article-1-1636-fa.html

شکست درمان با آزیترومایسین در کلامیدیا تراکوماتیس اوروژنیتال: مرور سیستماتیک و متاآنالیز
چکیده:   (6549 مشاهده)
مقدمه: کلامیدیا تراکوماتیس یکی از شایع‌ترین پاتوژن‌های منتقله از راه دستگاه تناسلی در انسان است که منجر به بروز عفونت اوروژنیتال می­گردد.
 هدف: با توجه به شیوع بالای این عفونت کلامیدیا و پیامدهای نامطلوب آن بر سلامت زنان و مردان، این مطالعه متاآنالیز با هدف تعیین میزان شکست درمان با آزیترومایسین انجام گرفت.
موارد و روش­ها: پایگاه­های اطلاعاتیMEDLINE ، ISI Web of Science، PubMed، EMBASE، Scopus، ProQuest و Science Direct برای مقالاتی که از سال 1991 تا 2018 منتشر شده بود مورد بررسی قرار گرفتند. برای ارزیابی کیفیت مطالعات انتخاب شده، از Cochrane Risk of Bias Assessment Tool استفاده شد. از 12 و کوکران کیو-تست برای تعیین هتروژنیسیتی استفاده شد. برای مقایسه شیوع در سطوح مختلف متغیرها از روش Subgroup analysis and meta-regression استفاده شده است.
نتایج: 21 مطالعه که معیارهای ورود را دارا بودند در نهایت تجزیه و تحلیل شد. برآورد تلفیقی میزان شکست آزیترومایسین 23/11% بود. همچنین درصد شکست آزیترومایسین در درمان اورتریت (87/15%)، سرویسیت (41/7%) و ژنیتال کلامیدیا (14/7%) بود. برآورد تلفیقی تفاوت میزان شکست 37/2% بود که نشان می­دهد شکست درمان آزیترومایسین در درمان کلامیدیا نسبت به داکسی­سیکلین و سایر داروهای مورد بررسی در مطالعه بیشتر می­باشد. نتایج متارگرسیون حاکی از آن بود که سن بیماران در ایجاد هتروژنیسیتی برای درصد شکست درمان آزیترومایسین تاثیر معنی­داری داشت (826/0, ß= 017/0p= ).
نتیجه ­گیری: شکست درمان با آزیترومایسین در عفونت­های کلامیدیایی اوروژنیتال نسبت به داکسی­سیکلین و سایر داروهای مورد بررسی در مطالعه بیشتر   می­باشد.
واژه‌های کلیدی: آزیترومایسین، کلامیدیا تراکوماتیس، شکست درمان
متن کامل مقاله [PDF 1505 kb]   (727 دریافت)    
نوع مطالعه: Review article |
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