International Journal of
Reproductive Biomedicine
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Volume 19, Issue 10 (October 2021)
IJRM 2021, 19(10): 899-908 |
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Azuka Okafor I, Somtochukwu Nnamah U, Ndukwe V. Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study. IJRM 2021; 19 (10) :899-908
URL: http://ijrm.ir/article-1-1858-en.html
URL: http://ijrm.ir/article-1-1858-en.html
1- Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria. Department of Obstetrics and Gynecology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Nigeria. Pan African University of Life and Earth Science Institute (Including Health and Agriculture) PAULESI, University of Ibadan, Ibadan, Nigeria. , okaforizuchukwu33@gmail.com
2- Hematology Department, Babcock University Teaching Hospital, Ilisan Remo, Ogun State, Nigeria.
3- Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.
2- Hematology Department, Babcock University Teaching Hospital, Ilisan Remo, Ogun State, Nigeria.
3- Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.
Abstract: (1707 Views)
Background: Portulaca oleracea (PO) is a widely known plant utilized for its medicinal attributes in the treatment of different illnesses.
Objective: To investigate the effect of methanolic extract of PO (MEPO) on ovariectomy-induced reproductive toxicity in normal cyclic rats.
Materials and Methods: Twenty 10-wk-old normal cyclic rats weighing 110-200 g were randomly divided into four groups (n = 5/group). Group A served as the control and received distilled water only. Group B was ovariectomized without treatment, while groups C and D were ovariectomized but treated with 400 and 800 mg/kg of MEPO, respectively, for 14 days. At the end of the experiment, body weight, serum hormonal levels, and estrous cycles were monitored across the groups.
Results: Groups B, C, and D showed estrous cycle dysregulation and specific phase arrest when compared with the control. While a significant decrease in estradiol (p ≤ 0.001) and testosterone levels (p ≤ 0.001) were observed in groups B, C, and D, only groups C and D showed a significant increase in progesterone level when compared with the control (p ≤ 0.001, p = 0.01, respectively).
Conclusion: The administration of 400 and 800 mg/kg MEPO is ineffective in ameliorating estrous cycle disruption and hormonal changes seen in ovariectomized normal cyclic adult Wistar rats.
Objective: To investigate the effect of methanolic extract of PO (MEPO) on ovariectomy-induced reproductive toxicity in normal cyclic rats.
Materials and Methods: Twenty 10-wk-old normal cyclic rats weighing 110-200 g were randomly divided into four groups (n = 5/group). Group A served as the control and received distilled water only. Group B was ovariectomized without treatment, while groups C and D were ovariectomized but treated with 400 and 800 mg/kg of MEPO, respectively, for 14 days. At the end of the experiment, body weight, serum hormonal levels, and estrous cycles were monitored across the groups.
Results: Groups B, C, and D showed estrous cycle dysregulation and specific phase arrest when compared with the control. While a significant decrease in estradiol (p ≤ 0.001) and testosterone levels (p ≤ 0.001) were observed in groups B, C, and D, only groups C and D showed a significant increase in progesterone level when compared with the control (p ≤ 0.001, p = 0.01, respectively).
Conclusion: The administration of 400 and 800 mg/kg MEPO is ineffective in ameliorating estrous cycle disruption and hormonal changes seen in ovariectomized normal cyclic adult Wistar rats.
Type of Study: Original Article |
Subject:
Reproductive Biology
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