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Volume 13, Issue 4 (5-2015)
IJRM 2015, 13(4): 221-226 |
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Yıldız M, Vural M, Emin Erdal M, İzci Ay Ö, Görücü Yılmaz Ş, Fatih Karababa İ et al . Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders. IJRM 2015; 13 (4) :221-226
URL: http://ijrm.ir/article-1-636-en.html
URL: http://ijrm.ir/article-1-636-en.html
Mesut Yıldız1 
, Mehmet Vural2 , Mehmet Emin Erdal3 , Özlem İzci Ay3 , Şenay Görücü Yılmaz3 , İbrahim Fatih Karababa4 , Salih Selek * 5
, Mehmet Vural2 , Mehmet Emin Erdal3 , Özlem İzci Ay3 , Şenay Görücü Yılmaz3 , İbrahim Fatih Karababa4 , Salih Selek * 5
1- Department of Psychiatry, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
2- Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
3- Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey
4- Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey
5- Department of Psychiatry and Behavıoral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA ,drselek@yahoo.com
2- Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
3- Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey
4- Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey
5- Department of Psychiatry and Behavıoral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA ,
Abstract: (2568 Views)
Background: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.
Objective: The aim of this study was to investigate the association of Dopamine D3 receptor ( DRD3 ) polymorphism, and Cannabinoid receptor Type 1 ( CNR1 ) polymorphism with PMDD.
Materials and Methods: Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.
Results: Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.
Conclusion: These findings do not support a major role of DRD3 , and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
Objective: The aim of this study was to investigate the association of Dopamine D3 receptor ( DRD3 ) polymorphism, and Cannabinoid receptor Type 1 ( CNR1 ) polymorphism with PMDD.
Materials and Methods: Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.
Results: Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.
Conclusion: These findings do not support a major role of DRD3 , and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
Type of Study: Original Article |
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