دوره 11، شماره 8 - ( 8-1392 )                   جلد 11 شماره 8 صفحات 0-637 | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Oremosu A A, Akang E N, Adigwe C C, Okoko I E, Azu O O. Post-treatment with Telfairia occidentalis seed oil attenuates alcohol-induced testicular damage in Sprague-Dawley rats. IJRM 2013; 11 (8) :637-0
URL: http://ijrm.ir/article-1-454-fa.html
درمان با روغن دانه Telfairia occidentalis باعث کاهش آسیب  های ایجاد شده به وسیله الکل در بیضه رت های Sprague-Dawley می شود . International Journal of Reproductive BioMedicine. 1392; 11 (8) :637-0

URL: http://ijrm.ir/article-1-454-fa.html

درمان با روغن دانه Telfairia occidentalis باعث کاهش آسیب  های ایجاد شده به وسیله الکل در بیضه رت های Sprague-Dawley می شود 
چکیده:   (2855 مشاهده)
مقدمه: گزارش شده که استفاده طولانی مدت الکل باعث اختلالات جنسی در مردان از جمله کاهش میزان تستوسترون و همچنین تغییرات مرفولوژی بیضه می­شود.
هدف: هدف از انجام این تحقیق بررسی توانایی Telfairia occidentalis (T.O.) در بهبود اثرات الکل بر روی پارامترهای بیضه بود.
مواد و روش­ها: رت­های Sprague- Dawley نر به 6 گروه تقسیم شدند. گروه کنترل+ آب مقطر برای 8 هفته آب مقطر، گروه کنترل- برای 2 هفته اتانول و سپس 6 هفته آب مقطر دریافت کردند. گروه دیگر برای 2 هفته اتانول و گروه بعدی 2 هفته اتانول و سپس برای 6 هفته mg/kg 600 و 400، 200 T.O. دریافت کردند.
نتایج: اتانول باعث کاهش واضح ژرم سل­های بیضه بعد از 2 هفته شد. T.O. در مقایسه با گروه کنترل در روز mg/kg 200 اثر مشخصی نداشت اما در روز mg/kg 400 T.O. با برگرداندن اثرات اتانول باعث افزایش تعداد و حرکت اسپرم، تستوسترون سرم و وزن بیضه شد. در نهایت در روز mg/kg 600 کاهش ژرم سل­های بیضه و یک کاهش در پارامترهای سمن و وزن بیضه مشاهده شد.
نتیجه­گیری: این مطالعه نشان داد که T.O. باعث تحریک بازسازی ژرم سل­های بیضه و بهبود کیفیت سمن در یک روز مشخص شده و همچنین T.O. توانایی برگشت دادن آسیب­های بیضه بر اثر اتانول را دارد. 
واژه‌های کلیدی: Telfairia occidentalis، بیضه، سمیت اتانول، تعداد اسپرم، پس از درمان.
متن کامل مقاله [PDF 557 kb]   (715 دریافت)    
نوع مطالعه: Original Article |
فهرست منابع
1. Kumar R, Venkatesh S, Kumar M, Tanwar M, Shasmsi MB, Kumar R, et al. Oxidative stress and sperm mitochondrial DNA mutation in idiopathic oligoasthenozoospermic men. Indian J Biochem Biophys 2009; 46: 172-177.
2. Saalu LC, Osinubi AA. Environmental Endocrine Disruptors of Testicular Function. Afr J Endocrinol Metabol 2009; 8: 13-23.
3. Sharlip ID, Jarow JP, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, et al. Best practice policies for male infertility. Fertil Steril 2002; 77: 873-882. [DOI:10.1016/S0015-0282(02)03105-9]
4. Onyeka CA, Ashiru OA, Duru FI, Olurunfemi OJ, Fabunmi OO, Oluwatuyi TS. Semen analysis of 263 sample men from infertility clinic in Western Nigeria. Available at: http://wajar.info/archive.html.
5. Okonofua F, Menakaya U, Onemu SO, Omo-Aghoja LO, Bergstrom S. A case-control study of risk factors for male infertility in Nigeria. Asian J Androl 2005; 7: 351-361. [DOI:10.1111/j.1745-7262.2005.00046.x]
6. Agarwal A, Sharma RK, Nallella KP, Thomas AJ Jr, Alvarez JG, Sikka SC. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 2006; 86: 878-885. [DOI:10.1016/j.fertnstert.2006.02.111]
7. Little PJ, Adams ML, Cicero TJ. Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the developing male rat. J Phamacol Exp Ther 1992; 263: 1056-1061.
8. Emanuele M, Emanuele N. Alcohol and male reproductive system. Alcohol Res Health 2001; 25: 282-287.
9. Taati M, Alirezaei M, Meshkatalsadat MH, Rasoulian B, Kheradmand A, Neamati Sh. Antioxidant effects of aqueous fruit extract of Ziziphus jujuba on ethanol-induced oxidative stress in the rat testes. Iran J Vet Res Shiraz Univ 2011; 12: 39-45.
10. Dosumu OO, Akinola BO, Akang EN. Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats- The therapeutic potential of virgin coconut oil. Mid East Fertil Soc J 2012; 17: 122-128. [DOI:10.1016/j.mefs.2011.12.005]
11. Kayode AAA, Kayode OT. Some Medicinal Values of Telfairia occidentalis: A Review. Am J Biochem Mol Biol 2011; 1: 30-38. [DOI:10.3923/ajbmb.2011.30.38]
12. Odoemena CS, Onyeneke EC. Lipids of fluted pumpkin (Telfairia occidentalis) seeds. Proceedings of the 1st African Conference on Biochemistry of Lipids, (ACBL'98), Ambik Press, Benin City, Nigeria; 1998: 147-151.
13. Oluwole FS, Falode AO, Ogundipe OO. Anti-inflammatory effect of some common Nigeria vegetables. Nig J Physiol Sci 2003; 18: 35-38.
14. Nkang A, Omokaro D, Egbe A, Amanke G. Variations in fatty acid proportions during desiccation of Telfairia occidentalis seeds harvested at physiological and agronomic maturity. Afr J Biotechnol 2003; 2: 33-39. [DOI:10.5897/AJB2003.000-1006]
15. AderIbigbe AO, Lawal BAS, Oluwagbemi JO. The antihyperglycaemic effect of Telfairia occidentalis in mice. Afr J Med Med Sci 1999; 28: 171-175.
16. Alada ARA. The haematological effects of Telfairia occidentalis diet preparation. Afr J Biomed Res 2000; 3: 185-186.
17. Dina OA, Adedapo AA, Oyinloye OP, Saba AB. Effect of Telfairia occidentalis extract on experimentally induced anaemia in domestic. Afr J Biomed Res 2000; 3: 181-183.
18. Salman TM, Olayaki LA, Oyeyemi WA. Aqueous extract of Telfairia occidentalis leaves reduces blood sugar and increases haematological and reproductive indices in male rats. Afr J Biotechnol 2008; 7: 2299-2303.
19. Akintayo T. Chemical composition and physicochemical properties of fluted pumpkin (Telfairia occidentalis] seed and seed oils. CODEN RISGAD 1997; 74: 13-15.
20. Lee K, Dabrowski K. Long-term effects and interactions of dietary vitamins C and E on growth and reproduction of yellow perch, Perca flavescens. Aquaculture 2004; 230: 377-389. [DOI:10.1016/S0044-8486(03)00421-6]
21. Qin D, She B, She1Y, Wang J. Effects of flavonoids from Semen Cuscutae on the reproductive system in male rats. Asian J Androl 2000; 2: 99-102.
22. Das S, Parveen S, Kundra CP and Pereira BMJ. Reproduction in Male Rats is Vulnerable to Treatment with the Flavonoid-rich Seed Extracts of Vitex negundo. Phytother Res 2004; 18: 8-13. [DOI:10.1002/ptr.1352]
23. Tindall HD. Commercial Vegetable Growing. 1st Ed. Oxford University Press, Oxford, UK; 1968.
24. Akang E, Oremosu A, Dosumu O, Ejiwunmi A. Telfairia Occidentalis, a Prophylactic Medicine for Alcohol's Damaging Effect on the Testis. Macedonian J Med Sci 2011; 4: 380-387. [DOI:10.3889/MJMS.1857-5773.2011.0198]
25. Agatemor C. Studies of selected phytochemical properties of flute dpumpkin (Telferia occidentalis hook F.) seed oil and tropical Almond (Terminalis catappia I) seed oil. Pak J Nutr 2006; 5: 306-307. [DOI:10.3923/pjn.2006.306.307]
26. Azu OO, Duru FIO, Osinubi AA, Noronha CC, Elesha SO, Okanlawon AO. Preliminary study on the antioxidant effect of Kigelia africana fruit extract (Bignoniacieae) in male Sprague-Dawley rats. Afr J Biotech 2010a; 9: 1374-1381. [DOI:10.5897/AJB10.933]
27. Yan J, Agresti M, Bruce T, Yan Y, Granlund A, Matloub H. Effects of cellular phone emissions on sperm motility in rats. Fertil Steril 2007; 88: 957-964. [DOI:10.1016/j.fertnstert.2006.12.022]
28. Keel BA, Webster BW. CRC Handbook of the Laboratory Diagnosis and Treatment of Infertility. CRC Press, Boston;1990: 45-47.
29. Akang EN, Oremosu AA, Dosumu OO, Noronha CC, Okanlawon AO. The effect of fluted pumpkin (Telferia occidentalis) seed oil (FPSO) on testis and semen parameters. Agr Biol J North Am 2010; 1: 697-703.
30. Amanvermez R, Serif D, Ozgur K, Tuncel Muhlise A, Agar E. Alcohol-induced oxidative stress and reduction in oxidation by ascorbate /I-cys/I-met in the testis, ovary, kidney and lung of rat. Adv Ther 2005; 22: 548-558. [DOI:10.1007/BF02849949]
31. Egbunike GN, Branscheid W, Pfisterer J, Holtz W. Changes in porcine sperm lactate dehydrogenase isoenzymes during sperm maturation. Andrologia 1986; 18: 108-113. [DOI:10.1111/j.1439-0272.1986.tb01748.x]
32. Morales ME, Rico G, Bravo C, Tapia R, Alvarez C, Méndez JD. Progressive motility increase caused by L-arginine and polyamines in sperm from patients with idiopathic and diabetic asthenozoospermia. Ginecol Obstet Mex 2003; 71: 297-303.
33. Dawson EB, Harris WA, Teter MC, PowellLC. Effects of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992; 58: 1034-1039. [DOI:10.1016/S0015-0282(16)55456-9]
34. Fasuyi AO. Nutritional potentials of some tropical vegetable leaf meals: Chemical characterization and functional properties. Afr J Biotechnol 2006; 5: 49-53.
35. Maneesh M, Jayalekshmi H, Sanjiba Dutta, Amit Chakrabarti, Vasudevan DM. Experimental therapeutical intervention with ascorbic acid in ethanol induced testicular injuries in rats. Indian J Exp Biol 2005; 43: 172-176.
36. Cevik R, AH Gur, Suat Acar, Kemal Nas, AyÕ egül Jale Sarac. Hypothalamic-pituitarygonadal axis hormones and cortisol in both menstrual phases of women with chronic fatigue syndrome and effect of depressive mood on these hormones. BMC Musculoskelet Disord 2004; 5: 47-51. [DOI:10.1186/1471-2474-5-47]
37. Azu OO, Duru FIO, Osinubi AA, Oremosu AA, Noronha CC, Elesha SO, et al. Histomorphometric effects of Kigelia africana (Bignoniaceae) fruit extract on the testis following short-term treatment with cisplatin in male Sprague-Dawley rats. Mid East Fertil Soc J 2010b; 15: 200-208. [DOI:10.1016/j.mefs.2010.07.001]
38. Gagnon C, Iwaaski AO, de Lamirande E, Kovaski N. Reactive oxygen species and human spermatozoa. Ann N X Acad Sci 1991; 637: 436-444. [DOI:10.1111/j.1749-6632.1991.tb27328.x]
39. Mari M, Wu D, Nieto N, Cederbaum AJI. CYP2E1- Dependent Toxicity and Up-Regulation of Antioxidant Genes. J Biomed Sci 2001; 8: 52. [DOI:10.1007/BF02255971]
40. Tremellen K. Oxidative stress and male infertility- a clinical perspective. Hum Reprod Update 2008; 14: 243-258. [DOI:10.1093/humupd/dmn004]
41. Lovejoy JC. The influence of dietary fats in insulin resistance. Cur Diabetes Reports 2002; 2: 435-440. [DOI:10.1007/s11892-002-0098-y]
42. Bourre J, Dumont O, Durand G. Dose-effect of dietary oleic acid: Oleic acid is conditionally essential for some organs. Reprod Nutr Dev 2004; 44: 371-380. [DOI:10.1051/rnd:2004042]
43. Patil RB, Vora SR, Pillai MM. Antioxidant effect of plant extracts on phospholipids levels in oxidatively stressed male reproductive organs in mice. Iran J Reprod Med 2009; 7: 35-39.
44. Friedler G, Cicero TJ. Paternal pregestational opiate exposure in male mice: neuroendocrine deficits in their offspring Res. Commun Subst Abuse 1987; 8: 109.
45. Donnelly GP, McClure N, Kennedy MS, Lewis SE. Direct effect of alcohol on the motility and morphology of human spermatozoa. Andrologia 1999; 31: 43-47. [DOI:10.1111/j.1439-0272.1999.tb02841.x]
46. Martinez FE, Martinez M, Cagnon VHA, Mello Junior W, Padovani CR, Garcia PJ. Effects Of experimental chronic alcoholism on the seminal vesicle and testis weight of adult rats (Rattus norvegicus). Rev Chil Anat 1997; 15: 121-126. [DOI:10.4067/S0716-98681997000200003]
47. Van-Thiel DH, Gavaler JS, Sangavi A. Recovery of sexual function in abstinent alcoholic men. Gastroenterology 1982; 84: 677-82.
48. Anderson RA, Willis BR, Oswald C. Partial reversal of ethanol-induce male reproductive pathology following abstinence. Alc Alc 1985; 20: 273-286.
بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به International Journal of Reproductive BioMedicine می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb