Volume 12, Issue 8 (8-2014)                   IJRM 2014, 12(8): 555-0 | Back to browse issues page

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Zheng B, Xue X, Zhao Y, Chen J, Yi Xu C, Duan P. The differential expression of microRNA-143,145 in endometriosis. IJRM 2014; 12 (8) :555-0
URL: http://ijrm.ir/article-1-573-en.html
The differential expression of microRNA-143,145 in endometriosis
Bingbing Zheng1 , Xiangyang Xue2 , Yiping Zhao3 , Jing Chen4 , Chao Yi Xu5 , Ping Duan * 6
1- Department of Obstetrics, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China
2- Department of Microbiology, Wenzhou Medical University, Zhejiang, China
3- Department of Gynecology, Zhuji People's Hospital, Zhejiang, China
4- Department of Reproductive Medicine, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China
5- Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China
6- Department of Obstetrics, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China , duanping_2011@163.com
Abstract:   (2491 Views)
Background: Recent studies showed that inappropriate expression of microRNAs (miRNAs) is strongly associated with tumor-related processes in humans (2-9,11-17).
Objective: To understand the changes of miRNAs in endometriosis.
Materials and Methods: With real-time RT-PCR, we investigated the miR-143 and miR-145 expression in eutopic (EU, n=2) and ectopic endometrium (EC, n=11) (from women with endometriosis) (as well as EU+EC, n=11), along with the normal endometrium (EN, n=22) (from women without endometriosis, but with leiomyoma).
Results: We did not find that the expression of miR-143 and/or miR-145 in EN or EC changed with menstrual cycle. But our results showed the miR-143 was up-regulated in EC (p=0.000) compared to EN. The miR-143 was also up-regulated in EU, but the difference did not reach statistically significance (p=0.053). Compared to EU, the expression of miR-143 in EC was up-regulated (p=0.016). MiR-145 had the similar characteristic to miR-143. The miR-145 was up-regulated in both EU (p=0.004) and EC (p=0.000) in compared to EN group. When compared with EU, the miR-145 in EC was up-regulated (p=0.008).
Conclusion: In conclusion, the miR-143 and miR-145 may play a certain role in the development and progression of endometriosis.
Keywords: MiRNA (microRNA), MiR-143, MiR-145, Endometriosis
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Type of Study: Original Article |
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