International Journal of
Reproductive Biomedicine
Wed, Aug 20, 2025
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Volume 23, Issue 5 (May 2025 2025)
IJRM 2025, 23(5): 353-376 |
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Akbari Sene A, Saeedzarandi M, Yazdizadeh M, Ghaffari S R, Amjadi F, Zandieh Z et al . The effect of myo-inositol on assisted reproductive technology outcomes in women with polycystic ovarian syndrome: A systematic review and meta-analysis of randomized clinical trial studies. IJRM 2025; 23 (5) :353-376
URL: http://ijrm.ir/article-1-3318-en.html
URL: http://ijrm.ir/article-1-3318-en.html
Azadeh Akbari Sene1 
, Maryam Saeedzarandi2 , Maryam Yazdizadeh3 , Seyede Razieh Ghaffari2 , Fatemehsadat Amjadi1 , Zahra Zandieh1 , Yousef Moradi *4
, Maryam Saeedzarandi2 , Maryam Yazdizadeh3 , Seyede Razieh Ghaffari2 , Fatemehsadat Amjadi1 , Zahra Zandieh1 , Yousef Moradi *4
1- Shahid Akbar Abadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. & Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.
2- Shahid Akbar Abadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
3- Department of Obstetrics and Gynecology, Medical School, Birjand University of Medical Sciences, Birjand, Iran.
4- Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. ,Yousefmoradi211@yahoo.com
2- Shahid Akbar Abadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
3- Department of Obstetrics and Gynecology, Medical School, Birjand University of Medical Sciences, Birjand, Iran.
4- Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. ,
Abstract: (270 Views)
Background: Conflicting evidence from clinical trials on the effects of myo-inositol and D-chiro-inositol on assisted reproductive technology (ART) outcomes in women with polycystic ovarian syndrome (PCOS) necessitates a systematic review and meta-analysis.
Objective: To evaluate the effect of myo-inositol and D-chiro-inositol on ART outcomes in women with PCOS.
Materials and Methods: A comprehensive search was conducted in PubMed, Scopus, Web of Science, EMBASE, ClinicalTrials.gov, and the Cochrane Library for studies published from January 2000-2023. Statistical analyses were performed using STATA version 17.
Results: 17 intervention studies were included. myo-inositol/D-chiro-inositol supplementation significantly increased the clinical pregnancy rate (RR: 1.64, 95% CI: 1.25-2.15; I² = 13.5%; p = 0.32) and top-grade embryos (RR: 1.12, 95% CI: 1.02-1.23; I² = 85.43%; p = 0.0001). However, it was associated with reductions in antral follicle count (WMD: -0.78, 95% CI: -1.07 to -0.49; I² = 97.37%; p = 0.001) and anti-Mullerian hormone levels (WMD: -0.46, 95% CI: -0.67 to -0.25; I² = 91.95%; p = 0.001).
Conclusion: This meta-analysis provides reliable evidence on the effects of myo-inositol/D-chiro-inositol on fertility and ovarian function in women with PCOS undergoing ART.
Objective: To evaluate the effect of myo-inositol and D-chiro-inositol on ART outcomes in women with PCOS.
Materials and Methods: A comprehensive search was conducted in PubMed, Scopus, Web of Science, EMBASE, ClinicalTrials.gov, and the Cochrane Library for studies published from January 2000-2023. Statistical analyses were performed using STATA version 17.
Results: 17 intervention studies were included. myo-inositol/D-chiro-inositol supplementation significantly increased the clinical pregnancy rate (RR: 1.64, 95% CI: 1.25-2.15; I² = 13.5%; p = 0.32) and top-grade embryos (RR: 1.12, 95% CI: 1.02-1.23; I² = 85.43%; p = 0.0001). However, it was associated with reductions in antral follicle count (WMD: -0.78, 95% CI: -1.07 to -0.49; I² = 97.37%; p = 0.001) and anti-Mullerian hormone levels (WMD: -0.46, 95% CI: -0.67 to -0.25; I² = 91.95%; p = 0.001).
Conclusion: This meta-analysis provides reliable evidence on the effects of myo-inositol/D-chiro-inositol on fertility and ovarian function in women with PCOS undergoing ART.
Keywords: D-chiro-inositol-galactosamine, Inositol, Assisted reproductive techniques, Polycystic ovarian syndrome, Evidence synthesis.
Type of Study: Review Article |
Subject:
Reproductive Biology
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