Volume 11, Issue 5 (7-2013)                   IJRM 2013, 11(5): 385-0 | Back to browse issues page

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Sharami S H, Faraji Darkhaneh R, Zahiri Z, Milani F, Asgharnia M, Shakiba M et al . The relationship between vaginal bleeding in the first and second trimester of pregnancy and preterm labor. IJRM 2013; 11 (5) :385-0
URL: http://ijrm.ir/article-1-421-en.html
The relationship between vaginal bleeding in the first and second trimester of pregnancy and preterm labor
Seyedeh Hajar Sharami1 , Roya Faraji Darkhaneh * 2, Ziba Zahiri1 , Forozan Milani1 , Maryam Asgharnia1 , Maryam Shakiba3 , Zirak Didar3
1- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran
2- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran , royafaraji1371@yahoo.com
3- Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (2896 Views)
Background: Vaginal bleeding is a common complication during pregnancy, which is observed in about 1/4 of pregnancies and in half of cases can lead to abortion. If vaginal bleeding happens during pregnancy some adverse pregnancy outcomes, including perinatal mortality and morbidity, low birth weight and preterm delivery will be increased.
Objective:  The aim of this study was to determine the relationship between vaginal bleeding and its characteristics in the first and second trimester of pregnancy and preterm labor.
Materials and Methods:  This is a case-control study conducted on 440 pregnant women referred to Al-Zahra Hospital in Rasht, Iran. Data were collected by a form. The form included demographic characteristics and confounding factors, the occurrence of bleeding during pregnancy and its features. Data were analyzed by T test, chi square and logistic regression in SPSS 16.
Results:  Findings showed that vaginal bleeding was associated with 3 times increased risk of preterm delivery (OR: 3, 1.84-4.89). Also, findings showed that bleeding characteristics including bleeding time, frequency, severity and intensity was significantly associated with preterm labor.
Conclusion:  According to significant association between vaginal bleeding and preterm delivery, it seems that performing some interventions to prevent preterm labor could be appropriate.
Keywords: Pregnancy, Preterm labor, Vaginal bleeding
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Type of Study: Original Article |
References
1. Hossain R, Harris T, Lohsoonthorn V, Williams MA. Risk of preterm delivery in relation to vaginal bleeding in early pregnancy. Eur J Obstet Gynecol Reprod Biol 2007; 135: 158-163. [DOI:10.1016/j.ejogrb.2006.12.003]
2. Mattison DR, Damus K, Fiore E, Petrini J, Alter C. Preterm delivery: a public health perspective. Paediatr Perinat Epidemiol 2001; 15 (Suppl.): 7-16. [DOI:10.1046/j.1365-3016.2001.00004.x]
3. Axelsen SM, Henriksen TB, Hedegaard M, Secher NJ. Characteristics of vaginal bleeding during pregnancy. Eur J Obstet Gynecol Reprod Biol 1995; 63: 131-134. [DOI:10.1016/0301-2115(95)02236-8]
4. Yang J, Hartmann KE, Savitz DA, Herring AH, Dole N, Olshan AF, et al. Vaginal bleeding during pregnancy and preterm birth. Am J Epidemiol 2004: 160: 118-125. [DOI:10.1093/aje/kwh180]
5. Weiss JL, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, et al. Threatened abortion: A risk factor for poor pregnancy outcome, a population-based screening study. Am J Obstet Gynecol 2004; 190: 745-750. [DOI:10.1016/j.ajog.2003.09.023]
6. Elovitz MA, Baron J, Phillipe M. The role of thrombin in preterm parturition. AM J Obstet Gynecol 2001; 185: 1059-1063. [DOI:10.1067/mob.2001.117638]
7. Rosen T, Kuczynski E, O'Neill LM, Funai EF, Lockwood CJ. Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes. J Matern Fetal Med 2001; 10: 297-300. [DOI:10.1080/jmf.10.5.297.300]
8. Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya S. Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review. BJOG 2010; 117: 245-257. [DOI:10.1111/j.1471-0528.2009.02427.x]
9. Strobino B, Pantel-Silverman J. Gestational vaginal bleeding and pregnancy outcome. Am J Epidemiol 1989; 129: 806-815. [DOI:10.1093/oxfordjournals.aje.a115195]
10. Sun L, Tao F, Hao J, Su P, Liu F, Xu R. First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China. J Matern Fetal Neonatal Med 2012; 25: 1297-1301. [DOI:10.3109/14767058.2011.632034]
11. Chung TK, Sahota DS, Lau TK, Mongelli JM, Spencer JA, Haines CJ. Threatened abortion: prediction of viability based on signs and symptoms. Aust N Z J Obstet Gynaecol 1999; 39: 443-447. [DOI:10.1111/j.1479-828X.1999.tb03129.x]
12. Lykke JA, Dideriksen KL, Lidegaard O, Langhoff-Roos J. First-trimester vaginal bleeding and complications later in pregnancy. Obstet Gynecol 2010; 115: 935-944. [DOI:10.1097/AOG.0b013e3181da8d38]
13. Yoneyama K, Kimura A, Kogo M, Kiuchi Y, Morimoto T, Okai T. Clinical predictive factors for preterm birth in women with threatened preterm labour or preterm premature ruptured membranes? Aust N Z J Obstet Gynaecol 2009; 49: 16-21. [DOI:10.1111/j.1479-828X.2008.00930.x]
14. Karim SA, Bakhtawar I, Butta AT, Jalil M. Effects of first and second trimester vaginal bleeding on pregnancy outcome. J Pak Med Assoc 1998; 48: 40-42.
15. Jouppila P. Vaginal bleeding in the last two trimesters of pregnancy. A clinical and ultrasonic study. Acta Obstet Gynecol Scand 1979; 58: 461-467. [DOI:10.3109/00016347909154068]
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