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Volume 8, Issue 2 (7-2010)
IJRM 2010, 8(2): 60-65 |
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Eidi M, Eidi A, Pouyan O, Shahmohammadi P, Fazaeli R, Bahar M. Seminal plasma levels of copper and its relationship with seminal parameters. IJRM 2010; 8 (2) :60-65
URL: http://ijrm.ir/article-1-179-en.html
URL: http://ijrm.ir/article-1-179-en.html
1- Department of Biology, Varamin Branch, Islamic Azad University, Varamin, Iran , eidi@iauvaramin.ac.ir
2- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3- Department of IVF, Shariati Hospital, Tehran, Iran
4- Department of Biology, Varamin Branch, Islamic Azad University, Varamin, Iran
5- Department of Chemistry, South Tehran Branch, Islamic Azad University, Tehran, Iran
6- Department of Medical Genetics, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran
2- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3- Department of IVF, Shariati Hospital, Tehran, Iran
4- Department of Biology, Varamin Branch, Islamic Azad University, Varamin, Iran
5- Department of Chemistry, South Tehran Branch, Islamic Azad University, Tehran, Iran
6- Department of Medical Genetics, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran
Abstract: (2467 Views)
Background: The trace element copper has been identified as a highly toxic element for sperm. It is known to affect sperm motility in humans and experimental implantation of copper in the epididymis vas deferens and scrotum of mammals has been demonstrated to affect fertility detrimentally. Objective: Sperm concentration motility vitality and morphology are parameters used to evaluate potential male fertility. Since copper is believed to be important for spermatogenesis; we conducted a study to investigate the correlation between seminal plasma copper concentration and human semen parameters in 232 males.
Materials and Methods: We selected 232 subfertile or infertile men who referred to Omid Fertility Clinic randomly. Samples were categorized into normospermic (n=32) oligozospermic (n=73) asthenozospermic (n=111) and azospermic (n=16) groups according to their spermiogrames. Total seminal plasma copper concentration was determined by furnace atomic absorption spectrophotometer.
Results: The results showed that seminal plasma copper concentrations in oligozospermic asthenozospermic and azospermic groups are significantly higher than normozospermic group (p<0.01). Also, negative correlations were found between seminal plasma copper concentration and sperm count (p<0.05), sperm motility (p<0.01), sperm vitality (p<0.01), normal morphology (p<0.01) and pH (p<0.01) in all groups.
Conclusion: It was suggested that excess copper in seminal plasma was detrimental for male reproductive capacity by reducing sperm count, motility, vitality and morphology.
Materials and Methods: We selected 232 subfertile or infertile men who referred to Omid Fertility Clinic randomly. Samples were categorized into normospermic (n=32) oligozospermic (n=73) asthenozospermic (n=111) and azospermic (n=16) groups according to their spermiogrames. Total seminal plasma copper concentration was determined by furnace atomic absorption spectrophotometer.
Results: The results showed that seminal plasma copper concentrations in oligozospermic asthenozospermic and azospermic groups are significantly higher than normozospermic group (p<0.01). Also, negative correlations were found between seminal plasma copper concentration and sperm count (p<0.05), sperm motility (p<0.01), sperm vitality (p<0.01), normal morphology (p<0.01) and pH (p<0.01) in all groups.
Conclusion: It was suggested that excess copper in seminal plasma was detrimental for male reproductive capacity by reducing sperm count, motility, vitality and morphology.
Type of Study: Original Article |
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