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Volume 14, Issue 9 (9-2016)
IJRM 2016, 14(9): 597-602 |
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Ghadiri-Anari A, Mortezaii-Shoroki Z, Modarresi M, Dehghan A. Association of lipid profile with bone mineral density in postmenopausal women in Yazd province. IJRM 2016; 14 (9) :597-602
URL: http://ijrm.ir/article-1-781-en.html
URL: http://ijrm.ir/article-1-781-en.html
1- Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , ghadiriam@yahoo.com
2- School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Community Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Community Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (2716 Views)
Background: Low bone mass is a major health problem in postmenopausal women.There is no general agreement regarding relationship between serum level of lipidsand bone mineral density.
Objective: This study was carried out to investigate the association between lipidprofile and bone mineral density (BMD) in postmenopausal women in Yazd, Iran.
Materials and Methods: This cross-sectional study was performed on 170 womenaged between 50 and 70 years old with menopause for at least one year from Yazd,Iran, between March 2013 to September 2013. Association of lipid profile and BMDwere measured in all study participants.
Results: Among our participants 73 cases had lumbar osteoporosis, 17 cases hadfemoral osteoporosis and 80 cases did n’t have osteoporosis. After controlling forbody mass index, there were no correlations between serum level of lipids and bonemineral density of femur and lumbar bones.
Conclusion: No significant association between serum level of lipids and BMD offemur and lumbar was found in postmenopausal women
Objective: This study was carried out to investigate the association between lipidprofile and bone mineral density (BMD) in postmenopausal women in Yazd, Iran.
Materials and Methods: This cross-sectional study was performed on 170 womenaged between 50 and 70 years old with menopause for at least one year from Yazd,Iran, between March 2013 to September 2013. Association of lipid profile and BMDwere measured in all study participants.
Results: Among our participants 73 cases had lumbar osteoporosis, 17 cases hadfemoral osteoporosis and 80 cases did n’t have osteoporosis. After controlling forbody mass index, there were no correlations between serum level of lipids and bonemineral density of femur and lumbar bones.
Conclusion: No significant association between serum level of lipids and BMD offemur and lumbar was found in postmenopausal women
Type of Study: Original Article |
References
1. Orozco P. Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women. Eur J Epidemiol 2004; 19: 1105-1112. [DOI:10.1007/s10654-004-1706-8]
2. Tanko LB, Bagger YZ, Nielsen SB, Christiansen C. Does serum cholesterol contribute to vertebral bone loss in postmenopausal women? Bone 2003; 32: 8-14. [DOI:10.1016/S8756-3282(02)00918-3]
3. Uyama O, Yoshimoto Y, Yamamoto Y, Kawai A. Bone changes and carotid atherosclerosis in postmenopausal women. Stroke 1997; 28: 1730-1732. [DOI:10.1161/01.STR.28.9.1730]
4. Solomon DH, Avorn J, Canning CF, Wang PS. Lipid levels and bone mineral density. Am J Med 2005; 118: 1414. [DOI:10.1016/j.amjmed.2005.07.031]
5. Samelson EJ, Cupples LA, Hannan MT, Wilson PW, Williams SA, Vaccarino V. Long-term effects of serum cholesterol on bone mineral density in women and men: the Framingham Osteoporosis Study. Bone 2004; 34: 557-561. [DOI:10.1016/j.bone.2003.11.024]
6. Wu LY, Yang TC, Kuo SW, Hsiao CF, Hung YJ, Hsieh CH. Correlation between bone mineral density and plasma lipids in Taiwan. Endocr Res 2003; 29: 317-325. [DOI:10.1081/ERC-120025039]
7. Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR. Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 2005; 20: 1912-1920. [DOI:10.1359/JBMR.050711]
8. Baron R, Rawadi G, Roman‐Roman S. Wnt signaling: a key regulator of bone mass. Curr Top Dev Biol 2006; 76: 103-127. [DOI:10.1016/S0070-2153(06)76004-5]
9. Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 2007; 315: 1278-1282. [DOI:10.1126/science.1136370]
10. Makovey J, Macara M, Chen JS, Hayward CS, March L, Sambrook PN. High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women. Bone 2013; 52: 120-125. [DOI:10.1016/j.bone.2012.09.025]
11. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499.
12. Bauer DC. HMG CoA reductase inhibitors and the skeleton: a comprehensive review. Osteoporos Int 2003; 14: 273-282. [DOI:10.1007/s00198-002-1323-x]
13. Hernández JL, Olmos JM, Roma-a G, Martinez J, Castillo J, Yezerska I, et al. Bone mineral density in statin users: a population-based analysis from a Spanish cohort. J Bone Mineral Metab 2014; 32: 184-191. [DOI:10.1007/s00774-013-0481-6]
14. Chuengsamarn S, Rattanamongkoulgul S, Suwanwalaikorn S, Wattanasirichaigoon S, Kaufman L. Effects of statins vs. non-statin lipid-lowering therapy on bone formation and bone mineral density biomarkers in patients with hyperlipidemia. Bone 2010; 46:1011-1015. [DOI:10.1016/j.bone.2009.12.023]
15. Wada Y, Nakamura Y, Koshiyama H. Lack of positive correlation between statin use and bone mineral density in Japanese subjects with type 2 diabetes. Arch Int Med 2000; 160: 2865. [DOI:10.1001/archinte.160.18.2865]
16. Prasad G, Chiu R, Nash MM, Zaltzman JS. Statin use and bone mineral density in renal transplant recipients. Am J Transplant 2003; 3: 1320-1321.
17. Sivas F, Alemdaroğlu E, Elverici E, Kuluğ T, Özoran K. Serum lipid profile: its relationship with osteoporotic vertebrae fractures and bone mineral density in Turkish postmenopausal women. Rheumatol Int 2009; 29: 885-890. [DOI:10.1007/s00296-008-0784-4]
18. Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y, Demer LL. Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. J Bone Mineral Res 2002; 17: 1997-2003. [DOI:10.1359/jbmr.2002.17.11.1997]
19. Brownbill R, Ilich J. Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. J Women's Health 2006; 15: 261-270. [DOI:10.1089/jwh.2006.15.261]
20. Ackert-Bicknell CL. HDL cholesterol and bone mineral density: is there a genetic link? Bone 2012; 50: 525-533 [DOI:10.1016/j.bone.2011.07.002]
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