International Journal of
Reproductive Biomedicine
Sat, Dec 21, 2024
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Volume 20, Issue 7 (July 2022)
IJRM 2022, 20(7): 591-600 |
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Mansour Ghanaei M, Asgharnia M, Farokhfar M, Asghari Ghalebin S M, Rafie E, Haryalchi K. The effect of consuming evening primrose oil on cervical preparation before hysteroscopy: An RCT. IJRM 2022; 20 (7) :591-600
URL: http://ijrm.ir/article-1-2301-en.html
URL: http://ijrm.ir/article-1-2301-en.html
Mandana Mansour Ghanaei1 
, Maryam Asgharnia2 , Maryam Farokhfar1 , Seyed Mohammah Asghari Ghalebin1 , Elahe Rafie3 , Katayoun Haryalchi * 4
, Maryam Asgharnia2 , Maryam Farokhfar1 , Seyed Mohammah Asghari Ghalebin1 , Elahe Rafie3 , Katayoun Haryalchi * 4
1- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Razi Clinical Research Development Unit, Guilan University of Medical Science, Rasht, Iran.
4- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. ,K_haryalchi@yahoo.com
2- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Razi Clinical Research Development Unit, Guilan University of Medical Science, Rasht, Iran.
4- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (1047 Views)
Background: Herbal medicine could be effective at treating various illnesses. Hysteroscopy can be as an effective method for assessing the uterus in terms of anatomical, physiological and pathological anomalies.
Objective: This study aims to evaluate the effect of evening primrose oil (EPO) on cervical preparation in women candidates for hysteroscopy.
Materials and Methods: This study was a double-blind, randomized controlled clinical trial including 160 women candidates for diagnostic hysteroscopy who were referred to Al-zahra hospital from August 2019-March 2020. They were divided in 2 groups. Group A received 100 mg EPO as a soft gel capsule 6 hr before the hysterectomy in the posterior vaginal fornix. Group B received a placebo. After receiving the treatment, primary and secondary outcomes were evaluated in gropus.
Results: The average Hegar size in the EPO group was larger than in the control group (p < 0.001, for both). Also, the need for mechanical dilation, the time taken until the first resistance and the time of dilatation completion in the EPO group were significantly less than in the placebo group (p < 0.008 for all). There was also greater ease of dilatation in the EPO group. Side effects such as uterine rupture, false passage, cervical rupture, allergic reaction, abdominal pain, nausea, diarrhea, headache and increase of bowel movements were not reported in any cases.
Conclusion: Based on the findings of the present study, EPO is effective for cervical preparation in women undergoing hysteroscopy.
Objective: This study aims to evaluate the effect of evening primrose oil (EPO) on cervical preparation in women candidates for hysteroscopy.
Materials and Methods: This study was a double-blind, randomized controlled clinical trial including 160 women candidates for diagnostic hysteroscopy who were referred to Al-zahra hospital from August 2019-March 2020. They were divided in 2 groups. Group A received 100 mg EPO as a soft gel capsule 6 hr before the hysterectomy in the posterior vaginal fornix. Group B received a placebo. After receiving the treatment, primary and secondary outcomes were evaluated in gropus.
Results: The average Hegar size in the EPO group was larger than in the control group (p < 0.001, for both). Also, the need for mechanical dilation, the time taken until the first resistance and the time of dilatation completion in the EPO group were significantly less than in the placebo group (p < 0.008 for all). There was also greater ease of dilatation in the EPO group. Side effects such as uterine rupture, false passage, cervical rupture, allergic reaction, abdominal pain, nausea, diarrhea, headache and increase of bowel movements were not reported in any cases.
Conclusion: Based on the findings of the present study, EPO is effective for cervical preparation in women undergoing hysteroscopy.
Type of Study: Original Article |
Subject:
Reproductive Urology
References
1. Al-Fozan H, Firwana B, Al Kadri H, Hassan S, Tulandi T. Preoperative ripening of the cervix before operative hysteroscopy. Cochrane Database Syst Rev 2015; 4: Cd005998. [DOI:10.1002/14651858.CD005998.pub2] [PMID]
2. Stankova T, Ganovska A, Stoianova M, Kovachev S. Complications of diagnostic and operative hysteroscopy: Review. Akush Ginekol 2015; 54: 21-27. (in Bulgarian)
3. Manchanda R., Sharma R. Complications of hysteroscopy and management. In: Tandulwadkar S., Pal B. Hysteroscopy simplified by masters. Singapore: Springer; 2021. [DOI:10.1007/978-981-15-2505-6_26]
4. Kotdawala P, Kotdawala S, Nagar N. Evaluation of endometrium in peri-menopausal abnormal uterine bleeding. J Midlife Health 2013; 4: 16-21. [DOI:10.4103/0976-7800.109628] [PMID] [PMCID]
5. Gupta S. Complications of hysteroscopy. In: Jain S, Amdar D. Manual of fertility enhancing hysteroscopy. Singapore: Springer; 2018. [DOI:10.1007/978-981-10-8028-9_12] [PMCID]
6. Levine LD. Cervical ripening: Why we do what we do. Semin Perinatol 2020; 44: 151216. [DOI:10.1016/j.semperi.2019.151216] [PMID]
7. De Silva PM, Wilson L, Carnegy A, Smith PP, Clark TJ. Cervical dilatation and preparation prior to outpatient hysteroscopy: A systematic review and meta-analysis. BJOG 2021; 128: 1112-1123. [DOI:10.1111/1471-0528.16604] [PMID]
8. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Williams Obstetrics. 25th Ed. New York: McGraw Hill Education; 2014.
9. Choo SN, Kanneganti A, Abdul Aziz MNDB, Loh L, Hargreaves C, Gopal V, et al. Mechanical Dilatation of the cervix in a scarred uterus (MEDICS): The study protocol of a randomised controlled trial comparing a single cervical catheter balloon and prostaglandin PGE2 for cervical ripening and labour induction following caesarean delivery. BMJ Open 2019; 9: e028896. [DOI:10.1136/bmjopen-2019-028896] [PMID] [PMCID]
10. Rund NMA, El Shenoufy H, Islam BA, El Husseiny T, Nassar SA, Mohsen RA, et al. Determining the optimal time interval between vaginal dinoprostone administration and diagnostic office hysteroscopy in nulliparous women: A randomized, double-blind trial. J Minim Invasive Gynecol 2022; 29: 85-93. [DOI:10.1016/j.jmig.2021.06.021] [PMID]
11. Handa VL, Van Le L. Te Linde's operative gynecology. 12th Ed. Philadelphia: Lippincott Williams and Wilkins; 2020: 255-273.
12. Munro MG, Parker WH. Gynecologic Endoscopy. In: Berek JS. Berek & Novak's gynecology. 16th Ed. Philadelphia: Lippincott Williams and Wilkins; 2019: 595-653.
13. Campo R, Santangelo F, Gordts S, Di Cesare C, Van Kerrebroeck H, De Angelis MC, et al. Outpatient hysteroscopy. Facts Views Visn ObGyn 2018; 10: 115-122.
14. Hagen N, Khuluza F, Heide L. Quality, availability and storage conditions of oxytocin and misoprostol in Malawi. BMC Pregnancy Childbirth 2020; 20: 184. [DOI:10.1186/s12884-020-2810-9] [PMID] [PMCID]
15. Nakano FY, Yela DA, Pinto JPL, Riegas T, Benetti-Pinto CL, Pedro AO, et al. Efficacy of misoprostol before diagnostic hysteroscopy in menopausal women: A randomized clinical trial. Menopause 2018; 25: 789-794. [DOI:10.1097/GME.0000000000001074] [PMID]
16. Timoszuk M, Bielawska K, Skrzydlewska E. Evening primrose (Oenothera biennis) biological activity dependent on chemical composition. Antioxidants 2018; 7: 108. [DOI:10.3390/antiox7080108] [PMID] [PMCID]
17. Nikoomazhab S, Haghdoust MR, Honarmandpour A. [The effect of evening primrose oil on duration of postpartum blues among primiparous women: A double-blind, randomized controlled clinical trial]. Iran J Obstet Gynecol Infertil 2017; 20: 64-73. (in Persian)
18. Mahady GB, Fong HHS, Farnsworth NR. Botanical dietary supplements. 1st Ed. USA: CRC Press; 2001.
19. Lee SM, Kim HS, Park HJ, Oh KY, Kim JY, Lee SH, et al. Comparison of antioxidant properties of evening primrose seeds by different processing methods, and physiological properties of evening primrose seed powder. Prev Nutr Food Sci 2020; 25: 422-431. [DOI:10.3746/pnf.2020.25.4.422] [PMID] [PMCID]
20. Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, et al. Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 2020; 10: 818. [DOI:10.3390/biom10060818] [PMID] [PMCID]
21. Pan F, Li Y, Luo X, Wang X, Wang C, Wen B, et al. Effect of the chemical refining process on composition and oxidative stability of evening primrose oil. J Food Proc Preserv 2020; 44: e14800. [DOI:10.1111/jfpp.14800]
22. Freitas HR, Isaac AR, Malcher-Lopes R, Diaz BL, Trevenzoli IH, de Melo Reis RA. Polyunsaturated fatty acids and endocannabinoids in health and disease. Nutr Neurosci 2018; 21: 695-714. [DOI:10.1080/1028415X.2017.1347373] [PMID]
23. Diansuy NN, Aguilar AS. The effectiveness of evening primrose oil gel capsule as a cervical ripening agent during labor induction as measured by bishop score on term singleton pregnant patients. Philippine J Obstet Gynecol 2017; 41: 1-4.
24. Moradi M, Niazi A, Heydarian Miri H, Lopez V. The effect of evening primrose oil on labor induction and cervical ripening: A systematic review and meta‐analysis. Phytother Res 2021; 35: 5374-5383. [DOI:10.1002/ptr.7147] [PMID]
25. 25 Bahmani S, Hesamy K, Shahgheibi S, Roshani D, Shahoei R. Comparison of the effect of vaginal capsule of evening primrose oil and misoprostol on cervical ripening of nulliparous women with post-term pregnancy. J Pharmaceutical Res Int 2019; 26: 47396. [DOI:10.9734/jpri/2019/v26i330140]
26. Kalati M, Kashanian M, Jahdi F, Naseri M, Haghani H, Sheikhansari N. Evening primrose oil and labour, is it effective? A randomised clinical trial. J Obstet Gynaecol 2018; 38: 488-492. [DOI:10.1080/01443615.2017.1386165] [PMID]
27. Tanchoco ML, Aguilar AS. Cervical priming prior to operative hysteroscopy: A randomized controlled study comparing the efficacy of laminaria versus evening primrose oil (EPO). J Minim Invasive Gynecol 2015; 22: S45. [DOI:10.1016/j.jmig.2015.08.122] [PMID]
28. Vahdat M, Tahermanesh K, Mehdizadeh Kashi A, Ashouri M, Solaymani Dodaran M, Kashanian M, et al. Evening primrose oil effect on the ease of cervical ripening and dilatation before operative hysteroscopy. Thrita 2015; 4: e29876. [DOI:10.5812/thrita.29876]
29. Nouri B, Baghestani AR, Pooransari P. Evening primrose versus misoprostol for cervical dilatation before gynecologic surgeries: A double-blind randomized clinical trial. J Obstet Gynecol Cancer Res 2021; 6: 87-94. [DOI:10.30699/jogcr.6.2.87]
30. Mahboubi M. Evening primrose (Oenothera biennis) oil in management of female ailments. J Menopausal Med 2019; 25: 74-82. [DOI:10.6118/jmm.18190] [PMID] [PMCID]
31. Maddineshat M, Keyvanloo S, Lashkardoost H, Arki M, Tabatabaeichehr M. Effectiveness of group cognitive-behavioral therapy on symptoms of premenstrual syndrome (PMS). Iran J Psychiatry 2016; 11: 30-36.
32. Zand Vakili F, Zare SH, Rahimi K, Riahi M. [The effect of evening primrose oil on changes in polycystic ovary syndrome induced by estradiol valerate in Rat]. Armaghane Danesh 2018; 22: 714-724. (in Persian)
33. 33 Faghani Aghoozi M, Fayazi S, Mohammadi S, Tehranian N, Amerian M. The effects of evening primerose on clinical obstetrics of Iran: A review study. Sci J Nurs Midwifery Paramed Faculty 2019; 5: 15-28.
34. Tanchoco M, Aguilar AS. Cervical priming prior to operative hysteroscopy: A randomized controlled study comparing the efficacy of laminaria versus evening primrose oil (EPO). J Minim Invasive Gynecol 2015; 22: S45. [DOI:10.1016/j.jmig.2015.08.122] [PMID]
35. Carreon GA, Tanangonan GG. Cervical priming prior to operative hystroscopy: A randomized clinical trial comparing evening primrose oil versus dinoprostone gel. J Menopausal Med 2012; 9: 74-81.
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