Volume 20, Issue 5 (May 2022)
IJRM 2022, 20(5): 389-398 |
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Mehran Nouri1 
, Sanaz Mehrabani2 , Hosein Firoozbakht3 , Elmira Vatanian4 , Homayoun Abbasi5 , Mahsa Shirani * 6
, Sanaz Mehrabani2 , Hosein Firoozbakht3 , Elmira Vatanian4 , Homayoun Abbasi5 , Mahsa Shirani * 6
1- Students’ Research Committee, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
4- Department of Cellular and Molecular Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Science, Tehran, Iran.
5- Isfahan Fertility and Infertility Center, Isfahan, Iran.
6- Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Students’ Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. , mahsa.shirani1373@yahoo.com
2- Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
4- Department of Cellular and Molecular Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Science, Tehran, Iran.
5- Isfahan Fertility and Infertility Center, Isfahan, Iran.
6- Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Students’ Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. , mahsa.shirani1373@yahoo.com
Abstract: (1002 Views)
Background: Infertility has been a significant problem for couples in recent decades, and the issue can often lie with the male rather than the female.
Objective: This study aimed to investigate the effects of fats and minerals intake on semen parameters in infertile men.
Materials and Methods: This cross-sectional study was performed on 260 infertile men referred to Isfahan Infertility Clinic, Isfahan, Iran in the summer of 2018. Semen parameters regarding sperm concentration, total motility, normal morphology, and sperm volume were considered. To assess dietary intakes, a validated food frequency questionnaire was used.
Results: In the adjusted model, the prevalence of abnormal concentration was 5.23 times higher in the top quartile of calcium intake, compared with the bottom quartile (p = 0.03). Also, the prevalence of abnormal morphology was 68% lower in the third quartile of calcium intake (p = 0.03). Additionally, the prevalence of abnormal concentration was 84% lower in the top quartile of folate intake in comparison to the bottom quartile (p = 0.01) and the prevalence of abnormal morphology was 70% lower in the top quartile of folate intake (p = 0.03). Additionally, the prevalence of abnormal concentration was 72% lower in the top quartile of selenium intake in comparison to the bottom quartile (p = 0.04). Furthermore, in the crude model, the prevalence of abnormal volume was 64% lower in the second quartile of linoleic acid intake rather than the first quartile (p = 0.01).
Conclusion: In conclusion, diets containing higher amounts of folate and selenium, and lower amounts of cholesterol, saturated fatty acid and calcium were associated with more favorable semen quality parameters.
Objective: This study aimed to investigate the effects of fats and minerals intake on semen parameters in infertile men.
Materials and Methods: This cross-sectional study was performed on 260 infertile men referred to Isfahan Infertility Clinic, Isfahan, Iran in the summer of 2018. Semen parameters regarding sperm concentration, total motility, normal morphology, and sperm volume were considered. To assess dietary intakes, a validated food frequency questionnaire was used.
Results: In the adjusted model, the prevalence of abnormal concentration was 5.23 times higher in the top quartile of calcium intake, compared with the bottom quartile (p = 0.03). Also, the prevalence of abnormal morphology was 68% lower in the third quartile of calcium intake (p = 0.03). Additionally, the prevalence of abnormal concentration was 84% lower in the top quartile of folate intake in comparison to the bottom quartile (p = 0.01) and the prevalence of abnormal morphology was 70% lower in the top quartile of folate intake (p = 0.03). Additionally, the prevalence of abnormal concentration was 72% lower in the top quartile of selenium intake in comparison to the bottom quartile (p = 0.04). Furthermore, in the crude model, the prevalence of abnormal volume was 64% lower in the second quartile of linoleic acid intake rather than the first quartile (p = 0.01).
Conclusion: In conclusion, diets containing higher amounts of folate and selenium, and lower amounts of cholesterol, saturated fatty acid and calcium were associated with more favorable semen quality parameters.
Type of Study: Original Article |
Subject:
Fertility & Infertility
References
1. Benedetti S, Tagliamonte MC, Catalani S, Primiterra M, Canestrari F, De Stefani S, et al. Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality. Reprod Biomed Online 2012; 25: 300-306. [DOI:10.1016/j.rbmo.2012.05.011] [PMID]
2. Aflakseir A, Mahdiyar M. The role of religious coping strategies in predicting depression among a sample of women with fertility problems in Shiraz. J Reprod Infertil 2016; 17: 117-122.
3. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The international committee for monitoring assisted reproductive technology (ICMART) and the world health organization (WHO) revised glossary on ART terminology, 2009. Hum Reprod 2009; 24: 2683-2687. [DOI:10.1093/humrep/dep343] [PMID]
4. Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N. Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod 2017; 32: 215-222. [DOI:10.1093/humrep/dew288] [PMID]
5. Gabrielsen JS, Tanrikut C. Chronic exposures and male fertility: The impacts of environment, diet, and drug use on spermatogenesis. Andrology 2016; 4: 648-661. [DOI:10.1111/andr.12198] [PMID]
6. Lancellotti TES, Boarelli PV, Monclus MA, Cabrillana ME, Clementi MA, Espínola LS, et al. Hypercholesterolemia impaired sperm functionality in rabbits. PLoS One 2010; 5: e13457. [DOI:10.1371/journal.pone.0013457] [PMID] [PMCID]
7. Dadkhah H, Kazemi A, Nasr-Isfahani MH, Ehsanpour S. The relationship between the amount of saturated fat intake and semen quality in men. Iran J Nurs Midwif Res 2017; 22: 46-50. [DOI:10.4103/1735-9066.202067] [PMID] [PMCID]
8. Eslamian Gh, Amirjannati N, Rashidkhani B, Sadeghi MR, Baghestani AR, Hekmatdoost A. Dietary fatty acid intakes and asthenozoospermia: A case-control study. Fertil Steril 2015; 103: 190-198. [DOI:10.1016/j.fertnstert.2014.10.010] [PMID]
9. Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod 2012; 27: 1466-1474. [DOI:10.1093/humrep/des065] [PMID] [PMCID]
10. Moslemi MK, Tavanbakhsh S. Selenium-vitamin E supplementation in infertile men: Effects on semen parameters and pregnancy rate. Int J Gen Med 2011; 4: 99-104. [DOI:10.2147/IJGM.S16275] [PMID] [PMCID]
11. Ammar O, Houas Z, Mehdi M. The association between iron, calcium, and oxidative stress in seminal plasma and sperm quality. Environ Sci Pollut Res Int 2019; 26: 14097-14105. [DOI:10.1007/s11356-019-04575-7] [PMID]
12. Fallah A, Mohammad-Hasani A, Colagar AH. Zinc is an essential element for male fertility: A review of Zn roles in men's health, germination, sperm quality, and fertilization. J Reprod Infertil 2018; 19: 69-81.
13. Biswas TK, Pandit S, Mondal S, Biswas SK, Jana U, Ghosh T, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia 2010; 42: 48-56. [DOI:10.1111/j.1439-0272.2009.00956.x] [PMID]
14. Morselli MG, Colombo M, Faustini M, Luvoni GC. Morphological indices for canine spermatozoa based on the World Health Organization laboratory manual for human semen. Reprod Domest Anim 2019; 54: 949-955. [DOI:10.1111/rda.13440] [PMID]
15. Mirmiran P, Hosseini Esfahani F, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr 2010; 13: 654-662. [DOI:10.1017/S1368980009991698] [PMID]
16. Wilhelm AL, Maquivar MG, Bas S, Brick TA, Weiss WP, Bothe H, et al. Effect of serum calcium status at calving on survival, health, and performance of postpartum Holstein cows and calves under certified organic management. J Dairy Sci 2017; 100: 3059-3067. [DOI:10.3168/jds.2016-11743] [PMID]
17. Chamberlin WG, Middleton JR, Spain JN, Johnson GC, Ellersieck MR, Pithua P. Subclinical hypocalcemia, plasma biochemical parameters, lipid metabolism, postpartum disease, and fertility in postparturient dairy cows. J Dairy Sci 2013; 96: 7001-7013. [DOI:10.3168/jds.2013-6901] [PMID]
18. Rosol TJ, Capen C. Calcium-regulating hormones and diseases of abnormal mineral (calcium, phosphorus, magnesium) metabolism. In: Kaneko JJ, Harvey JW, Bruss ML. Clinical biochemistry of domestic animals. 5th Ed. San Diego: Academic Press; 1997. [DOI:10.1016/B978-012396305-5/50024-5]
19. Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi MR, Hekmatdoost A. Nutrient patterns and asthenozoospermia: A case-control study. Andrologia 2017; 49: e12624. [DOI:10.1111/and.12624] [PMID]
20. Afeiche M, Williams PL, Mendiola J, Gaskins AJ, Jørgensen N, Swan SH, et al. Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men. Hum Reprod 2013; 28: 2265-2275. [DOI:10.1093/humrep/det133] [PMID] [PMCID]
21. Afeiche MC, Bridges ND, Williams PL, Gaskins AJ, Tanrikut C, Petrozza JC, et al. Dairy intake and semen quality among men attending a fertility clinic. Fertil Steril 2014; 101: 1280-1287. [DOI:10.1016/j.fertnstert.2014.02.003] [PMID] [PMCID]
22. Ross C, Morriss A, Khairy M, Khalaf Y, Braude P, Coomarasamy A, et al. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online 2010; 20: 711-723. [DOI:10.1016/j.rbmo.2010.03.008] [PMID]
23. Showell MG, Mackenzie‐Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev 2014; 12: CD007411. [DOI:10.1002/14651858.CD007411.pub3] [PMID]
24. Aitken RJ, Gibb Z, Baker MA, Drevet J, Gharagozloo P. Causes and consequences of oxidative stress in spermatozoa. Reprod Fertil Dev 2016; 28: 1-10. [DOI:10.1071/RD15325] [PMID]
25. Gharagozloo P, Aitken RJ. The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum Reprod 2011; 26: 1628-1640. [DOI:10.1093/humrep/der132] [PMID]
26. Ahsan U, Kamran Z, Raza I, Ahmad S, Babar W, Riaz M, et al. Role of selenium in male reproduction: A review. Anim Reprod Sci 2014; 146: 55-62. [DOI:10.1016/j.anireprosci.2014.01.009] [PMID]
27. Molloy AM. Genetic aspects of folate metabolism. Subcell Biochecm 2012; 56: 105-130. [DOI:10.1007/978-94-007-2199-9_7] [PMID]
28. Wong WY, Merkus HMWM, Thomas ChMG, Menkveld R, Zielhuis GA, Steegers-Theunissen RPM. Effects of folic acid and zinc sulfate on male factor subfertility: A double-blind, randomized, placebo-controlled trial. Fertil Steril 2002; 77: 491-498. [DOI:10.1016/S0015-0282(01)03229-0]
29. Aarabi M, Christensen KE, Chan D, Leclerc D, Landry M, Ly L, et al. Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation. Hum Mol Genet 2018; 27: 1123-1135. [DOI:10.1093/hmg/ddy021] [PMID] [PMCID]
30. Chavarro JE, Mínguez-Alarcón L, Mendiola J, Cutillas-Tolín A, López-Espín JJ, Torres-Cantero AM. Trans fatty acid intake is inversely related to total sperm count in young healthy men. Hum Reprod 2014; 29: 429-440.
https://doi.org/10.1093/humrep/deu059 [DOI:10.1093/humrep/det464] [PMID]
31. Fair S, Doyle DN, Diskin MG, Hennessy AA, Kenny DA. The effect of dietary n-3 polyunsaturated fatty acids supplementation of rams on semen quality and subsequent quality of liquid stored semen. Theriogenology 2014; 81: 210-219. [DOI:10.1016/j.theriogenology.2013.09.002] [PMID]
32. Bachir BG, Jarvi K. Infectious, inflammatory, and immunologic conditions resulting in male infertility. Urol Clin North Am 2014; 41: 67-81. [DOI:10.1016/j.ucl.2013.08.008] [PMID]
33. Morielli T, O'Flaherty C. Oxidative stress impairs function and increases redox protein modifications in human spermatozoa. Reproduction 2015; 149: 113-123. [DOI:10.1530/REP-14-0240] [PMID] [PMCID]
34. Ferramosca A, Moscatelli N, Di Giacomo M, Zara V. Dietary fatty acids influence sperm quality and function. Andrology 2017; 5: 423-430. [DOI:10.1111/andr.12348] [PMID]
35. Gürler H, Calisici O, Calisici D, Bollwein H. Effects of feeding omega-3-fatty acids on fatty acid composition and quality of bovine sperm and on antioxidative capacity of bovine seminal plasma. Anim Reprod Sci 2015; 160: 97-104. [DOI:10.1016/j.anireprosci.2015.07.010] [PMID]
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