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Reproductive Biomedicine
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Volume 14, Issue 7 (7-2016)
IJRM 2016, 14(7): 465-470 |
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Arefi S, Hoseini A, Farifteh F, Zeraati H. Modified natural cycle frozen-thawed embryo transfer in patients with repeated implantation failure: An observational study. IJRM 2016; 14 (7) :465-470
URL: http://ijrm.ir/article-1-767-en.html
URL: http://ijrm.ir/article-1-767-en.html
1- Avicenna Research Institute, Shahid Beheshti University, Tehran, Iran , soheilaarefi@yahoo.com
2- GIVAR (Genetic & In Vitro Assisted Reproduction) Center, Erfan hospital, Tehran, Iran
3- Avicenna Research Institute, Shahid Beheshti University, Tehran, Iran
2- GIVAR (Genetic & In Vitro Assisted Reproduction) Center, Erfan hospital, Tehran, Iran
3- Avicenna Research Institute, Shahid Beheshti University, Tehran, Iran
Abstract: (5641 Views)
Background: Natural endometrium in Frozen-thawed Embryo Transfer (FET) may have some benefits upon implantation in patients with Repeated Implantation Failure (RIF). It might be due to possible differences between natural and stimulated endometrial growth factors and cytokins secretions.
Objective: The objective of this study was to compare the pregnancy rate of FET on modified natural cycle versus hormone replacement therapy (HRT) cycle endometrium in patients with RIF.
Materials and Methods: In this observational study the pregnancy rate of patients with RIF undergoing day 3 FET in natural cycle endometrium (group 1, n=56), were compared with another group of patients with RIF in whom frozen-thawed day 3 embryos were transferred on HRT cycle (group 2, n=52).
Results: The pregnancy rate in group 1 was 41.07%, compared with the pregnancy rate of group 2; 36.5% (p=0.63). The abortion rate was not significantly different among the groups.
Conclusion: It can be concluded that FET in a modified natural cycle is comparable with HRT cycle in patients with RIF.
Objective: The objective of this study was to compare the pregnancy rate of FET on modified natural cycle versus hormone replacement therapy (HRT) cycle endometrium in patients with RIF.
Materials and Methods: In this observational study the pregnancy rate of patients with RIF undergoing day 3 FET in natural cycle endometrium (group 1, n=56), were compared with another group of patients with RIF in whom frozen-thawed day 3 embryos were transferred on HRT cycle (group 2, n=52).
Results: The pregnancy rate in group 1 was 41.07%, compared with the pregnancy rate of group 2; 36.5% (p=0.63). The abortion rate was not significantly different among the groups.
Conclusion: It can be concluded that FET in a modified natural cycle is comparable with HRT cycle in patients with RIF.
Type of Study: Original Article |
References
1. Rubio C, Gil-Salom M, Simón C, Vidal F, Rodrigo L, Mínguez Y, et al. Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome. Hum Reprod 2001; 16: 2084-2092. [DOI:10.1093/humrep/16.10.2084]
2. Raziel A, Friedler S, Schachter M, Kasterstein E, Strassburger D, Ron-El R. Increased frequency of female partner chromosomal abnormalities in patients with high-order implantation failure after in vitro fertilization. Fertil Steril 2002; 78: 515-551. [DOI:10.1016/S0015-0282(02)03298-3]
3. Harper JC, Coonen E, Handyside AH, Winston RML, Hopman AHN, Delhanty JDA. Mosaicism of autosomes and sex chromosomes in morphologically normal, monospermic pre-implantation human embryos. Prenat Diag 1995; 15: 41-49. [DOI:10.1002/pd.1970150109]
4. Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, et al. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod 2006; 21: 2694-2698. [DOI:10.1093/humrep/del203]
5. Coulam CB, Jeyemdran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online 2006; 12: 322-327. [DOI:10.1016/S1472-6483(10)61004-8]
6. Miko E, Manfai Z, Meggyes M, Barakonyi A, Wilhelm F, Varnagy A, et al. Possible role of natural killer and natural killer T-like cells in implantation failure after IVF. Reprod Biomed Online 2010; 21: 750-756. [DOI:10.1016/j.rbmo.2010.07.012]
7. Mariee N, Li TC, Laird SM. Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells. Hum Reprod 2012; 27: 71946-71954. [DOI:10.1093/humrep/des134]
8. Ledee-Bataille N, Bonnet-Chea K, Hosny G, Dubanchet S, Frydman R, Chaouat G. Role of the endometrial tripod interleukin-18-15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure. Fertil Steril 2005; 83: 598-605. [DOI:10.1016/j.fertnstert.2004.11.021]
9. Inagaki N, Stern C, McBain J, Lopata A, Kornman L, Wilkinson D. Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer. Hum Reprod 2003; 18: 608-615. [DOI:10.1093/humrep/deg139]
10. Arefi S, Soltanghoraei H, Sadeghi MR, Tabaei AS, Zeraati H, Zarnani H, Findings on hysteroscopy in patients with in vitro fertilization by intra cytoplasmic single sperm injection and embryo transfer failures. Saudi Med J 2008; 29: 1201-1202.
11. Lédée-Bataille N,Olivennes F, Lefaix JL, Chaouat G, Frydman R, Delanian S. Combined treatment by pentoxifilline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation program. Hum Reprod 2002; 17: 1249-1253. [DOI:10.1093/humrep/17.5.1249]
12. Zinger M, Liu JH, Thomas MA. Successful use of vaginal sildenafil citrate in two infertility patients with Asherman's syndrome. J Women's Health (Larchmt) 2006; 15: 442-444. [DOI:10.1089/jwh.2006.15.442]
13. Boomsma CM, Kavelaars A, Eijkemans MJ, Fauser BC, Heijnen CJ, Macklon NS. Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo. Fertil Steril 2010; 94: 1764-1768. [DOI:10.1016/j.fertnstert.2009.10.044]
14. Glujovsky D, Pesce R, Fiszbajn G, Sueldo C, Hart RJ, Ciapponi A. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev 2010; 1: CD006359. [DOI:10.1002/14651858.CD006359.pub2]
15. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril 2011; 96: 344-348. [DOI:10.1016/j.fertnstert.2011.05.050]
16. Shapiro BS, Daneshmand ST, Restrepo H, Garner FC, Aguirre M, Hudson C. Matched-cohort comparison of single-embryo transfers in fresh and frozen-thawed embryo transfer cycles. Fertil Steril 2013; 99: 389-392. [DOI:10.1016/j.fertnstert.2012.09.044]
17. Groenewoud ER, Macklon NS, Cohlen BJ. Antarctica trial study group.Cryo-thawed embryo transfer: natural versus artificial cycle. A non-I nferiority trial. (ANTARCTICA trial). BMC Womens Health 2012; 12: 27. [DOI:10.1186/1472-6874-12-27]
18. Xiao Z, Zhou X, Xu W, Yang J, Xie Q. Natural cycle is superior to hormone replacement therapy cycle for vitrificated-preserved frozen-thawed embryo transfer. Syst Biol Reprod Med 2012; 58: 107-112. [DOI:10.3109/19396368.2011.646047]
19. Queenan JT Jr, Veeck LL, Seltman HJ, Muasher SJ. Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results. Fertil Steril 1994; 62: 545-550. [DOI:10.1016/S0015-0282(16)56943-X]
20. Chang EM, Han JE, Kim YS, Lyu SW, Lee WS, Yoon TK. Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes: cycle regimens of vitrification thawed blastocyst transfer. J Assist Reprod Genet 2011; 28: 369-374. [DOI:10.1007/s10815-010-9530-4]
21. Chai J, Lee KF, Ng EH, Yeung WS, Ho PC. Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles. Fertil Steril 2011; 96: 764-768. [DOI:10.1016/j.fertnstert.2011.06.015]
22. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril 2007; 87: 53-59. [DOI:10.1016/j.fertnstert.2006.05.064]
23. Friedler S, Schenker JG, Herman A, Lewin A. The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments: a critical review. Hum Reprod Update 1996; 2: 323-335. [DOI:10.1093/humupd/2.4.323]
24. Licht P, von Wolff M, Berkholz A, Wildt L. Evidence for cycle-dependent expression of full-length human chorionic gonadotropin/luteinizing hormone receptor mRNA in human endometrium and decidua. Fertil Steril 2003; 79: 718-723. [DOI:10.1016/S0015-0282(02)04822-7]
25. Min JK, Claman P, Hughes E, Cheung AP, Claman P, Fluker M, et al. Guidelines for the number of embryos to transfer following in vitro fertilization No. 182, September. JOINT SOGC-CFAS. Int J Gynaecol Obstet 2006; 102: 203-216.
26. Lee VC, Li RH, Ng EH, Yeung WS, Ho PC. Luteal phase support does not improve the clinical pregnancy rate of natural cycle frozen-thawed embryo transfer: a retrospective analysis. Eur J Obstet Gynecol Reprod Biol 2013; 169: 50-53. [DOI:10.1016/j.ejogrb.2013.02.005]
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