شنبه 1 اردیبهشت 1403
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دوره 5، شماره 3 - ( 4-1386 )
جلد 5 شماره 3 صفحات 0-41 |
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Nayernia K, Lee J H, Engel W, Nolte J, Drusenheimer N, Rathsack K, et al et al . From stem cells to germ cells and from germ cells to stem cells. IJRM 2007; 5 (3) :41-0
URL: http://ijrm.ir/article-1-74-fa.html
URL: http://ijrm.ir/article-1-74-fa.html
From stem cells to germ cells and from germ cells to stem cells. International Journal of Reproductive BioMedicine. 1386; 5 (3) :41-0
چکیده: (3291 مشاهده)
Germline and somatic stem cells are distinct types of stem cells that are dedicated to reproduction and somatic tissue regeneration, respectively. Germline stem cells (GSCs), which can self-renew and generate gametes, are unique stem cells in that they are solely dedicated to transmit genetic information from generation to generation. We developed a strategy for the establishment of germline stem cell lines from embryonic stem cells (ES). These cells are able to undergo meiosis, generate haploid male gametes in vitro and are functional, as shown by fertilization after intra-cytoplasmic injection into mouse oocytes. In other approach, we show that bone marrow stem (BMS) cells are able to trans-differentiate into male germ cells. BMS cell-derived germ cells expressed the known molecular markers of primordial germ cells. The ability to derive male germ cells from ES and BMS cells reveals novel aspects of germ cell development and opens the possibilities for use of these cells in reproductive medicine. Conversely, we showed that adult male germline stem cells, spermatogonial stem cells (SSCs), can be converted into embryonic stem cell like cells which can differentiate into the somatic stem cells of three germ layers. Understanding how SSC can give rise to pluripotent stem cells and how somatic stem cells differentiate into germ cells could give significant insights into the regulation of developmental totipotency as well as having important implications for male fertility and regenerative medicine.
نوع مطالعه: Original Article |
فهرست منابع
1. Nayernia K, Nieter S, Kremling H, Oberwinkler H, Engel W. Functional and molecular characterization of the transcriptional regulatory region of the proacrosin gene. J Biol Chem 1994; 269: 32181-32186.
2. Nayernia K, von Mering MH, Kraszucka K, Burfeind P, Wehrend A, Kohler M, et al. A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-Sertoli cell interaction. Biol Reprod 1999; 60: 1488-1495. [DOI:10.1095/biolreprod60.6.1488]
3. Nayernia K, Vauti F, Meinhardt A, Cadenas C, Schweyer S, Meyer BI, et al. Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility. J Biol Chem 2003; 278: 48377-48385. [DOI:10.1074/jbc.M309583200]
4. Nayernia K, Drabent B, Adham IM, Moschner M, Wolf S, Meinhardt A, et al. Male mice lacking three germ cell expressed genes are fertile. Biol Reprod 2003; 69: 1973-1978. [DOI:10.1095/biolreprod.103.018564]
5. Nayernia K., Adham I., Kremling H., Reim H., Schliker M., Schlüter G., et al. Stage and developmental specific gene expression during mammalian spermatogenesis. Int J Dev Biol 1996; 40: 379-383.
6. Nayernia K, Li Manyu, Engel W. Spermatogonial stem cells in germ cell protocols. Humana Press 2003; 253:105-120. [DOI:10.1385/1-59259-744-0:105]
7. Tascou S, Nayernia K, Samani A, Schmidtke J, Vogel T, Engel W, et al. Immortalization of murine male germ cells at a discrete stage of differentiation by a novel directed promoter-based selection strategy. Biol Reprod 2000; 63: 1555-1561. [DOI:10.1095/biolreprod63.5.1555]
8. Nayernia K, Engel W. Molecular and cellular approaches for establishment of an in vitro spermatogenesis system in Germ Cell Protocols. Humana Press 2003; 253:121-133. [DOI:10.1385/1-59259-744-0:121]
9. Nayernia K, Nolte J, Michelmann, Lee JH, Rathsack K, Drusenheimer N, et al. In vitro differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. Dev Cell 2006; 11:125-132. [DOI:10.1016/j.devcel.2006.05.010]
10. Lee JH, Schütte D, Wulf D , Füzesi L, Radzun HJ, Schweyer S, et al. Stem cell protein piwil2 is widely expressed in tumors and inhibits apoptosis through activation of stat3/Bcl-XL pathway. Mol Hum Genet 2006; 15:201-211. [DOI:10.1093/hmg/ddi430]
11. Kuramochi-Miyagawa S, Kimura T, Yomogida K, Kuroiwa A, Tadokoro Y, Fujita Y, et al. Two mouse piwi-related genes: miwi and mili. Mech Dev 2001; 108:121-133. [DOI:10.1016/S0925-4773(01)00499-3]
12. Lee JH, Engel W, Nayernia K. Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes. Mol Reprod Dev 2006; 73:173-179. [DOI:10.1002/mrd.20391]
13. Cerutti L, Mian N, Bateman A. Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. Trends Biochem Sci 2000; 25:481-482. [DOI:10.1016/S0968-0004(00)01641-8]
14. Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, et al. Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 2004; 131:839-849. [DOI:10.1242/dev.00973]
15. Aravin A, Gaidatzis D, Pfeffer S, Lagos-Quintana M, Landgraf P, Iovino N, et al. A novel class of small RNAs bind to MILI protein in mouse testes. Nature 2006; 442:203-7. [DOI:10.1038/nature04916]
16. Boiani M, Scholer HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005; 6:872-84. [DOI:10.1038/nrm1744]
17. Jaronczyk K, Carmichael JB, Hobman TC. Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? Biochem J 2005; 387:561-571. [DOI:10.1042/BJ20041822]
18. Guan K, Nayernia K, Maier LS, Wagner S, Dressel R, Lee JH, et al. Pluripotency of spermatogonial stem cells from adult mouse testis. Nature 2006;440:1199-1203. [DOI:10.1038/nature04697]
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