Volume 12, Issue 6 (8-2014)                   IJRM 2014, 12(6): 409-0 | Back to browse issues page

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Shen C, Shu D, Zhao X, Gao Y. Comparison of clinical outcomes between fresh embryo transfers and frozen-thawed embryo transfers. IJRM 2014; 12 (6) :409-0
URL: http://ijrm.ir/article-1-552-en.html
Comparison of clinical outcomes between fresh embryo transfers and frozen-thawed embryo transfers
Chunjuan Shen1 , Defeng Shu2 , Xiaojie Zhao2 , Ying Gao * 3
1- Department of Obstetrics and Gynecology, :union: Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022,
2- Department of Obstetrics and Gynecology, :union: Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, China
3- Department of Obstetrics and Gynecology, :union: Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, China , gying13@163.com
Abstract:   (2870 Views)
Background: Advances in embryo culture technology and cryopreservation have led to a shift in in vitro fertilization (IVF) from early fresh or frozen-thawed cleavage embryo transfer to fresh or frozen-thawed blastocyst stage transfer.
Objective: To compare the clinical outcomes of fresh embryo transfers and frozen-thawed embryo transfers.
Materials and Methods: In this retrospective case control study, patients undergoing IVF cycles from January 2012 to December 2012 were enrolled in Assisted Reproduction of Wuhan :union: Hospital were enrolled. A total of 1891 cycle contains 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers were studied. All data were transferred directly to SPSS 18 and analyzed.
Results: Clinical pregnancy rates of fresh cleavage-stage embryo transfers compared with fresh blastocyst transfers, frozen-thawed cleavage-stage embryo transfers, post thaw cleavage-stage extended blastocyst culture transfers and frozen-thawed blastocyst transfers were 52.7%, 35.88%, 35.29%, 47.75%, 59.8% in patients under 35 years of ages and 41.24%, 26.92%, 11.32%, 46.15%, 55.8% in patients older than 35 years old, respectively. The multiple pregnancy rates, abortion rates and ectopic pregnancy rates did not differ significantly among the five groups.
Conclusion: The clinical pregnancy rates were not different significantly between fresh cleavage-stage embryo transfers and fresh blastocyst transfers. But the clinical pregnancy rate of frozen-thawed blastocyst transfer was the highest among fresh/frozen-thawed embryo transfers.
Keywords: In vitro fertilization, Embryo transfer, Clinical outcome, Ectopic pregnancy, Endometrial receptivity.
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Type of Study: Original Article |
References
1. Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature 1983; 305: 707-709. [DOI:10.1038/305707a0]
2. Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis CA, Fatemi H, Tarlatzis B, et al. Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod 2008; 23: 91-99. [DOI:10.1093/humrep/dem339]
3. Aflatoonian A, Oskouian H, Ahmadi S, Oskouian L. Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial. J Assist Reprod Genet 2010; 27: 357-363. [DOI:10.1007/s10815-010-9412-9]
4. Zhou F, Lin XN, Tong XM, Li C, Liu L, Jin XY, et al. A frozen-thawed embryo transfer program improves the embryo utilization rate. Chinese Med J 2009; 122: 1974-1978.
5. Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 2000; 73: 1155-1158. [DOI:10.1016/S0015-0282(00)00518-5]
6. Roque M, Lattes K, Serra S, Sola I, Geber S, Carreras R, et al. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril 2013; 99: 156-162. [DOI:10.1016/j.fertnstert.2012.09.003]
7. Mesut N, Ciray HN, Mesut A, Aksoy T, Bahceci M. Cryopreservation of blastocysts is the most feasible strategy in good responder patients. Fertil Steril 2011; 96: 1121-1125. [DOI:10.1016/j.fertnstert.2011.08.012]
8. Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev (Online) 2012; 7: CD002118. [DOI:10.1002/14651858.CD002118.pub4]
9. Yu Ng EH, Yeung WS, Yee Lan Lau E, So WW, Ho PC. High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles. Hum Reprod 2000; 15: 250-255. [DOI:10.1093/humrep/15.2.250]
10. Basir GS, O WS, Ng EH, Ho PC. Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation. Hum Reprod 2001; 16: 435-440. [DOI:10.1093/humrep/16.3.435]
11. Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metabol 2004; 15: 84-90. [DOI:10.1016/j.tem.2004.01.009]
12. Horcajadas JA, Riesewijk A, Polman J, van Os R, Pellicer A, Mosselman S, et al. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod 2005; 11: 195-205. [DOI:10.1093/molehr/gah150]
13. Liu HJ, Chunhui ZhG, Zubing Sh. Impact of total gonadotropin dose on oocyte morphology and clinical outcome in ovarian stimulation cycles. Prog Obstet Gynecol 2006; 15: 295-298.
14. Mangalraj AM, Muthukumar K, Aleyamma T, Kamath MS, George K. Blastocyst stage transfer vs cleavage stage embryo transfer. J Hum Reprod Sci 2009; 2: 23-26. [DOI:10.4103/0974-1208.51339]
15. Tong GQ, Cao SR, Wu X, Zhang JQ, Cui J, Heng BC, et al. Clinical outcome of fresh and vitrified-warmed blastocyst and cleavage-stage embryo transfers in ethnic Chinese ART patients. J Ovarian Res 2012; 5: 27. [DOI:10.1186/1757-2215-5-27]
16. Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C. Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy. Fertil Steril 2012; 98: 1490-1494. [DOI:10.1016/j.fertnstert.2012.07.1136]
17. Aytoz A, Van den Abbeel E, Bonduelle M, Camus M, Joris H, Van Steirteghem A, et al. Obstetric outcome of pregnancies after the transfer of cryopreserved and fresh embryos obtained by conventional in-vitro fertilization and intracytoplasmic sperm injection. Hum Reprod 1999; 14: 2619-2624. [DOI:10.1093/humrep/14.10.2619]
18. Aflatoonian A, Mansoori Moghaddam F, Mashayekhy M, Mohamadian F. Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles. J Assist Reprod Genet 2010; 27: 695-700. [DOI:10.1007/s10815-010-9470-z]
19. Shih W, Rushford DD, Bourne H, Garrett C, McBain JC, Healy DL, et al. Factors affecting low birthweight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection. Hum Reprod 2008; 23: 1644-1653. [DOI:10.1093/humrep/den150]
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