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Reproductive Biomedicine
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Volume 10, Issue 3 (7-2012)
IJRM 2012, 10(3): 201-208 |
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Safdarian L, Khayatzadeh Z, Djavadi E, Mahdavi A, Aghahosseini M, Aleyasin A, et al . Prediction of assisted reproductive technique outcome in elevated early follicular phase follicle stimulating hormone with Mullerian inhibiting substance level. IJRM 2012; 10 (3) :201-208
URL: http://ijrm.ir/article-1-286-en.html
URL: http://ijrm.ir/article-1-286-en.html
Leili Safdarian1 
, Zahra Khayatzadeh1 , Ebrahim Djavadi1 , Atossa Mahdavi * 2, Marzieh Aghahosseini1 , Ashraf Aleyasin1 , Parvin Fallahi1 , Sima Khayatzadeh1 , Arash Ahmadzadeh1 , Mohhamad Bagher Larijani1
, Zahra Khayatzadeh1 , Ebrahim Djavadi1 , Atossa Mahdavi * 2, Marzieh Aghahosseini1 , Ashraf Aleyasin1 , Parvin Fallahi1 , Sima Khayatzadeh1 , Arash Ahmadzadeh1 , Mohhamad Bagher Larijani1
1- Department of Obstetrics, Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics, Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran ,atossa_mahdavi@yahoo.com
2- Department of Obstetrics, Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (4941 Views)
Background: Detection of best predictor of ovarian reserve in patients with temporarily or consistently elevated early follicular phase serum levels of FSH is one of the most important goals in assisted reproductive technique (ART).
Objective: To evaluate whether high level of anti-mullerian hormone level is related to success of ART in patients with temporarily or consistently elevated early follicular phase serum levels of FSH.
Objective: To evaluate whether high level of anti-mullerian hormone level is related to success of ART in patients with temporarily or consistently elevated early follicular phase serum levels of FSH.
Materials and Methods: Sixty three women underwent intracytoplasmic sperm injection (ICSI) with GnRH-agonist long protocol or intrauterine insemination (IUI) in a prospective cohort study. FSH, inhibin B and anti-Mullerian hormone (AMH) levels were measured in these women whom were divided to three groups (persistently elevated FSH, variably elevated FSH and, normal FSH level). Basal characteristics, stimulation parameters, and pregnancy occurrence were evaluated.
Results: AMH was significantly higher in women with persistently elevated early follicular phase FSH achieving pregnancy. Women with normal FSH did not have significant difference in AMH level between conceived and non conceived cycles. Women with only one elevated early follicular phase FSH achieving pregnancy did not have significant difference in AMH level with non pregnant women. Response to gonadotropin stimulation, recommendation to oocyte donation significantly differed between the groups.
Conclusion: This study has demonstrated that relatively young women with persistently or intermittently elevated day 3 FSH levels have diminished ovarian reserve and lower ART success. However, in women whose FSH levels were constantly elevated, AMH (not inhibin B) concentrations were significantly higher in ART cycles resulting in pregnancy. Therefore, AMH level is a good predictor of ART outcome in patients with elevated early follicular phase serum levels of FSH.
Results: AMH was significantly higher in women with persistently elevated early follicular phase FSH achieving pregnancy. Women with normal FSH did not have significant difference in AMH level between conceived and non conceived cycles. Women with only one elevated early follicular phase FSH achieving pregnancy did not have significant difference in AMH level with non pregnant women. Response to gonadotropin stimulation, recommendation to oocyte donation significantly differed between the groups.
Conclusion: This study has demonstrated that relatively young women with persistently or intermittently elevated day 3 FSH levels have diminished ovarian reserve and lower ART success. However, in women whose FSH levels were constantly elevated, AMH (not inhibin B) concentrations were significantly higher in ART cycles resulting in pregnancy. Therefore, AMH level is a good predictor of ART outcome in patients with elevated early follicular phase serum levels of FSH.
Keywords: Anti-mullerian hormone, In-vitro fertilization, Assisted reproductive technique, Inhibin B
Type of Study: Original Article |
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