Volume 11, Issue 11 (12-2013)                   IJRM 2013, 11(11): 891-0 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Dorostghoal M, Seyyednejad S M, Khajehpour L, Jabari A. Effect of Fumaria parviflora leaves extract on reproductive parameters in adult male rats. IJRM 2013; 11 (11) :891-0
URL: http://ijrm.ir/article-1-362-en.html
Effect of Fumaria parviflora leaves extract on reproductive parameters in adult male rats
Mehran Dorostghoal * 1, Seyyed Mansoor Seyyednejad2 , Lotfollah Khajehpour2 , Ayoob Jabari2
1- Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran , mdorostghoal@yahoo.com
2- Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract:   (3248 Views)
Background: There is growing concern that occupational, environmental and lifestyle factors adversely affect male reproductive health. Fumaria parviflora Lam. is being used traditionally in Persian folk medicine to cure various ailments and has been supposed to have fertility-enhancing properties.
Objective: A dose-response study was designed to assess effects of F. parviflora ethanolic leaves extract on reproductive parameters in adult male Wistar rats.
Materials and Methods: In this experimental study, healthy adult male rats were treated with 100, 200 and 400 mg/kg/day of F. parviflora leaves extract via gavage for 70 days. Blood samples were collected for determination of testosterone, LH and FSH serum levels. Reproductive organs weight, motility, morphology and density of epididymal sperm, seminiferous tubules diameter and germinal epithelium height were evaluated in each experimental group. Results: The body weight was not affected, while the weights of testis and epididymis were significantly enhanced in rats treated with 200 and 400 mg/kg/day F. parviflora extract. No significant changes were observed in seminal vesicle and ventral prostate weight between experiment groups. Significant increase was found in epididymal sperm density and percent of morphologically normal sperm in extract-treated rats. Serum testosterone levels were significantly higher in rats received 200 and 400 mg/kg/day.
Conclusion: The results indicated that ethanolic extract of F. parviflora leaves have a potential to improve reproductive parameters and enhance male fertility.
Keywords: Fumaria parviflora Lam., Male fertility, Spermatogenesis, Sperm quality, Testosterone.
Full-Text [PDF 483 kb]   (865 Downloads) |   |   Full-Text (HTML)  (398 Views)  
Type of Study: Original Article |
References
1. Thonneau P, Bujan L, Multigner L, Mieusset R. Occupational heat exposure and male fertility: a review. Hum Reprod 1998; 13: 2122-2125. [DOI:10.1093/humrep/13.8.2122]
2. Lackner J, Schatzl G, Waldhor T, Resch K, Kratzik C, Marberger M. Constant decline in sperm concentration in infertile males in an urban population: Experience over 18 years. Fertil Steril 2005; 84: 1657-1661. [DOI:10.1016/j.fertnstert.2005.05.049]
3. De Celis R, Pedron-Nuevo N, Feria-Velasco A. Toxicology of male reproduction in animals and humans. Arch Androl 1996; 37: 201-218. [DOI:10.3109/01485019608988523]
4. Sharpe RM. Environmental/lifestyle effects on spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 1546: 1697-1712. [DOI:10.1098/rstb.2009.0206]
5. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003; 79: 829-843. [DOI:10.1016/S0015-0282(02)04948-8]
6. Sikka SC. Relative impact of oxidative stress on male reproductive function. Curr Med Chem 2001; 8: 851-862. [DOI:10.2174/0929867013373039]
7. Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol 2006; 18: 325-332. [DOI:10.1097/01.gco.0000193003.58158.4e]
8. Menezo YJ, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online 2007; 14: 418-421. [DOI:10.1016/S1472-6483(10)60887-5]
9. D'Cruz SC, Vaithinathan S, Jubendradass R, Mathur PP. Effects of plants and plant products on the testis. Asian J Androl 2010; 12: 468-479. [DOI:10.1038/aja.2010.43]
10. Amin GH. Popular Medical Plants of Iran. Farhang Publication, Tehran; 1991: 51-52.
11. Zargari A. Medicinal Plants. Tehran University Publication, Tehran; 1989: 170-171.
12. Barimani L. Traditional medicine traditional drugs. Gutenberg Publication, Tehran; 1982: 335-336.
13. Heydari Nasrabadi M, Aboutalebi H, Naseri M. Effect of Fumaria parviflora alcoholic extract on male rat reproductive system. J Med Plants Res 2012; 10: 2004-2010.
14. Orhan IE, Sener B, Musharraf SG. Antioxidant and hepatoprotective activity appraisal of four selected Fumaria species and their total phenol and flavonoid quantities. Exp Toxicol Pathol 2012; 64: 205-209. [DOI:10.1016/j.etp.2010.08.007]
15. Rao CV, Verma AR, Gupta PK, Vijayakumar M. Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. Acta Pharm 2007; 57: 491-498. [DOI:10.2478/v10007-007-0039-z]
16. Githiori JB, Athanasiadou S, Thamsborg SM. Use of plants in novel approaches for control of gastrointestinal helminths in livestock with emphasis on small ruminants. Vet Parasitol 2006; 139: 308-320. [DOI:10.1016/j.vetpar.2006.04.021]
17. Khattak SG, Gilani SN, Ikram M. Antipyretic studies on some indigenous Pakistani medicinal plants. J Ethnopharmacol 1985; 14: 45-51. [DOI:10.1016/0378-8741(85)90027-3]
18. Baser KHC, Honda G, Miki W. Herb drugs and herbalists in Turkey. Studia Culturae Islamica No. 27, Tokyo; 1986: 299.
19. Suau R, Cabezudo B, Rico R, Najera F, Lopez-Romero JM. Direct determination of alkaloid contents in Fumaria species by GC-MS. Phytochem Anal 2002; 13: 363-367. [DOI:10.1002/pca.669]
20. Jamshidzadeh A, Niknahad H. Hepatoprotective effects of Fumaria Parviflora on CCL4-induced hepatotoxicity. J Med Plants 2006; 19: 34-39.
21. Mortazavi SR, Nassiri-Asl M, Farahani-Nick Z, Savad S, Farzam SK. Protective effects of Fumaria vaillantii extract on carbon tetrachloride-induced heaptotoxicity in rats. Pharmacol Online 2007; 3: 385-393.
22. Gilani AH, Janbas KH, Akhtar MS. Selective effect of an extract from Fumaria parviflora on paracetamol-induced hepatotoxicity. Gen Pharmacol 1996; 27: 979-983. [DOI:10.1016/0306-3623(95)02140-X]
23. Adewusi EA, Afolayan AJ. A review of natural products with hepatoprotective activity. J Med Plants Res 2010; 4: 1318-1334.
24. Soušek J, Vavrecková C, Psotová J, Ulrichová J, Šimánek V. Antioxidant and antilipoperoxidant activities of alkaloid and phenolic extracts of eight Fumaria species. Acta Hort 1999; 501: 239-244.
25. Rehman N, Mehmood MH, Al-Rehaily AJ, Mothana RAA, Gilani AH. Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora. BMC Complement Altern Med 2012; 12:16.
26. Fathiazad F, Hamedeyazdan S, Khosropanah MK, Khaki A. Hypoglycemic activity of Fumaria parviflora in streptozotocin-induced diabetic rats. Adv Pharmaceut Bull 2013; 3: 207-210.
27. Heidari MR, Mandgary A, Enayati M. Antinociceptive effects and toxicity of Fumaria parviflora lam. in mice and rats. Daru 2004; 12: 136-140.
28. Jowkar F, Jamshidzadeh A, Mirzadeh Yazdi A, Pasalar M. The effects of Fumaria Parviflora extract on chronic hand eczema: A randomized double-blind placebo controlled clinical trial. Iran Red Crescent Med J 2011; 11: 824-828.
29. Arzi A, Nazari Z, Ahmadi Salianeh SV. Study of the effect of hydro-alcoholic extract of Fumaria Parviflora on carageenan induced inflammation in male rat paw. Jentashapir 2013, 4: 121-130.
30. Venkateswara Rao C, Verma AR, Gupta PK, Vijayakumar M. Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. Acta Pharm 2007; 57: 491-498.
31. Franca LR, Godinho CL. Testis morphometry, seminiferous epithelium cycle length and daily sperm production in domestic cats (Felis catus). Biol Reprod 2003; 68: 1554-1561. [DOI:10.1095/biolreprod.102.010652]
32. Seed J, Chapin RE, Clegg ED, Dostal LA, Foote RH, Hurtt ME, et al. Methods for assessing sperm motility, morphology and counts in the rat, rabbit and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation. Reprod Toxicol 1996; 10: 237-244. [DOI:10.1016/0890-6238(96)00028-7]
33. Hayes W. Principle and Methods of Toxicology. Raven Press, New York; 1989: 929.
34. Mann T. Secretory function of the prostate, seminal vesicle, and other male accessory organs of testis. Andrologia 1974; 52: 12-17.
35. Prins SG, Birch L, Greene GL. Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology 1991; 129: 3187-3199. [DOI:10.1210/endo-129-6-3187]
36. Chandra AK, Ghosh R, Chatterjee A, Sarkar M. Effects of vanadate on male rat reproductive tract histology, oxidative stress markers and androgenic enzyme activities. J Inorg Biochem 2007; 101: 944-956. [DOI:10.1016/j.jinorgbio.2007.03.003]
37. Raji Y, Udoh US, Mewoyaka OO, Ononye FC, Bolarinwa AF. Implication of reproductive endocrine malfunction in male antifertility efficacy of Azadirachta indica extract in rats. Afr J Med Med Sci 2003; 32: 159-165.
38. Agarwal A, Ikemoto I, Loughlin KR. Relationship of sperm parameters to levels of reactive oxygen species in semen specimens. J Urol 1994; 152: 107-110. [DOI:10.1016/S0022-5347(17)32829-X]
39. Naz I, Palomares-Rius JE, Blok SV, Khan MR, Ali S, Ali S. In vitro and in planta nematicidal activity of Fumaria parviflora (Fumariaceae) against the southern root-knot nematode Meloidogyne incognita. Plant Pathol 2013; 62: 943-952. [DOI:10.1111/j.1365-3059.2012.02682.x]
40. Orhan IE, Sener B, Musharraf SG. Antioxidant and hepatoprotective activity appraisal of four selected Fumaria species and their total phenol and flavonoid quantities. Exp Toxicol Pathol 2010; 64: 205-209. [DOI:10.1016/j.etp.2010.08.007]
41. Sousek J, Vavreckova C, Psotova J, Ulrichova J, Simanek V. Antioxidant and antilipoperoxidant activities of alkaloid and phenolic extracts of eight Fumaria species. Acta Hort 1999; 501: 239-244.
42. Madani H, Talebolhosseiny M, Asgari S, Mahzooni P, Razban E. Preventive effect of hydroalcoholic extract of Silybum marianum and Fumaria vaillantii in atherosclerosis. Pharm Sci 2007; 4: 29-34.
43. Khalighi-Sigaroodi F, Yazdani D, Taghizadeh M, Rezazadeh Sh. Quantitative determination of an effective component of Fumaria parviflora lam. J Med Plants 2005; 41: 62-71.
44. Rao KS, Mishra SH. Anti-hepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J Ethno Phamacol 1998; 60: 207-213. [DOI:10.1016/S0378-8741(97)00149-9]
45. Jung KA, Kwalk MK. The Nrf2 system as a potantial target for the development of indirect antioxidants. Molecules 2010; 10: 7266-7291. [DOI:10.3390/molecules15107266]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb