Volume 13, Issue 3 (3-2015)                   IJRM 2015, 13(3): 155-160 | Back to browse issues page

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Esmaeilzadeh S, Mirabi P, Basirat Z, Zeinalzadeh M, Khafri S. Association between endometriosis and hyperprolactinemia in infertile women. IJRM 2015; 13 (3) :155-160
URL: http://ijrm.ir/article-1-629-en.html
Association between endometriosis and hyperprolactinemia in infertile women
Seddigheh Esmaeilzadeh1 , Parvaneh Mirabi * 2, Zahra Basirat1 , Mahtab Zeinalzadeh1 , Soraya Khafri3
1- Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
2- Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran , parvaneh_mirabi@yahoo.com
3- Department of Biostatistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Abstract:   (3255 Views)
Background: The association of endometriosis with hyperprolactinemia is controversial.
Objective: The present study aimed to determine the frequency of endometriosis and association of prolactin with endometriosis in infertile women.
Materials and Methods: 256 infertile women who underwent diagnostic laparoscopy for the evaluation of infertility, referred to Fatemezahra Infertility and Reproductive Health Research Center were included in a cross-sectional study. The presence of endometriosis was evaluated. To investigate the association of endometriosis with hyperprolactinemia, the patients whose infertility was not caused by endometriosis were included as control group. Serum prolactin (PRL) level was measured in both groups. The comparison of basal serum PRL levels between the two groups was performed, using independent t-test. One way ANOVA was used to determine PRL association with endometriosis stages.
Results: The frequency of endometriosis was found to be 29%. PRL levels were significantly higher in endometriosis group compared to control group (23.02±1.25 vs. 17.22±1.22 respectively, p=0.004). Statistically significant associations were found between staging of endometriosis and prolactin levels (p=0.01).
Conclusion: Hyperprolactinemia may be associated with endometriosis and its progression.
Keywords: Endometriosis, Infertility, Hyperprolactinemia, Laparoscopy
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Type of Study: Original Article |
References
1. Schrager S, Falleroni J, Edgoose J. Evaluation and treatment of endometriosis. Am Fam Physician 2013; 87: 107-113.
2. Moawad NS, Caplin A. Diagnosis, management, and long-term outcomes of rectovaginal endometriosis. Int J Womens Health 2013; 5: 753-763. [DOI:10.2147/IJWH.S37846]
3. Ilangavan K, Kalu E. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril 2010; 93: e10. [DOI:10.1016/j.fertnstert.2009.11.027]
4. Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol 2004; 160: 784-796. [DOI:10.1093/aje/kwh275]
5. Lima AP, Moura MD, Rosa e Silva AA. Prolactin and cortisol levels in women with endometriosis. Braz J Med Biol Res 2006; 39: 6. [DOI:10.1590/S0100-879X2006000800015]
6. Speroff L. clinical gynecology endocrinology and infertility. 8th Ed. Philadelphia: Lippincott Williams & Wilkins; 2011.
7. Han Y, Zou SE, Long QQ, Zhang SF. The incidence and characteristics of uterine bleeding during postoperative GnRH agonist treatment combined with estrogen-progestogen add-back therapy in endometriosis patients of reproductive age. Int J Clin Exp Med 2013; 6: 583-588.
8. Pacchiarotti A, Frati P, Milazzo GN, Catalano A, Gentile V, Moscarini M. Evaluation of serum anti-Mullerian hormone levels to assess the ovarian reserve in women with severe endometriosis. Eur J Obstet Gynecol Reprod Biol 2014; 172: 62-64. [DOI:10.1016/j.ejogrb.2013.10.003]
9. Bokor A, Koszorus E, Brodszky V, Simoens S, Rigo J. [The impact of endometriosis on the quality of life in Hungary]. Orv Hetil 2013; 154: 1426-1434. (In hungrian) [DOI:10.1556/OH.2013.29699]
10. Dong X, Liao X, Wang R, Zhang H. The impact of endometriosis on IVF/ICSI outcomes. Int J Clin Exp Pathol 2013; 6: 1911-1918.
11. Chrousos GP. Organization and integration of the endocrine system. Sleep Med Clin 2007; 2: 125-145. [DOI:10.1016/j.jsmc.2007.04.004]
12. Arumugam K. Serum prolactin levels in infertile patients with endometriosis. Malays J Pathol 1991; 13: 43-45.
13. Wang H, Gorpudolo N, Behr B. The role of prolactin- and endometriosis-associated infertility. Obstet Gynecol Surv 2009; 64: 542-547. [DOI:10.1097/OGX.0b013e3181ab5479]
14. Machida T, Taga M, Minaguchi H. Prolactin secretion in endometriotic patients. Eur J Obstet Gynecol Reprod Biol 1997; 72: 89-92. [DOI:10.1016/S0301-2115(96)02649-8]
15. Gregoriou G, Bakas P, Vitoratos N, Papadias K, Goumas K, Chryssicopoulos A, et al. Evaluation of serum prolactin levels in patients with endometriosis and infertility. Gynecol Obstet Invest 1999; 48: 48- 51. [DOI:10.1159/000010133]
16. Muse K WE, Jawal MJ. Prolactin hyperstimulation in response to thyrotropin-releasing hormone in patients with endometriosis. Fertil Steril 2000; 38: 419-422. [DOI:10.1016/S0015-0282(16)46574-X]
17. Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 273-288. [DOI:10.1210/jc.2010-1692]
18. MAFaL S. clinical gynecology endocrinology and infertility. 8th Ed. Philadelphia: Lippincott Williams & Wilkins; 2011.
19. Pauwels A, Schepens PJ, D'Hooghe T, Delbeke L, Dhont M, Brouwer A, et al. The risk of endometriosis and exposure to dioxins and polychlorinated biphenyls: a case-control study of infertile women. Hum Reprod 2001; 16: 2050-2055. [DOI:10.1093/humrep/16.10.2050]
20. Wang H, Gorpudolo N, Behr B. The Role of Prolactin and Endometriosis Associated Infertility. Obstet Gynecol Surv 2009; 54: 5452-5547. [DOI:10.1097/OGX.0b013e3181ab5479]
21. Matalliotakis I PD, Vlassis G, Vavilis D, Neonaki M, Koumantakis E. PRL, TSH and their response to the TRH test in patients with endometriosis before, during, and after treatment with danazol. GynecolObstet Invest 2000; 42: 183-186. [DOI:10.1159/000291947]
22. Matorras RRF, PØrez C, Pijoan JI, Neyro JL, Rodríguez Es- cudero FJ. Infertile woman with and without endometriosis: a case control study of luteal phase and other infertility conditions. Acta Obstet Gynecol Scand 2000; 75: 826-831. [DOI:10.3109/00016349609054711]
23. Haney AF, Handwerger S, Weinberg JB. Peritoneal fluid prolactin in infertile women with endometriosis: lack of evidence of secretory activity by endometrial implants. Fertil Steril 1984; 42: 935-938. [DOI:10.1016/S0015-0282(16)48271-3]
24. Hao M, Shi Y, Zhou C. [In vitro study of prolactin secretion by ectopic endometrial stromal cells]. Zhonghua Fu Chan Ke Za Zhi 2000; 35: 527-529. (In Chinese)
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