Volume 12, Issue 1 (2-2014)                   IJRM 2014, 12(1): 1-6 | Back to browse issues page

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Zarei A, Parsanezhad M E, Younesi M, Alborzi S, Zolghadri J, Samsami A, et al . Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial. IJRM 2014; 12 (1) :1-6
URL: http://ijrm.ir/article-1-475-en.html
Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial
Afsoon Zarei1 , Mohammad Ebrahim Parsanezhad2 , Masoumeh Younesi * 3, Saeed Alborzi1 , Jaleh Zolghadri1 , Alamtaj Samsami1 , Sedigheh Amooee1 , Shahintaj Aramesh1
1- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
3- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran , younesi.dr@gmail.com
Abstract:   (7036 Views)
Background: The direct effect of hCG on the human endometrium was studied several times.
Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET).
Materials and Methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250μg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups.
Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively. Conclusion: Intrauterine injection of 250μg of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles
Keywords: Recombinant human chorionic gonadotropin (rhCG), Intracytoplasmic sperm injection (ICSI), In vitro fertilization (IVF), Implantation rate, Pregnancy rate.
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Type of Study: Original Article |
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