Volume 14, Issue 11 (11-2016)                   IJRM 2016, 14(11): 709-712 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hadadian S, Fallahian M. Assessing the efficacy of vaginal hyoscine butyl bromide on cervical ripening prior to intrauterine procedures: A double-blinded clinical trial. IJRM 2016; 14 (11) :709-712
URL: http://ijrm.ir/article-1-704-en.html
Assessing the efficacy of vaginal hyoscine butyl bromide on cervical ripening prior to intrauterine procedures: A double-blinded clinical trial
Shiva Hadadian * 1, Masoumeh Fallahian2
1- Preventative Gynecology Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran , shivahadadian@yahoo.com
2- Preventative Gynecology Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran
Abstract:   (5068 Views)
Background: Unripe cervix prevents entering the endometrial cavity during intrauterine procedures. Mechanical dilatation of cervical canal might cause undesirable complications.
Objective: To investigate the substitute of mechanical intervention with chemical treatment by administering hyoscine to patients.
Materials and Methods: Sixty non-pregnant women, 20-70 years of age, with a closed cervix who were scheduled for an intrauterine procedure, were randomly divided into two groups. Group A as experimental (received two doses of hyoscine) and group B, as control group (received two doses of vitamin B6) in the vagina (8 hrs and 2 hrs before procedure) and the effect of these two drugs on dilatation and consistency of cervix were studied56T.
Results: Statistics resulted from Mann-Whitney U test (p=0.027) and χP2P(p=0.002) indicated that in premenopausal women, the priming effect of hyoscine on dilatation and consistency of uterine cervix was significant, but there were no significant benefits from giving vaginal hyoscine to menopausal women preoperatively (p=0.603).
Conclusion: Hyoscine proved a good choice for inducing cervical priming before intrauterine procedures in premenopausal women.
Keywords: Butylscopolammonium bromide, Cervical dilatation, Cervical ripening.
Full-Text [PDF 98 kb]   (1187 Downloads) |   |   Full-Text (HTML)  (471 Views)  
Type of Study: Original Article |
References
1. Mohammadian SH, Tavana A, Tavana SH, Mohammadian A, Fallahian M. Cervical priming by misoprostol before Diagnostic Dilatation and Curettage. J Reprod Infertil 2015; 16.
2. P Saxena, S Salhan, N Sarda. Role of sublingual Misoprostol for cervical ripening prior to vacuum aspiration in first trimester interruption of pregnancy. Contraception, 2003. [DOI:10.1016/S0010-7824(02)00517-6]
3. Rath W, Kuhn W, and Hilgers R. Facilitation of cervical dilatation by intracervical application of Sulprostone gel before hysteroscopy. Endoscopy 1985; 17: 191-193 [DOI:10.1055/s-2007-1018498]
4. Barcaite E, Bartusevicius A, Railaite DR, Nadisauskiene R. Vaginal Misoprostol for cervical priming before hysteroscopy in perimenopausal and postmenopausal women. Int J Gynaecol Obstet 2005; 91: 141-145. [DOI:10.1016/j.ijgo.2005.06.019]
5. Cunningham G, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. William's Obstetrics, 23rd Ed. McGraw-Hill Professional, Philadelphia; 2010: 297-306.
6. Sharifzade F, Kashanian M, Assadollahi Dabbagh Z. Effect of vaginal misoprostol on cervical priming in diagnostic Dilatation and Curettage. IJOGI 2010; 13: 25-30.
7. Briggs GG, Wan SR. Drug therapy during labor and delivery, part 2. Am J Health Sys Pharm 2006; 63: 1131-1139. [DOI:10.2146/ajhp050265.p2]
8. Brenda Timmons, Meredith Akins, and Mala Mahendroo. Cervical remodeling during pregnancy and parturition. Trends Endocrinol Metab 2010; 21: 353-361 [DOI:10.1016/j.tem.2010.01.011]
9. Gunvor Ekman-Ordeberg, Ylva Stjernhdm, Hong Wang, Denis Stygar, Lena Sahlin. Endocrine regulation of cervical ripening in humans-potential roles for gonadal steroids and insulin-like growth factor-1. Steroids 2003; 68: 837-847. [DOI:10.1016/j.steroids.2003.08.018]
10. Maria Aziz. Effect of rectal Hyoscine Butylbromide suppositories on the first stage of labor. Int J Adv Res 2014; 2: 128-135.
11. Samuels LA, Christie L, Roberts-Gittens B, Fletcher H, Frederick J. The effect of hyoscine butyl bromide on the first stage of labor in term pregnancies. BJOG 2007; 114: 1542-1546. [DOI:10.1111/j.1471-0528.2007.01497.x]
12. Aggarwal P, Zutshi V, Batra S. Role of hyoscine N Butylbromide (HBB, buscopan) as labor analgesia. Indian J Med Sci 2008; 62: 179-184. [DOI:10.4103/0019-5359.40982]
13. Iravani M, Bekhradinasab H. [Study of the effects of intravenous injection of hyoscine on parturition (labor)]. J Shahid Sadoughi Univ Med Sci Health 2006; 13: 59-64. (In Persian)
14. Sirohiwal D, Dahiya K, and De M. Efficacy of hyoscine N Butylbromide (Buscopan) suppositories as a cervical spasmolytic agent in labor. Aust N Z J Obstet Gynaecol 2005; 45: 128-129. [DOI:10.1111/j.1479-828X.2005.00359.x]
15. Obama M, Usui R, and Mitani Y. Clinical use of Hyoscine N Butylbromide (Buscopan). Obstet and Gynecol. 1: 3: 151-160: (March/ Quoted by Hector et al.). Estrogen pretreated cervix in postmenopausal women. Tohoku J Exp Med 2005; 206: 237-241. [DOI:10.1620/tjem.206.237]
16. Fallah, R, Karbasi, SA, Mirowliai, M and Sekhavat, L. Effect of hyoscine butylbromide on first stage of labour in multiparus women. Makerere University Medical School, 2013.
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb