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Reproductive Biomedicine
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Volume 11, Issue 12 (1-2013)
IJRM 2013, 11(12): 999-0 |
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Nasri K, Chehrei A, Manavi M S. Evaluation of vaginal group B streptococcal culture results after digital vaginal examination and its pattern of antibiotic resistance in pregnant women. IJRM 2013; 11 (12) :999-0
URL: http://ijrm.ir/article-1-374-en.html
URL: http://ijrm.ir/article-1-374-en.html
1- Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran , khdrnasri2@gmail.com
2- Department of Pathology, Thyroid Research Center, Arak University of Medical Sciences, Arak, Iran
3- Arak University of Medical Sciences, Arak, Iran
2- Department of Pathology, Thyroid Research Center, Arak University of Medical Sciences, Arak, Iran
3- Arak University of Medical Sciences, Arak, Iran
Abstract: (2686 Views)
Background: Group B streptococcus (GBS) colonizes the gastrointestinal and genitourinary tract of 10-40% of pregnant women and it is a major cause of neonatal morbidity and mortality.
Objective: This study was to evaluate whether vaginal GBS culture results alter after digital vaginal examination or not. Antibiotic resistance pattern of this specie has been also assessed.
Materials and Methods: A total of 186 pregnant women with gestational age of 37 weeks were enrolled to the study. Two vaginal swaps were taken before and immediately after digital vaginal examination, then third swap was taken after 48 hours of examination. The cultures were evaluated for bacterial growth and the isolated bacteria were assessed for antimicrobial drugs sensitivity.
Results: Positive culture of GBS was seen in 16.1%. Initially negative GBS result was found not to change immediately after examination. But positive cultures were negative in 1.6% of women after digital vaginal examination. After 48 hours 2.7% of initially negative GBS was positive and no one with initially positive GBS had negative culture. Sensitivity to penicillin and vancomycin was 100%, erythromycin 74%, ampicillin 65%, cefazolin 62.8%, cefotaxime 54.2% and ceftizoxime was 40%.
Conclusion: The present investigation showed that the vaginal GBS culture result is minimally affected by digital vaginal examination. Drug of choice for GBS eradication is penicillin; vancomycin could be the choice in the case of penicillin hypersensitivity.
Objective: This study was to evaluate whether vaginal GBS culture results alter after digital vaginal examination or not. Antibiotic resistance pattern of this specie has been also assessed.
Materials and Methods: A total of 186 pregnant women with gestational age of 37 weeks were enrolled to the study. Two vaginal swaps were taken before and immediately after digital vaginal examination, then third swap was taken after 48 hours of examination. The cultures were evaluated for bacterial growth and the isolated bacteria were assessed for antimicrobial drugs sensitivity.
Results: Positive culture of GBS was seen in 16.1%. Initially negative GBS result was found not to change immediately after examination. But positive cultures were negative in 1.6% of women after digital vaginal examination. After 48 hours 2.7% of initially negative GBS was positive and no one with initially positive GBS had negative culture. Sensitivity to penicillin and vancomycin was 100%, erythromycin 74%, ampicillin 65%, cefazolin 62.8%, cefotaxime 54.2% and ceftizoxime was 40%.
Conclusion: The present investigation showed that the vaginal GBS culture result is minimally affected by digital vaginal examination. Drug of choice for GBS eradication is penicillin; vancomycin could be the choice in the case of penicillin hypersensitivity.
Type of Study: Original Article |
References
1. Shahbazian N, Rajabzadeh A, Alavi SM. [Vaginal and Rectal colonization of GBS in Pregnant woman 35-37 weeks gestationand pattern of Antibiotic restance]. Sci Med J Ahwaz Jundishapur Univ Med Sci 2007; 6: 294-298. (In Persian)
2. Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recom Rep 2002; 51: 1-22.
3. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Williams Obstetrics. 23th Ed. Mc GrowHill, New York; 2010: 1220-1223.
4. Brady K, Sizemore KL, Duff P, Aamodt LW. The effect of bacteriostatic lubricant on group B streptococcal cultures of the female genital tract. Obstet Gynecol 1989; 74: 848-850.
5. Amirmozafari N, Mansour Ghanei M, Sadr Nouri B, Farhadi Tooli L. [Survey Prevalence of Group B Streptococci in Genital Tract Women in 28-37 Weeks Pregnancy]. J Guilan Univ Med Sci 2006; 15: 91-96. (In Persian)
6. Habibzade SH, Arzanlou M, Jannati E, Asmar M, Azari M, Fardiazar Z. [Maternal Carriage of Group B Streptococcus in Ardabil, Prevalence and Antimicrobial Resistance]. J Ardabil Univ Med Sci 2010; 10: 14-20. (In Persian)
7. Javadi N, Khorvash B, Tabibian M, Narimani A. [Vaginal Colonization of GBS in pregnant women in 35-37 weeks gestation]. J Isfahan Univ Med Sci 2004; 22: 89-94. (In Persian)
8. Knudtson EJ, Lorenz LB, Skaggs VJ, Peck JD, Goodman JR, Elimian AA. The effect of digital cervical examination on group B streptococcal culture. Am J Obstet Gynecol 2010; 202: 1-4. [DOI:10.1016/j.ajog.2009.08.021]
9. Schwope OI, Chen KT, Mehta I, Re M, Rand L. The effect of a chlorhexidine-based surgical lubricant during pelvic examination on the detection of group B Streptococcus. Am J Obstet Gynecol 2010; 202: 1-3. [DOI:10.1016/j.ajog.2009.10.860]
10. Palwlik M, Martin FJ. Does a water-based lubricant affect Pap smear and cervical microbiology results? Can Fam Physician 2009; 55: 376-377.
11. Zusman AS, Baltimore RS, Fonseca SN. Prevalence of maternal group B streptococcal colonization and related risk factors in a Brazilian population. Braz J Infect Dis 2006; 10: 242-246. [DOI:10.1590/S1413-86702006000400005]
12. Piper JM, Georgiou S, Xenakis EM, Langer O. Group B streptococcus infection rate unchanged by gestational diabetes. Obstet Gynecol 1999; 93: 292-296.
13. Stapleton RD, Kahn JM, Evans LE, Critchlow CW, Gardella CM. Risk factors for group B streptococcal genitourinary tract colonization in pregnant women. Obstet Gynecol 2005; 106: 1246-1252. [DOI:10.1097/01.AOG.0000187893.52488.4b]
14. Nakhaei Moghaddam. Recto-Vaginal colonization of group B streotococcus in pregnant women referred to a Hospital in Iran and its effect on lactobacillus normal flora. J Biol Sci 2010; 10: 166-169. [DOI:10.3923/jbs.2010.166.169]
15. Matorras R, Garcia-Perea A, Usandizaga JA, Omenaca F. Recto-vaginal colonization and urinary tract infection by group B Streptococcus in the pregnant diabetic patient. Acta Obstet Gynecol Scand 1988; 67: 617-620. [DOI:10.3109/00016348809004274]
16. Daugaard HO, Thomsen AC, Henriques U, Ostergaard A. Group B streptococci in the lower 1. Shahbazian N, Rajabzadeh A, Alavi SM. [Vaginal and Rectal colonization of GBS in Pregnant woman 35-37 weeks gestationand pattern of Antibiotic restance]. Sci Med J Ahwaz Jundishapur Univ Med Sci 2007; 6: 294-298. (In Persian)
17. Terry RR, Kelly FW, Gauzer C, Jeitler M. Risk factors for maternal colonization with group B beta-hemolytic streptococci. J Am Osteopath Assoc 1999; 99: 571-573. [DOI:10.7556/jaoa.1999.99.11.571]
18. Regan JA, Klebanoff MA, Nugent RP. The epidemiology of group B streptococcal colonization in pregnancy. Vaginal Infections and Prematurity Study Group. Obstet Gynecol 1991; 77: 604-610.
19. Simoes JA, Aroutcheva AA, Heimler I, Faro S. Antibiotic Resistance in Invasive Group B Streptococcal Isolates. Infect Dis Obstet Gynecol 2004; 12: 1-8. [DOI:10.1080/10647440410001722269]
20. Chohan L, Hollier LM, Bishop K, Kilpatrick CC. Patterns of antibiotic resistance among group B streptococcus isolates: 2001-2004. Infect Dis Obstet Gynecol 2006; 2006: 57492. [DOI:10.1155/IDOG/2006/57492]
21. Al-Sweih N, Jamal M, Kurdia M, Abduljabar R, Rotimi V. Antibiotic susceptibility profile of group B streptococcus (Streptococcus agalactiae) at the Maternity Hospital, Kuwait. Med Princ Pract 2005; 14: 260-263. [DOI:10.1159/000085746]
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